ENSMUSG00000015314


Mus musculus

Features
Gene ID: ENSMUSG00000015314
  
Biological name :Slamf6
  
Synonyms : Q9ET39 / Slamf6 / SLAM family member 6
  
Possible biological names infered from orthology : Q96DU3
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H3
Gene start: 171917515
Gene end: 171953170
  
Corresponding Affymetrix probe sets: 10351691 (MoGene1.0st)   1420659_at (Mouse Genome 430 2.0 Array)   1425086_a_at (Mouse Genome 430 2.0 Array)   1457773_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000130610
Ensembl peptide - ENSMUSP00000141448
Ensembl peptide - ENSMUSP00000141944
Ensembl peptide - ENSMUSP00000142242
NCBI entrez gene - 30925     See in Manteia.
MGI - MGI:1353620
RefSeq - XM_011238825
RefSeq - NM_030710
RefSeq - XM_006496884
RefSeq - XM_006496885
RefSeq - XM_006496886
RefSeq - XM_006496887
RefSeq - XM_011238824
RefSeq Peptide - NP_001334116
RefSeq Peptide - NP_001334115
RefSeq Peptide - NP_109635
swissprot - Q9ET39
swissprot - Q18PJ0
swissprot - A0A0A6YY21
swissprot - Q18PG5
Ensembl - ENSMUSG00000015314
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q96DU3ENSG00000162739Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ly9 / Q01965 / T-lymphocyte surface antigen Ly-9 / Q9HBG7* / lymphocyte antigen 9*ENSMUSG0000000470724
Cd84 / CD84 antigen / Q9UIB8* / CD84 molecule*ENSMUSG0000003814723
Slamf9 / SLAM family member 9 / Q96A28*ENSMUSG0000002654821
Slamf7 / SLAM family member 7 / Q9NQ25*ENSMUSG0000003817920


Protein motifs (from Interpro)
Interpro ID Name
 IPR007110  Immunoglobulin-like domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001779 natural killer cell differentiation IMP
 biological_processGO:0001787 natural killer cell proliferation IMP
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0032729 positive regulation of interferon-gamma production ISO
 biological_processGO:0032740 positive regulation of interleukin-17 production ISO
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045954 positive regulation of natural killer cell mediated cytotoxicity ISO
 biological_processGO:0072540 T-helper 17 cell lineage commitment ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Baxtm1Dlo/Baxtm1Dlo,Bcl2l1tm1Dlo/Bcl2l1tm1Dlo
Genetic Background: involves: 129P2/OlaHsd

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mafatm1Staka/Mafa+
Genetic Background: involves: ICR

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mafatm1Staka/Mafa+
Genetic Background: involves: ICR

 MP:0005026 decreased susceptibility to parasitic infection "reduced likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mafatm1Staka/Mafa+
Genetic Background: involves: ICR

 MP:0005074 defective granulocyte bactericidal activity "inability or reduced ability of neutrophils, eosinophils, or basophils to kill bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:5405]
Show

Allelic Composition: Mafatm1Staka/Mafa+
Genetic Background: involves: ICR

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mafatm1Staka/Mafa+
Genetic Background: involves: ICR

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Mafatm1Staka/Mafa+
Genetic Background: involves: ICR

 MP:0008632 increased circulating interleukin-16 level "increase in the amount in the blood of a cytokine produced by activated T-cells that stimulates the migration of CD4-positive lymphocytes and monocytes" [MESH:D12.644.276.374.465.516]
Show

Allelic Composition: Mafatm1Staka/Mafa+
Genetic Background: involves: ICR

 MP:0008647 increased circulating interleukin-12b level "increase in the amount in the blood of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
Show

Allelic Composition: Mafatm1Staka/Mafa+
Genetic Background: involves: ICR

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Mafatm1Staka/Mafa+
Genetic Background: involves: ICR

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mafatm1Staka/Mafa+
Genetic Background: involves: ICR

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005696 O88890 / Sh2d1a / SH2 domain-containing protein 1A / O60880* / SH2 domain containing 1A*  / reaction / complex
 ENSMUSG00000073494 Q45HK4 / Sh2d1b2 / SH2 domain-containing protein 1B2 / SH2D1B* / O14796* / SH2 domain containing 1B*  / complex / reaction
 ENSMUSG00000015314 Q9ET39 / Slamf6 / SLAM family member 6 / Q96DU3*  / reaction / complex
 ENSMUSG00000102418 Sh2d1b1 / SH2 domain containing 1B1 / O14796* / SH2D1B* / SH2 domain containing 1B*  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr