ENSDARG00000002795


Danio rerio

Features
Gene ID: ENSDARG00000002795
  
Biological name :meis3
  
Synonyms : meis3 / myeloid ecotropic viral integration site 3
  
Possible biological names infered from orthology : Homeobox protein Meis3 / Meis homeobox 3 / P97368 / Q99687
  
Species: Danio rerio
  
Chr. number: 15
Strand: -1
Band:
Gene start: 6838039
Gene end: 6863317
  
Corresponding Affymetrix probe sets: Dr.1680.1.S1_at (Zebrafish Array)   NM_131778_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000024365
Ensembl peptide - ENSDARP00000128544
Ensembl peptide - ENSDARP00000129275
NCBI entrez gene - 81885     See in Manteia.
RefSeq - NM_131778
RefSeq Peptide - NP_571853
swissprot - Q90ZE3
swissprot - X1WE93
ZFIN ID - ZDB-GENE-010406-2
Ensembl - ENSDARG00000002795
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MEIS3ENSG00000105419Homo sapiens
 Meis3ENSMUSG00000041420Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
meis2a / meis2b / Meis homeobox 2bENSDARG0000007784058
meis2a / Meis homeobox 2a / MEIS2* / P97367* / O14770* / Meis homeobox 2* / Homeobox protein Meis2 *ENSDARG0000009824058
meis1b / Meis homeobox 1 b / MEIS1* / Q60954* / O00470* / Meis homeobox 1* / Homeobox protein Meis1 *ENSDARG0000001207857
meis1a / Meis homeobox 1 a / MEIS1* / Q60954* / O00470* / Meis homeobox 1* / Homeobox protein Meis1 *ENSDARG0000000293755
pknox2 / pbx/knotted 1 homeobox 2 / Q8BG99* / Q96KN3* / Homeobox protein PKNOX2 *ENSDARG0000005534933
pknox1.1 / pbx/knotted 1 homeobox 1.1 / O70477* / P55347* / PKNOX1* / PBX/knotted 1 homeobox 1* / Homeobox protein PKNOX1 *ENSDARG0000001876532
pknox1.2 / pbx/knotted 1 homeobox 1.2 / O70477* / P55347* / PKNOX1* / PBX/knotted 1 homeobox 1* / Homeobox protein PKNOX1 *ENSDARG0000003654232
tgif1 / TGFB-induced factor homeobox 1 / P70284* / Q15583*ENSDARG0000005933713
FO834857.1 / TGIF2* / Q9GZN2* / TGFB induced factor homeobox 2*ENSDARG0000011289510


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR008422  Homeobox KN domain
 IPR009057  Homeobox-like domain superfamily
 IPR032453  Homeobox protein PKNOX/Meis, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0030902 hindbrain development IGI
 biological_processGO:0031016 pancreas development IMP
 biological_processGO:0031017 exocrine pancreas development IMP
 biological_processGO:0035066 positive regulation of histone acetylation IGI
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IGI
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0048484 enteric nervous system development IMP
 biological_processGO:1901166 neural crest cell migration involved in autonomic nervous system development IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000017 endoderm endoderm absent , abnormal
Show

 ZFA:0000112 gut gut enteric neuron decreased amount , abnormal
gut anatomical region has fewer parts of type neural crest cell , abnormal
Show

 ZFA:0000393 mesenchyme mesenchyme increased distribution , abnormal
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 ZFA:0000706 posterior intestine posterior intestine enteric neuron absent , abnormal
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 ZFA:0001076 intestinal bulb intestinal bulb enteric neuron decreased amount , abnormal
intestinal bulb anatomical region position , ameliorated
intestinal bulb anatomical region increased distribution , abnormal
intestinal bulb in_left_side_of mislocalised , abnormal
intestinal bulb in_right_side_of mislocalised , abnormal
intestinal bulb anatomical region lacks all parts of type neural crest cell , abnormal
Show

 ZFA:0001155 enteric nervous system enteric nervous system neural crest cell decreased amount , abnormal
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 ZFA:0001260 endocrine pancreas endocrine pancreas mislocalised anteriorly , abnormal
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 ZFA:0001323 mid intestine mid intestine enteric neuron decreased amount , abnormal
mid intestine in_left_side_of absent , abnormal
mid intestine in_right_side_of absent , abnormal
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 ZFA:0001383 fin bud fin bud absent , abnormal
fin bud decreased amount , abnormal
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 ZFA:0005738 intestinal bulb primordium intestinal bulb primordium decreased amount , abnormal
intestinal bulb primordium anatomical region absent , abnormal
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 ZFA:0007067 vagal ganglion vagal ganglion anatomical region mislocalised , abnormal
Show

 ZFA:0009078 gut endothelial cell gut endothelial cell absent , abnormal
Show

 ZFA:0009165 neural crest cell neural crest cell cell proliferation decreased process quality , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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