ENSDARG00000012982


Danio rerio

Features
Gene ID: ENSDARG00000012982
  
Biological name :nf1a
  
Synonyms : neurofibromin 1a / nf1a
  
Possible biological names infered from orthology : Neurofibromin / neurofibromin 1 / NF1 / P21359 / Q04690
  
Species: Danio rerio
  
Chr. number: 15
Strand: -1
Band:
Gene start: 30861647
Gene end: 30984804
  
Corresponding Affymetrix probe sets: Dr.2156.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000128480
Ensembl peptide - ENSDARP00000074778
Ensembl peptide - ENSDARP00000128039
swissprot - E7FBD0
swissprot - X1WCU2
swissprot - X1WE29
ZFIN ID - ZDB-GENE-030131-4907
Ensembl - ENSDARG00000012982
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NF1ENSGALG00000005660Gallus gallus
 NF1ENSG00000196712Homo sapiens
 Nf1ENSMUSG00000020716Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
nf1b / neurofibromin 1b / NF1* / P21359* / Q04690* / Neurofibromin * / neurofibromin 1*ENSDARG0000000418488


Protein motifs (from Interpro)
Interpro ID Name
 IPR001251  CRAL-TRIO lipid binding domain
 IPR001936  Ras GTPase-activating domain
 IPR008936  Rho GTPase activation protein
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR023152  Ras GTPase-activating protein, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0007613 memory IMP
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045685 regulation of glial cell differentiation IGI
 biological_processGO:0046580 negative regulation of Ras protein signal transduction IBA
 biological_processGO:0046959 habituation IGI
 biological_processGO:0051726 regulation of cell cycle IMP
 biological_processGO:0060251 regulation of glial cell proliferation IGI
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0070444 oligodendrocyte progenitor proliferation IMP
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane IBA
 molecular_functionGO:0005096 GTPase activator activity IBA


Pathways (from Reactome)
Pathway description
Regulation of RAS by GAPs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel morphology , abnormal
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 ZFA:0001345 interrenal gland interrenal gland neuroblastoma increased occurrence , abnormal
interrenal gland neuroblastoma increased occurrence , exacerbated
interrenal gland neuroblastoma amount , ameliorated
interrenal gland neuroblastoma increased amount , abnormal
interrenal gland neuroblastoma decreased amount , abnormal
interrenal gland neuroblastoma increased occurrence , ameliorated
Show

 ZFA:0001572 superior cervical ganglion superior cervical ganglion cell increased amount , abnormal
Show

 ZFA:0005064 atrioventricular valve atrioventricular valve decreased functionality , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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