ENSGALG00000005660


Gallus gallus

Features
Gene ID: ENSGALG00000005660
  
Biological name :NF1
  
Synonyms : neurofibromin 1 / NF1
  
Possible biological names infered from orthology : Neurofibromin / P21359 / Q04690
  
Species: Gallus gallus
  
Chr. number: 19
Strand: -1
Band:
Gene start: 9026613
Gene end: 9106170
  
Corresponding Affymetrix probe sets: Gga.12322.1.S1_at (Chicken Array)   Gga.3311.1.S1_at (Chicken Array)   GgaAffx.3505.1.S1_at (Chicken Array)   GgaAffx.3517.1.S1_at (Chicken Array)   GgaAffx.3520.1.S1_at (Chicken Array)   GgaAffx.3551.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000009067
Ensembl peptide - ENSGALP00000058257
Ensembl peptide - ENSGALP00000057298
Ensembl peptide - ENSGALP00000049700
Ensembl peptide - ENSGALP00000047062
Ensembl peptide - ENSGALP00000046637
NCBI entrez gene - 396085     See in Manteia.
RefSeq - XM_415914
RefSeq - XM_004946785
RefSeq - XM_015295852
RefSeq - XM_015295853
RefSeq - XM_015295854
RefSeq - XM_015295855
RefSeq - XM_015295856
RefSeq - XM_003642416
swissprot - A0A1D5PZ49
swissprot - A0A1D5PWG6
swissprot - A0A1D5PAD7
swissprot - A0A1D5P310
swissprot - A0A1D5P1U6
swissprot - E1C9F6
Ensembl - ENSGALG00000005660
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nf1aENSDARG00000012982Danio rerio
 nf1bENSDARG00000004184Danio rerio
 NF1ENSG00000196712Homo sapiens
 Nf1ENSMUSG00000020716Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001251  CRAL-TRIO lipid binding domain
 IPR001936  Ras GTPase-activating domain
 IPR008936  Rho GTPase activation protein
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR023152  Ras GTPase-activating protein, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0001656 metanephros development IEA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001889 liver development IEA
 biological_processGO:0001937 negative regulation of endothelial cell proliferation IEA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0001952 regulation of cell-matrix adhesion IEA
 biological_processGO:0001953 negative regulation of cell-matrix adhesion IEA
 biological_processGO:0006469 negative regulation of protein kinase activity IEA
 biological_processGO:0007154 cell communication IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007265 Ras protein signal transduction IEA
 biological_processGO:0007406 negative regulation of neuroblast proliferation IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007422 peripheral nervous system development IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007519 skeletal muscle tissue development IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0008542 visual learning IEA
 biological_processGO:0008625 extrinsic apoptotic signaling pathway via death domain receptors IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0014044 Schwann cell development IEA
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0021510 spinal cord development IEA
 biological_processGO:0021764 amygdala development IEA
 biological_processGO:0021897 forebrain astrocyte development IEA
 biological_processGO:0021915 neural tube development IEA
 biological_processGO:0021987 cerebral cortex development IEA
 biological_processGO:0022011 myelination in peripheral nervous system IEA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0030198 extracellular matrix organization IEA
 biological_processGO:0030199 collagen fibril organization IEA
 biological_processGO:0030325 adrenal gland development IEA
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0032228 regulation of synaptic transmission, GABAergic IEA
 biological_processGO:0034605 cellular response to heat IEA
 biological_processGO:0035021 negative regulation of Rac protein signal transduction IEA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042992 obsolete negative regulation of transcription factor import into nucleus IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0043407 negative regulation of MAP kinase activity IEA
 biological_processGO:0043408 regulation of MAPK cascade IEA
 biological_processGO:0043409 negative regulation of MAPK cascade IEA
 biological_processGO:0043473 pigmentation IEA
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0043535 regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045124 regulation of bone resorption IEA
 biological_processGO:0045671 negative regulation of osteoclast differentiation IEA
 biological_processGO:0045685 regulation of glial cell differentiation IEA
 biological_processGO:0045762 positive regulation of adenylate cyclase activity IEA
 biological_processGO:0045765 regulation of angiogenesis IEA
 biological_processGO:0046580 negative regulation of Ras protein signal transduction IEA
 biological_processGO:0046929 negative regulation of neurotransmitter secretion IEA
 biological_processGO:0048147 negative regulation of fibroblast proliferation IEA
 biological_processGO:0048169 regulation of long-term neuronal synaptic plasticity IEA
 biological_processGO:0048485 sympathetic nervous system development IEA
 biological_processGO:0048593 camera-type eye morphogenesis IEA
 biological_processGO:0048712 negative regulation of astrocyte differentiation IEA
 biological_processGO:0048715 negative regulation of oligodendrocyte differentiation IEA
 biological_processGO:0048745 smooth muscle tissue development IEA
 biological_processGO:0048820 hair follicle maturation IEA
 biological_processGO:0048844 artery morphogenesis IEA
 biological_processGO:0048853 forebrain morphogenesis IEA
 biological_processGO:0050890 cognition IEA
 biological_processGO:0061534 gamma-aminobutyric acid secretion, neurotransmission IEA
 biological_processGO:0061535 glutamate secretion, neurotransmission IEA
 biological_processGO:0098597 observational learning IEA
 biological_processGO:1900271 regulation of long-term synaptic potentiation IEA
 biological_processGO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
 biological_processGO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0008429 phosphatidylethanolamine binding IEA
 molecular_functionGO:0031210 phosphatidylcholine binding IEA


Pathways (from Reactome)
Pathway description
Regulation of RAS by GAPs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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