ENSMUSG00000089678


Mus musculus

Features
Gene ID: ENSMUSG00000089678
  
Biological name :Agxt2
  
Synonyms : Agxt2 / Alanine--glyoxylate aminotransferase 2, mitochondrial / Q3UEG6
  
Possible biological names infered from orthology : alanine--glyoxylate aminotransferase 2 / Q9BYV1
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: A1
Gene start: 10358532
Gene end: 10410153
  
Corresponding Affymetrix probe sets: 10423053 (MoGene1.0st)   1435838_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022858
Ensembl peptide - ENSMUSP00000106170
Ensembl peptide - ENSMUSP00000106171
NCBI entrez gene - 268782     See in Manteia.
MGI - MGI:2146052
RefSeq - XM_006520070
RefSeq - NM_001031851
RefSeq - NM_001310735
RefSeq - NM_001310736
RefSeq - XM_006520069
RefSeq Peptide - NP_001027021
RefSeq Peptide - NP_001297664
RefSeq Peptide - NP_001297665
swissprot - H7BWY3
swissprot - Q3UEG6
swissprot - D3YZ49
Ensembl - ENSMUSG00000089678
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 agxt2ENSDARG00000100709Danio rerio
 AGXT2ENSGALG00000003432Gallus gallus
 AGXT2ENSG00000113492Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Etnppl / Q8BWU8 / ethanolamine phosphate phospholyase / Q8TBG4* / ethanolamine-phosphate phospho-lyase*ENSMUSG0000001923230
Phykpl / Q8R1K4 / 5-phosphohydroxy-L-lysine phospholyase / Q8IUZ5* / 5-phosphohydroxy-L-lysine phospho-lyase*ENSMUSG0000002035926


Protein motifs (from Interpro)
Interpro ID Name
 IPR005814  Aminotransferase class-III
 IPR015421  Pyridoxal phosphate-dependent transferase, major domain
 IPR015422  Pyridoxal phosphate-dependent transferase domain 1
 IPR015424  Pyridoxal phosphate-dependent transferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009436 glyoxylate catabolic process IEA
 biological_processGO:0019265 glycine biosynthetic process, by transamination of glyoxylate IEA
 biological_processGO:0019481 L-alanine catabolic process, by transamination IEA
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IEA
 cellular_componentGO:0005739 mitochondrion IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0008453 alanine-glyoxylate transaminase activity IEA
 molecular_functionGO:0008483 transaminase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030170 pyridoxal phosphate binding IEA
 molecular_functionGO:0042802 identical protein binding IBA
 molecular_functionGO:0047305 (R)-3-amino-2-methylpropionate-pyruvate transaminase activity IEA


Pathways (from Reactome)
Pathway description
Glyoxylate metabolism and glycine degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000231 hypertension "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ndst1tm1Je/Ndst1tm1Je,Robo4tm1Kzh/Robo4tm1Kzh,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005311 abnormal circulating amino acid level "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]
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Allelic Composition: Ndst1tm1Je/Ndst1tm1Je,Robo4tm1Kzh/Robo4tm1Kzh,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005590 increased vasodilation "greater than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ndst1tm1Je/Ndst1tm1Je,Robo4tm1Kzh/Robo4tm1Kzh,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000089678 Agxt2 / Q3UEG6 / Alanine--glyoxylate aminotransferase 2, mitochondrial / Q9BYV1* / alanine--glyoxylate aminotransferase 2*  / complex






 

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