Manteia

ENSMUSG00000020359

Mus musculus

Features

Gene ID:	ENSMUSG00000020359

Biological name :	Phykpl

Synonyms :	5-phosphohydroxy-L-lysine phospholyase / Phykpl / Q8R1K4

Possible biological names infered from orthology :	5-phosphohydroxy-L-lysine phospho-lyase / Q8IUZ5

Species:	Mus musculus

Chr. number:	11
Strand:	1
Band:	B1.3
Gene start:	51584757
Gene end:	51604489

Corresponding Affymetrix probe sets:	10375864 (MoGene1.0st) 1424745_at (Mouse Genome 430 2.0 Array) 1444186_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000020625 Ensembl peptide - ENSMUSP00000098808 Ensembl peptide - ENSMUSP00000132190 NCBI entrez gene - 72947 See in Manteia. MGI - MGI:1920197 RefSeq - XM_017314796 RefSeq - NM_028398 RefSeq - XM_006534323 RefSeq - XM_006534324 RefSeq - XM_006534325 RefSeq Peptide - NP_082674 swissprot - Q8R1K4 swissprot - F8WHK6 Ensembl - ENSMUSG00000020359

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Etnppl / Q8BWU8 / ethanolamine phosphate phospholyase / Q8TBG4* / ethanolamine-phosphate phospho-lyase*	ENSMUSG00000019232	61
Agxt2 / Q3UEG6 / Alanine--glyoxylate aminotransferase 2, mitochondrial / Q9BYV1* / alanine--glyoxylate aminotransferase 2*	ENSMUSG00000089678	30

Protein motifs (from Interpro)

Interpro ID	Name
IPR005814	Aminotransferase class-III
IPR015422	Pyridoxal phosphate-dependent transferase domain 1
IPR015424	Pyridoxal phosphate-dependent transferase

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0008150	biological_process	ND
cellular_component	GO:0005739	mitochondrion	IDA
molecular_function	GO:0003824	catalytic activity	IEA
molecular_function	GO:0008453	alanine-glyoxylate transaminase activity	IBA
molecular_function	GO:0008483	transaminase activity	IEA
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0016829	lyase activity	IEA
molecular_function	GO:0030170	pyridoxal phosphate binding	IBA
molecular_function	GO:0042802	identical protein binding	IBA

Pathways (from Reactome)

Pathway description

Collagen degradation

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001325	abnormal retina morphology	"structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Otud7b^{tm1(NCOM)Cmhd}/Otud7b^{tm1(NCOM)Cmhd} Genetic Background: C57BL/6N-Otud7b^{tm1(NCOM)Cmhd}/Tcp
MP:0002966	decreased circulating alkaline phosphatase level	"reduced activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Otud7b^{tm1(NCOM)Cmhd}/Otud7b^{tm1(NCOM)Cmhd} Genetic Background: C57BL/6N-Otud7b^{tm1(NCOM)Cmhd}/Tcp
MP:0005554	decreased circulating creatinine level	"less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Otud7b^{tm1(NCOM)Cmhd}/Otud7b^{tm1(NCOM)Cmhd} Genetic Background: C57BL/6N-Otud7b^{tm1(NCOM)Cmhd}/Tcp

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000020359	Phykpl / Q8R1K4 / 5-phosphohydroxy-L-lysine phospholyase / Q8IUZ5* / 5-phosphohydroxy-L-lysine phospho-lyase*	/ complex

0 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr