ENSDARG00000031222


Danio rerio

Features
Gene ID: ENSDARG00000031222
  
Biological name :lhx2b
  
Synonyms : lhx2b / LIM homeobox 2b
  
Possible biological names infered from orthology :
  
Species: Danio rerio
  
Chr. number: 8
Strand: 1
Band:
Gene start: 3085120
Gene end: 3101392
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000120466
Ensembl peptide - ENSDARP00000123264
NCBI entrez gene - 791744     See in Manteia.
RefSeq - NM_001040010
RefSeq Peptide - NP_001035099
swissprot - F6NJE9
swissprot - B0R107
ZFIN ID - ZDB-GENE-051220-1
Ensembl - ENSDARG00000031222
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LHX2ENSGALG00000001124Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
lhx9 / Q1LWV4 / LIM homeobox 9 / Q9WUH2* / Q9NQ69* / LIM/homeobox protein Lhx9 *ENSDARG0000005697966
lhx2a / LIM homeobox 2aENSDARG0000003796443
lhx6 / LIM homeobox 6 / Q9R1R0* / Q9UPM6* / Mus musculus LIM homeobox protein 6 (Lhx6), transcript variant 5, mRNA.*ENSDARG0000000689627
lhx8a / LIM homeobox 8a / LHX8* / O35652* / Q68G74* / LIM homeobox 8* / LIM/homeobox protein Lhx8 *ENSDARG0000000233024
lhx1a / Q90476 / LIM homeobox 1a / LHX1* / P48742* / P63006* / LIM homeobox 1* / LIM/homeobox protein Lhx1 *ENSDARG0000001401824
lhx5 / P52889 / LIM homeobox 5 / Q9H2C1* / P61375* / LIM homeobox protein 5*ENSDARG0000005793624
isl2a / P53406 / ISL LIM homeobox 2a / ISL2* / Q96A47* / ISL LIM homeobox 2*ENSDARG0000000397123
isl2b / P53407 / ISL LIM homeobox 2b / ISL2* / Q9CXV0* / Q96A47* / ISL LIM homeobox 2* / Insulin enhancer protein ISL-2 *ENSDARG0000005349923
lhx1b / LIM homeobox 1b / LHX1* / P48742* / P63006* / LIM homeobox 1* / LIM/homeobox protein Lhx1 *ENSDARG0000000794422
lmx1a / LIM homeobox transcription factor 1, alpha / Q8TE12* / Q9JKU8*ENSDARG0000002035422
lmx1bb / LIM homeobox transcription factor 1, beta b / LMX1B* / O60663* / LIM homeobox transcription factor 1 beta*ENSDARG0000006836522
lmx1al / LIM homeobox transcription factor 1, alpha-likeENSDARG0000007791522
lmx1ba / LIM homeobox transcription factor 1, beta a / LMX1B* / O60663* / LIM homeobox transcription factor 1 beta*ENSDARG0000010481522
isl1 / P53405 / ISL LIM homeobox 1 / P61371* / P61372* / Insulin enhancer protein ISL-1 *ENSDARG0000000402321
lhx4 / LIM homeobox 4 / P53776* / Q969G2* / LIM/homeobox protein Lhx4 *ENSDARG0000003945821
LHX3 / LIM homeobox 3 / Q9UBR4*ENSDARG0000000380320
si:ch211-236k19.2 / LHX6* / Q9R1R0* / Q9UPM6* / LIM homeobox 6* / Mus musculus LIM homeobox protein 6 (Lhx6), transcript variant 5, mRNA.*ENSDARG0000005216520
lhx8b / LIM homeobox 8b / LHX8* / O35652* / Q68G74* / LIM homeobox 8* / LIM/homeobox protein Lhx8 *ENSDARG0000004214519
isl1l / islet1, likeENSDARG0000002105518
lmo4a / LIM domain only 4aENSDARG0000001385315


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR001781  Zinc finger, LIM-type
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0007420 brain development IMP
 biological_processGO:0007634 optokinetic behavior IMP
 biological_processGO:0009416 response to light stimulus IMP
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0021537 telencephalon development IMP
 biological_processGO:0021554 optic nerve development IMP
 biological_processGO:0021794 thalamus development IGI
 biological_processGO:0030900 forebrain development IMP
 biological_processGO:0031290 retinal ganglion cell axon guidance IMP
 biological_processGO:0043010 camera-type eye development IMP
 biological_processGO:0071632 optomotor response IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000035 lens lens increased distance retinal pigmented epithelium , abnormal
lens increased distance iridophore , abnormal
Show

 ZFA:0000059 postoptic commissure postoptic commissure aplastic , abnormal
Show

 ZFA:0000107 eye eye movement quality , abnormal
eye degree of pigmentation , abnormal
eye neoplastic , abnormal
eye neoplasm protruding , abnormal
Show

 ZFA:0000144 retinal pigmented epithelium retinal pigmented epithelium dislocated lens , abnormal
retinal pigmented epithelium organization quality , abnormal
retinal pigmented epithelium spatial pattern , abnormal
Show

 ZFA:0000396 nervous system nervous system quality , abnormal
Show

 ZFA:0000418 pretectum pretectum cell mislocalised , abnormal
Show

 ZFA:0000509 epithalamus epithalamus increased size , abnormal
Show

 ZFA:0000556 optic chiasm optic chiasm aplastic , abnormal
optic chiasm absent , abnormal
Show

 ZFA:0000653 dorsal thalamus dorsal thalamus GABAergic neuron mislocalised posteriorly , abnormal
dorsal thalamus cellular quality , abnormal
dorsal thalamus cell mislocalised , abnormal
dorsal thalamus fused with pretectum , abnormal
dorsal thalamus CNS neuron (sensu Vertebrata) poorly differentiated , abnormal
Show

 ZFA:0001094 whole organism whole organism quality , abnormal
whole organism balance , abnormal
whole organism movement behavioral quality , abnormal
whole organism increased pigmentation , abnormal
Show

 ZFA:0009090 pigment cell pigment cell quality , abnormal
Show

 ZFA:0009310 retinal ganglion cell retinal ganglion cell axon misrouted , abnormal
retinal ganglion cell axon ipsilateral to brain ipsilateral region, abnormal
retinal ganglion cell axon ipsilateral to eye , abnormal
retinal ganglion cell axon displaced to diencephalon , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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