ENSDARG00000004537


Danio rerio

Features
Gene ID: ENSDARG00000004537
  
Biological name :kmt2a
  
Synonyms : kmt2a / lysine (K)-specific methyltransferase 2A
  
Possible biological names infered from orthology : lysine methyltransferase 2A / Mus musculus lysine (K)-specific methyltransferase 2A (Kmt2a), transcript variant 1, mRNA. / P55200 / Q03164
  
Species: Danio rerio
  
Chr. number: 15
Strand: -1
Band:
Gene start: 23382199
Gene end: 23420170
  
Corresponding Affymetrix probe sets: Dr.19684.1.A1_at (Zebrafish Array)   Dr.7456.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000123761
Ensembl peptide - ENSDARP00000095298
NCBI entrez gene - 557048     See in Manteia.
RefSeq - NM_001110279
RefSeq Peptide - NP_001103749
swissprot - F8W578
swissprot - F1QL52
ZFIN ID - ZDB-GENE-080521-3
Ensembl - ENSDARG00000004537
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000006818Gallus gallus
 KMT2AENSG00000118058Homo sapiens
 Kmt2aENSMUSG00000002028Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
kmt2bb / lysine (K)-specific methyltransferase 2Bb / KMT2B* / O08550* / Q9UMN6* / lysine methyltransferase 2B* / Histone-lysine N-methyltransferase 2B *ENSDARG0000006069721
kmt2ba / lysine (K)-specific methyltransferase 2Ba / KMT2B* / O08550* / Q9UMN6* / lysine methyltransferase 2B* / Histone-lysine N-methyltransferase 2B *ENSDARG0000006296220
kmt2ca / lysine (K)-specific methyltransferase 2Ca / KMT2C* / Q8NEZ4* / lysine methyltransferase 2C*ENSDARG0000007931211
kmt2cb / lysine (K)-specific methyltransferase 2Cb / KMT2C* / Q8NEZ4* / lysine methyltransferase 2C*ENSDARG0000007556010
kmt2d / lysine (K)-specific methyltransferase 2D / O14686* / Q6PDK2* / lysine methyltransferase 2D* / Histone-lysine N-methyltransferase 2D *ENSDARG000000370606
setd1a / SET domain containing 1A / O15047* / AC149222.1*ENSDARG000000600306
setd1ba / SET domain containing 1B, a / Q9UPS6* / SETD1B* / Q8CFT2* / SET domain containing 1B* / Histone-lysine N-methyltransferase SETD1B *ENSDARG000000608476
setd1bb / SET domain containing 1B, bENSDARG000000772443


Protein motifs (from Interpro)
Interpro ID Name
 IPR001214  SET domain
 IPR001487  Bromodomain
 IPR001965  Zinc finger, PHD-type
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR002857  Zinc finger, CXXC-type
 IPR003616  Post-SET domain
 IPR003888  FY-rich, N-terminal
 IPR003889  FY-rich, C-terminal
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR016569  Methyltransferase, trithorax
 IPR019787  Zinc finger, PHD-finger
 IPR034732  Extended PHD (ePHD) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0021782 glial cell development IMP
 biological_processGO:0022008 neurogenesis IMP
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0032259 methylation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0048339 paraxial mesoderm development IGI
 biological_processGO:0048823 nucleate erythrocyte development IMP
 biological_processGO:0051568 histone H3-K4 methylation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0035097 histone methyltransferase complex IEA
 cellular_componentGO:0071339 MLL1 complex IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity IEA
 molecular_functionGO:0042800 histone methyltransferase activity (H3-K4 specific) IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain morphology , abnormal
brain malformed , abnormal
brain lacks parts or has fewer parts of type oligodendrocyte , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000142 peripheral nervous system peripheral nervous system lacks parts or has fewer parts of type myelinating Schwann cell , abnormal
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 ZFA:0000396 nervous system nervous system has fewer parts of type glioblast , abnormal
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 ZFA:0001094 whole organism whole organism decreased length , abnormal
whole organism dead , abnormal
whole organism curved , abnormal
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 ZFA:0001114 head head deformed , abnormal
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 ZFA:0009075 astrocyte astrocyte decreased amount , abnormal
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 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte absent , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000087646 runx1 / runt-related transcription factor 1 / Q01196*  / complex / reaction






 

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