ENSDARG00000004877


Danio rerio

Features
Gene ID: ENSDARG00000004877
  
Biological name :rock2b
  
Synonyms : rho-associated, coiled-coil containing protein kinase 2b / rock2b
  
Possible biological names infered from orthology : O75116 / Rho associated coiled-coil containing protein kinase 2 / ROCK2
  
Species: Danio rerio
  
Chr. number: 20
Strand: -1
Band:
Gene start: 33601046
Gene end: 33705044
  
Corresponding Affymetrix probe sets: Dr.15366.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000117860
Ensembl peptide - ENSDARP00000136393
Ensembl peptide - ENSDARP00000137413
NCBI entrez gene - 321070     See in Manteia.
RefSeq - NM_001093747
RefSeq Peptide - NP_001087216
swissprot - F1R417
swissprot - A0A0R4IQJ2
swissprot - Q5RH75
ZFIN ID - ZDB-GENE-060125-2
Ensembl - ENSDARG00000004877
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ROCK2ENSGALG00000016451Gallus gallus
 ROCK2ENSG00000134318Homo sapiens
 Rock2ENSMUSG00000020580Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
rock2a / rho-associated, coiled-coil containing protein kinase 2a / ROCK2* / O75116* / Rho associated coiled-coil containing protein kinase 2*ENSDARG0000001750065
rock1 / Rho-associated, coiled-coil containing protein kinase 1 / Q13464*ENSDARG0000005899353
rock2b / rho-associated, coiled-coil containing protein kinase 2b / ROCK2* / O75116* / Rho associated coiled-coil containing protein kinase 2*ENSDARG0000009643327
cdc42bpab / CDC42 binding protein kinase alpha (DMPK-like) b / Q9Y5S2* / Q3UU96* / Q5VT25* / Q7TT50* / CDC42BPA* / CDC42BPB* / CDC42 binding protein kinase beta* / CDC42 binding protein kin...ENSDARG0000001646426
cdc42bpb / CDC42 binding protein kinase beta (DMPK-like)ENSDARG0000001938326
cdc42bpaa / CDC42 binding protein kinase alpha (DMPK-like) a / Q9Y5S2* / Q3UU96* / Q5VT25* / Q7TT50* / CDC42BPA* / CDC42BPB* / CDC42 binding protein kinase beta* / CDC42 binding protein kin...ENSDARG0000010428326
cita / citron rho-interacting serine/threonine kinase aENSDARG0000008985622
DMPK / DM1 protein kinase / Q09013*ENSDARG0000007491412
si:dkey-65b13.9 / ROCK2* / O75116* / Rho associated coiled-coil containing protein kinase 2*ENSDARG0000010524912
lats1 / large tumor suppressor kinase 1 / O95835* / Q8BYR2* / Serine/threonine-protein kinase LATS1 *ENSDARG0000000375111
stk38b / serine/threonine kinase 38b / STK38* / Q15208* / Q91VJ4* / serine/threonine kinase 38* / Mus musculus serine/threonine kinase 38 (Stk38), transcript variant 2, mRNA.*ENSDARG0000001851611
stk38a / serine/threonine kinase 38a / STK38* / Q15208* / Q91VJ4* / serine/threonine kinase 38* / Mus musculus serine/threonine kinase 38 (Stk38), transcript variant 2, mRNA.*ENSDARG0000001997311
stk38l / serine/threonine kinase 38 like / Q7TSE6* / Q9Y2H1* / Mus musculus serine/threonine kinase 38 like (Stk38l), transcript variant 2, mRNA.*ENSDARG0000004548211
lats2 / large tumor suppressor kinase 2 / Q7TSJ6* / Q9NRM7* / Serine/threonine-protein kinase LATS2 *ENSDARG0000007886411
citb / citron rho-interacting serine/threonine kinase b / CIT* / O14578* / citron rho-interacting serine/threonine kinase*ENSDARG0000008882511


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR001849  Pleckstrin homology domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR015008  Rho binding domain
 IPR017441  Protein kinase, ATP binding site
 IPR020684  Rho-associated protein kinase 1/2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006939 smooth muscle contraction IEA
 biological_processGO:0007266 Rho protein signal transduction IEA
 biological_processGO:0010825 positive regulation of centrosome duplication IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0032956 regulation of actin cytoskeleton organization IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0060287 epithelial cilium movement involved in determination of left/right asymmetry IMP
 biological_processGO:0070121 Kupffer"s vesicle development IMP
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017048 Rho GTPase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
EPHB-mediated forward signaling
G alpha (12/13) signalling events
Sema4D induced cell migration and growth-cone collapse
VEGFA-VEGFR2 Pathway
RHO GTPases Activate ROCKs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000001 Kupffer s vesicle Kupffers vesicle decreased functionality , abnormal
Kupffers vesicle cilium spatial pattern , abnormal
Kupffers vesicle cilium symmetry , abnormal
Kupffers vesicle portion of organism substance decreased fluid flow , abnormal
Kupffers vesicle portion of organism substance circling direction , abnormal
Kupffers vesicle cell shape , abnormal
Kupffers vesicle cell cellular quality , abnormal
Kupffers vesicle cell structure , abnormal
Show

 ZFA:0000121 lateral plate mesoderm lateral plate mesoderm symmetry , abnormal
lateral plate mesoderm bilateral symmetry , abnormal
Show

 ZFA:0000123 liver liver inverted , abnormal
liver symmetry , abnormal
Show

 ZFA:0000140 pancreas pancreas inverted , abnormal
pancreas symmetry , abnormal
Show

 ZFA:0000360 heart tube heart tube inverted , abnormal
heart tube centered , abnormal
Show

 ZFA:0009000 cell cell apical side increased width , abnormal
cell apical surface increased size , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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