ENSGALG00000016451


Gallus gallus

Features
Gene ID: ENSGALG00000016451
  
Biological name :ROCK2
  
Synonyms : Rho associated coiled-coil containing protein kinase 2 / ROCK2
  
Possible biological names infered from orthology : O75116
  
Species: Gallus gallus
  
Chr. number: 3
Strand: -1
Band:
Gene start: 97626764
Gene end: 97719380
  
Corresponding Affymetrix probe sets: Gga.17943.1.S1_at (Chicken Array)   Gga.3500.1.S1_at (Chicken Array)   GgaAffx.10528.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000044656
Ensembl peptide - ENSGALP00000026490
NCBI entrez gene - 374182     See in Manteia.
RefSeq - XM_015276087
RefSeq - XM_015276085
RefSeq - XM_015276086
swissprot - F1NK88
swissprot - A0A1D5NWB8
Ensembl - ENSGALG00000016451
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rock2aENSDARG00000017500Danio rerio
 rock2bENSDARG00000096433Danio rerio
 rock2bENSDARG00000004877Danio rerio
 si:dkey-65b13.9ENSDARG00000105249Danio rerio
 ROCK2ENSG00000134318Homo sapiens
 Rock2ENSMUSG00000020580Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ROCK1 / Rho associated coiled-coil containing protein kinase 1 / P70335* / Q13464* / Rho-associated protein kinase 1 *ENSGALG0000001492265
CDC42BPA / CDC42 binding protein kinase alpha / Q3UU96* / Q5VT25* / Serine/threonine-protein kinase MRCK alpha *ENSGALG0000000915826
CDC42BPB / CDC42 binding protein kinase beta / Q7TT50* / Q9Y5S2*ENSGALG0000001143226
CIT / citron rho-interacting serine/threonine kinase / O14578*ENSGALG0000000735424
LATS1 / large tumor suppressor kinase 1 / O95835* / Q8BYR2* / Serine/threonine-protein kinase LATS1 *ENSGALG0000001238612
STK38 / serine/threonine kinase 38 / Q15208* / Q91VJ4* / Mus musculus serine/threonine kinase 38 (Stk38), transcript variant 2, mRNA.*ENSGALG0000000052311
STK38L / serine/threonine kinase 38 like / Q7TSE6* / Q9Y2H1* / Mus musculus serine/threonine kinase 38 like (Stk38l), transcript variant 2, mRNA.*ENSGALG0000001409411


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR001849  Pleckstrin homology domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR015008  Rho binding domain
 IPR017441  Protein kinase, ATP binding site
 IPR020684  Rho-associated protein kinase 1/2
 IPR029878  Rho-associated protein kinase 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006939 smooth muscle contraction IEA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0007266 Rho protein signal transduction IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010825 positive regulation of centrosome duplication IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IEA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0030866 cortical actin cytoskeleton organization IEA
 biological_processGO:0032956 regulation of actin cytoskeleton organization IEA
 biological_processGO:0035509 negative regulation of myosin-light-chain-phosphatase activity IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0039694 viral RNA genome replication IEA
 biological_processGO:0045616 regulation of keratinocyte differentiation IEA
 biological_processGO:0051298 centrosome duplication IEA
 biological_processGO:0071394 cellular response to testosterone stimulus IEA
 biological_processGO:0072659 protein localization to plasma membrane IEA
 biological_processGO:0150033 negative regulation of protein localization to lysosome IEA
 biological_processGO:1902004 positive regulation of amyloid-beta formation IEA
 biological_processGO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process IEA
 biological_processGO:1902966 positive regulation of protein localization to early endosome IEA
 biological_processGO:1902993 positive regulation of amyloid precursor protein catabolic process IEA
 biological_processGO:1903140 regulation of establishment of endothelial barrier IEA
 biological_processGO:1903347 negative regulation of bicellular tight junction assembly IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017048 Rho GTPase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0072518 Rho-dependent protein serine/threonine kinase activity IEA


Pathways (from Reactome)
Pathway description
EPHB-mediated forward signaling
G alpha (12/13) signalling events
Sema4D induced cell migration and growth-cone collapse
VEGFA-VEGFR2 Pathway
RHO GTPases Activate ROCKs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001569 RHOC / Q9PSX7 / Rho-related GTP-binding protein RhoC / Q62159* / P08134* / ras homolog family member C*  / complex / reaction
 ENSGALG00000016485 RHOB / ras homolog family member B / P62745* / P62746*  / complex / reaction
 ENSGALG00000003855 SRC / P00523 / Proto-oncogene tyrosine-protein kinase Src / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction
 ENSGALG00000013907 KDR / vascular endothelial growth factor receptor 2 precursor / P35968* / kinase insert domain receptor*  / reaction
 ENSGALG00000010290 VEGFA / P67964 / Vascular endothelial growth factor A / P15692* / Q00731*  / reaction
 ENSGALG00000031741 PTK2 / Q00944 / Focal adhesion kinase 1 / P34152* / Q05397* / protein tyrosine kinase 2* / PTK2 protein tyrosine kinase 2*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr