ENSG00000175309


Homo sapiens

Features
Gene ID: ENSG00000175309
  
Biological name :PHYKPL
  
Synonyms : 5-phosphohydroxy-L-lysine phospho-lyase / PHYKPL / Q8IUZ5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q35.3
Gene start: 178208497
Gene end: 178232791
  
Corresponding Affymetrix probe sets: 226519_s_at (Human Genome U133 Plus 2.0 Array)   226783_at (Human Genome U133 Plus 2.0 Array)   232488_at (Human Genome U133 Plus 2.0 Array)   235669_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000423806
Ensembl peptide - ENSP00000421810
Ensembl peptide - ENSP00000424608
Ensembl peptide - ENSP00000427444
Ensembl peptide - ENSP00000425425
Ensembl peptide - ENSP00000310978
Ensembl peptide - ENSP00000321290
Ensembl peptide - ENSP00000377128
NCBI entrez gene - 85007     See in Manteia.
OMIM - 614683
RefSeq - XM_017009999
RefSeq - XM_011534669
RefSeq - XM_011534670
RefSeq - XM_011534671
RefSeq - XM_011534672
RefSeq - XM_011534674
RefSeq - XM_011534676
RefSeq - XM_017009995
RefSeq - XM_017009996
RefSeq - XM_017009997
RefSeq - XM_017009998
RefSeq - NM_001278346
RefSeq - NM_153373
RefSeq - XM_006714925
RefSeq Peptide - NP_001265275
RefSeq Peptide - NP_699204
swissprot - H0Y9N3
swissprot - H0YAK5
swissprot - H7BXR0
swissprot - D6RD89
swissprot - Q8IUZ5
swissprot - D6RAR0
swissprot - H7BYK2
swissprot - D6RCB8
Ensembl - ENSG00000175309
  
Related genetic diseases (OMIM): 615011 - [?Phosphohydroxylysinuria], 615011
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 phykplENSDARG00000040566Danio rerio
 PHYKPLENSGALG00000023920Gallus gallus
 PhykplENSMUSG00000020359Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ETNPPL / Q8TBG4 / ethanolamine-phosphate phospho-lyaseENSG0000016408964
AGXT2 / Q9BYV1 / alanine--glyoxylate aminotransferase 2ENSG0000011349231


Protein motifs (from Interpro)
Interpro ID Name
 IPR005814  Aminotransferase class-III
 IPR015421  Pyridoxal phosphate-dependent transferase, major domain
 IPR015422  Pyridoxal phosphate-dependent transferase domain 1
 IPR015424  Pyridoxal phosphate-dependent transferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006554 lysine catabolic process TAS
 biological_processGO:0030574 collagen catabolic process TAS
 cellular_componentGO:0005739 mitochondrion IBA
 cellular_componentGO:0005759 mitochondrial matrix TAS
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008453 alanine-glyoxylate transaminase activity IBA
 molecular_functionGO:0008483 transaminase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016829 lyase activity TAS
 molecular_functionGO:0030170 pyridoxal phosphate binding IEA
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
Collagen degradation
Lysine catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000175309 PHYKPL / Q8IUZ5 / 5-phosphohydroxy-L-lysine phospho-lyase  / complex






 

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