ENSMUSG00000102418


Mus musculus

Features
Gene ID: ENSMUSG00000102418
  
Biological name :Sh2d1b1
  
Synonyms : Sh2d1b1 / SH2 domain containing 1B1
  
Possible biological names infered from orthology : O14796 / SH2D1B / SH2 domain containing 1B
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H3
Gene start: 170277320
Gene end: 170286769
  
Corresponding Affymetrix probe sets: 10351477 (MoGene1.0st)   1423024_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000137069
NCBI entrez gene - 26904     See in Manteia.
MGI - MGI:1349420
RefSeq - NM_012009
RefSeq Peptide - NP_036139
swissprot - Q149T1
Ensembl - ENSMUSG00000102418
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch73-264p11.1ENSDARG00000091835Danio rerio
 SH2D1BENSGALG00000028448Gallus gallus
 O14796ENSG00000198574Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q45HK4 / Sh2d1b2 / SH2 domain-containing protein 1B2 / SH2D1B* / O14796* / SH2 domain containing 1B*ENSMUSG0000007349482
O88890 / Sh2d1a / SH2 domain-containing protein 1A / O60880* / SH2 domain containing 1A*ENSMUSG0000000569630


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR035049  EAT-2, SH2 domain
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
No match


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003080 competent NK cell cytolysis "ability of these cells to destroy or dissolve targeted cells" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Usf1tm1Svl/Usf1+,Usf2tm1Svl/Usf2+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6J

 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
Show

Allelic Composition: Csf3rtm1Link/Csf3rtm1Link
Genetic Background: B6.129X1-Csf3rtm1Link

Allelic Composition: Sh2d1b1tm1.1Cpt/Sh2d1b1tm1.1Cpt
Genetic Background: involves: BALB/cJ * C57BL/6

Allelic Composition: Sh2d1b1/Sh2d1b2tm1.1Cpt/Sh2d1b1/Sh2d1b2tm1.1Cpt
Genetic Background: involves: BALB/cJ

Allelic Composition: Sh2d1atm1Cpt/Sh2d1atm1Cpt,Sh2d1b1/Sh2d1b2tm1.1Cpt/Sh2d1b1/Sh2d1b2tm1.1Cpt
Genetic Background: involves: 129S4/SvJae * BALB/cJ

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Usf1tm1Svl/Usf1+,Usf2tm1Svl/Usf2+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6J

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Sh2d1b1/Sh2d1b2tm1.1Cpt/Sh2d1b1/Sh2d1b2tm1.1Cpt
Genetic Background: involves: BALB/cJ

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Tg(Hoxb7-cre)5526Cmb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Sh2d1atm1Vei/Sh2d1atm1Vei,Sh2d1b1tm3Vei/Sh2d1b1tm3Vei
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Sh2d1atm1Pls/Sh2d1atm1Pls,Sh2d1b1tm3Vei/Sh2d1b1tm3Vei
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015314 Q9ET39 / Slamf6 / SLAM family member 6 / Q96DU3*  / reaction / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr