ENSDARG00000001303


Danio rerio

Features
Gene ID: ENSDARG00000001303
  
Biological name :psmb8a
  
Synonyms : proteasome subunit beta 8A / psmb8a
  
Possible biological names infered from orthology : P28062 / P28063 / proteasome subunit beta 8 / Proteasome subunit beta type-8 / PSMB8
  
Species: Danio rerio
  
Chr. number: 19
Strand: -1
Band:
Gene start: 7105838
Gene end: 7144548
  
Corresponding Affymetrix probe sets: Dr.7957.1.S1_at (Zebrafish Array)   NM_131392_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000095608
Ensembl peptide - ENSDARP00000126012
NCBI entrez gene - 30666     See in Manteia.
RefSeq - NM_131392
RefSeq Peptide - NP_571467
swissprot - I3ISW4
swissprot - O57330
ZFIN ID - ZDB-GENE-990415-141
Ensembl - ENSDARG00000001303
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PSMB8ENSG00000204264Homo sapiens
 Psmb8ENSMUSG00000024338Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
psmb5 / proteasome subunit beta 5 / O55234* / P28074* / Proteasome subunit beta type-5 *ENSDARG0000007544554
psmb11b / proteasome subunit beta11b / A5LHX3* / PSMB11* / proteasome subunit beta 11*ENSDARG0000006808638
psmb11a / proteasome subunit beta 11a / A5LHX3* / PSMB11* / proteasome subunit beta 11*ENSDARG0000010853035


Protein motifs (from Interpro)
Interpro ID Name
 IPR000243  Peptidase T1A, proteasome beta-subunit
 IPR001353  Proteasome, subunit alpha/beta
 IPR016050  Proteasome beta-type subunit, conserved site
 IPR023333  Proteasome B-type subunit
 IPR029055  Nucleophile aminohydrolases, N-terminal
 IPR035705  Proteasome subunit beta type-8


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IEA
 cellular_componentGO:0000502 proteasome complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005839 proteasome core complex IEA
 molecular_functionGO:0004175 endopeptidase activity IEA
 molecular_functionGO:0004298 threonine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
ABC-family proteins mediated transport
FCERI mediated NF-kB activation
The role of GTSE1 in G2/M progression after G2 checkpoint
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Antigen processing: Ubiquitination & Proteasome degradation
Regulation of RUNX2 expression and activity
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Degradation of GLI1 by the proteasome
SCF(Skp2)-mediated degradation of p27/p21
Regulation of ornithine decarboxylase (ODC)
Regulation of RAS by GAPs
Asymmetric localization of PCP proteins
Autodegradation of Cdh1 by Cdh1:APC/C
Degradation of beta-catenin by the destruction complex
Autodegradation of the E3 ubiquitin ligase COP1
APC/C:Cdc20 mediated degradation of Securin
G2/M Checkpoints
CDT1 association with the CDC6:ORC:origin complex
Dectin-1 mediated noncanonical NF-kB signaling
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Activation of NF-kappaB in B cells
AUF1 (hnRNP D0) binds and destabilizes mRNA
CDK-mediated phosphorylation and removal of Cdc6
CLEC7A (Dectin-1) signaling
Cross-presentation of soluble exogenous antigens (endosomes)
Degradation of AXIN
Degradation of DVL
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Downstream TCR signaling
Hedgehog on state
Interleukin-1 signaling
MAPK6/MAPK4 signaling
Neddylation
NIK-->noncanonical NF-kB signaling
Orc1 removal from chromatin
Regulation of PTEN stability and activity
Regulation of RUNX3 expression and activity
Separation of Sister Chromatids
TNFR2 non-canonical NF-kB pathway
UCH proteinases
Ub-specific processing proteases
Ubiquitin-dependent degradation of Cyclin D1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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