ENSDARG00000003971


Danio rerio

Features
Gene ID: ENSDARG00000003971
  
Biological name :isl2a
  
Synonyms : isl2a / ISL LIM homeobox 2a / P53406
  
Possible biological names infered from orthology : Insulin enhancer protein ISL-2 / ISL2 / ISL LIM homeobox 2 / Q96A47 / Q9CXV0
  
Species: Danio rerio
  
Chr. number: 25
Strand: -1
Band:
Gene start: 32746014
Gene end: 32751982
  
Corresponding Affymetrix probe sets: Dr.281.1.S1_at (Zebrafish Array)   NM_130970_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000020636
NCBI entrez gene - 30157     See in Manteia.
RefSeq - NM_130970
RefSeq Peptide - NP_571045
swissprot - B3DH43
swissprot - P53406
ZFIN ID - ZDB-GENE-980526-562
Ensembl - ENSDARG00000003971
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ISL2ENSGALG00000033391Gallus gallus
 ISL2ENSG00000159556Homo sapiens
 Isl2ENSMUSG00000032318Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
isl2b / P53407 / ISL LIM homeobox 2b / ISL2* / Q9CXV0* / Q96A47* / ISL LIM homeobox 2* / Insulin enhancer protein ISL-2 *ENSDARG0000005349989
isl1 / P53405 / ISL LIM homeobox 1 / P61371* / P61372* / Insulin enhancer protein ISL-1 *ENSDARG0000000402375
isl1l / islet1, likeENSDARG0000002105547
lmx1ba / LIM homeobox transcription factor 1, beta a / LMX1B* / O60663* / LIM homeobox transcription factor 1 beta*ENSDARG0000010481530
lmx1al / LIM homeobox transcription factor 1, alpha-likeENSDARG0000007791529
lhx1a / Q90476 / LIM homeobox 1a / LHX1* / P48742* / P63006* / LIM homeobox 1* / LIM/homeobox protein Lhx1 *ENSDARG0000001401828
lmx1a / LIM homeobox transcription factor 1, alpha / Q8TE12* / Q9JKU8*ENSDARG0000002035428
lhx2b / LIM homeobox 2bENSDARG0000003122228
lhx9 / Q1LWV4 / LIM homeobox 9 / Q9WUH2* / Q9NQ69* / LIM/homeobox protein Lhx9 *ENSDARG0000005697928
lhx5 / P52889 / LIM homeobox 5 / Q9H2C1* / P61375* / LIM homeobox protein 5*ENSDARG0000005793628
lmx1bb / LIM homeobox transcription factor 1, beta b / LMX1B* / O60663* / LIM homeobox transcription factor 1 beta*ENSDARG0000006836528
lhx1b / LIM homeobox 1b / LHX1* / P48742* / P63006* / LIM homeobox 1* / LIM/homeobox protein Lhx1 *ENSDARG0000000794427
LHX3 / LIM homeobox 3 / Q9UBR4*ENSDARG0000000380326
lhx4 / LIM homeobox 4 / P53776* / Q969G2* / LIM/homeobox protein Lhx4 *ENSDARG0000003945826
lhx8a / LIM homeobox 8a / LHX8* / O35652* / Q68G74* / LIM homeobox 8* / LIM/homeobox protein Lhx8 *ENSDARG0000000233025
lhx6 / LIM homeobox 6 / Q9R1R0* / Q9UPM6* / Mus musculus LIM homeobox protein 6 (Lhx6), transcript variant 5, mRNA.*ENSDARG0000000689625
lhx2a / LIM homeobox 2aENSDARG0000003796423
lhx8b / LIM homeobox 8b / LHX8* / O35652* / Q68G74* / LIM homeobox 8* / LIM/homeobox protein Lhx8 *ENSDARG0000004214523
si:ch211-236k19.2 / LHX6* / Q9R1R0* / Q9UPM6* / LIM homeobox 6* / Mus musculus LIM homeobox protein 6 (Lhx6), transcript variant 5, mRNA.*ENSDARG0000005216521
lmo4b / LIM domain only 4b / LMO4* / P61968* / P61969* / LIM domain only 4* / LIM domain transcription factor LMO4 *ENSDARG0000005474917


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR001781  Zinc finger, LIM-type
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007409 axonogenesis IMP
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0031017 exocrine pancreas development IGI
 biological_processGO:0035476 angioblast cell migration IMP
 biological_processGO:0048665 neuron fate specification IMP
 biological_processGO:0048675 axon extension IMP
 biological_processGO:0048845 venous blood vessel morphogenesis IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000014 dorsal aorta dorsal aorta mislocalised , abnormal
Show

 ZFA:0000477 posterior cardinal vein posterior cardinal vein decreased distribution , abnormal
posterior cardinal vein blood vessel endothelial cell decreased amount , abnormal
Show

 ZFA:0001061 intersegmental artery intersegmental artery sprouting angiogenesis decreased process quality , abnormal
intersegmental artery blood vessel endothelial cell decreased amount , abnormal
intersegmental artery blood vessel endothelial cell amount , ameliorated
Show

 ZFA:0001094 whole organism whole organism decreased amount , abnormal
whole organism viability , abnormal
whole organism decreased life span , abnormal
Show

 ZFA:0005040 posterior lateral mesoderm posterior lateral mesoderm angioblastic mesenchymal cell spatial pattern , abnormal
Show

 ZFA:0009243 CaP motoneuron CaP motoneuron axon guidance physical quality of a process , abnormal
CaP motoneuron axon truncated , abnormal
CaP motoneuron axon branchiness , abnormal
CaP motoneuron axon extension decreased process quality , abnormal
CaP motoneuron axon decreased length , abnormal
Show

 ZFA:0009247 secondary motor neuron secondary motor neuron decreased amount , abnormal
secondary motor neuron axon decreased amount , abnormal
secondary motor neuron absent , abnormal
Show

 ZFA:0009258 angioblastic mesenchymal cell angioblastic mesenchymal cell irregular spatial pattern , abnormal
angioblastic mesenchymal cell mislocalised , abnormal
angioblastic mesenchymal cell decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr