ENSDARG00000004184


Danio rerio

Features
Gene ID: ENSDARG00000004184
  
Biological name :nf1b
  
Synonyms : neurofibromin 1b / nf1b
  
Possible biological names infered from orthology : Neurofibromin / neurofibromin 1 / NF1 / P21359 / Q04690
  
Species: Danio rerio
  
Chr. number: 10
Strand: 1
Band:
Gene start: 37268854
Gene end: 37394957
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000119608
NCBI entrez gene - 564518     See in Manteia.
swissprot - E7FFY1
ZFIN ID - ZDB-GENE-091111-4
Ensembl - ENSDARG00000004184
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NF1ENSGALG00000005660Gallus gallus
 NF1ENSG00000196712Homo sapiens
 Nf1ENSMUSG00000020716Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
nf1a / neurofibromin 1a / NF1* / P21359* / Q04690* / Neurofibromin * / neurofibromin 1*ENSDARG0000001298288


Protein motifs (from Interpro)
Interpro ID Name
 IPR001251  CRAL-TRIO lipid binding domain
 IPR001936  Ras GTPase-activating domain
 IPR008936  Rho GTPase activation protein
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR023152  Ras GTPase-activating protein, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0007613 memory IMP
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045685 regulation of glial cell differentiation IGI
 biological_processGO:0046580 negative regulation of Ras protein signal transduction IBA
 biological_processGO:0046959 habituation IGI
 biological_processGO:0060251 regulation of glial cell proliferation IGI
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0070444 oligodendrocyte progenitor proliferation IMP
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane IBA
 molecular_functionGO:0005096 GTPase activator activity IBA


Pathways (from Reactome)
Pathway description
Regulation of RAS by GAPs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000012 central nervous system central nervous system oligodendrocyte poorly differentiated , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000075 spinal cord spinal cord has extra parts of type glioblast (sensu Vertebrata) , abnormal
spinal cord glioblast (sensu Vertebrata) proliferative , abnormal
spinal cord white matter molecular quality , abnormal
spinal cord myelin sheath loose , abnormal
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 ZFA:0000944 posterior lateral line posterior lateral line immature Schwann cell differentiated , abnormal
posterior lateral line has extra parts of type immature Schwann cell , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel aplastic , abnormal
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 ZFA:0001345 interrenal gland interrenal gland neuroblastoma increased occurrence , abnormal
interrenal gland neuroblastoma increased occurrence , exacerbated
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 ZFA:0001572 superior cervical ganglion superior cervical ganglion cell increased amount , abnormal
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 ZFA:0005061 ventricular myocardium ventricular myocardium decreased thickness , abnormal
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 ZFA:0005064 atrioventricular valve atrioventricular valve decreased functionality , abnormal
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 ZFA:0005223 lateral larval melanophore stripe lateral larval melanophore stripe has fewer parts of type melanocyte , abnormal
lateral larval melanophore stripe melanocyte spatial pattern , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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