ENSGALG00000014922


Gallus gallus

Features
Gene ID: ENSGALG00000014922
  
Biological name :ROCK1
  
Synonyms : Rho associated coiled-coil containing protein kinase 1 / ROCK1
  
Possible biological names infered from orthology : P70335 / Q13464 / Rho-associated protein kinase 1
  
Species: Gallus gallus
  
Chr. number: 2
Strand: -1
Band:
Gene start: 102467970
Gene end: 102544390
  
Corresponding Affymetrix probe sets: Gga.1353.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000053193
Ensembl peptide - ENSGALP00000036056
NCBI entrez gene - 373970     See in Manteia.
RefSeq - XM_015277932
RefSeq - NM_001199448
RefSeq - XM_015277931
RefSeq Peptide - NP_001186377
swissprot - F1NRH6
swissprot - A0A1D5PK41
Ensembl - ENSGALG00000014922
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rock1ENSDARG00000058993Danio rerio
 ROCK1ENSG00000067900Homo sapiens
 Rock1ENSMUSG00000024290Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ROCK2 / Rho associated coiled-coil containing protein kinase 2 / O75116*ENSGALG0000001645165
CDC42BPA / CDC42 binding protein kinase alpha / Q3UU96* / Q5VT25* / Serine/threonine-protein kinase MRCK alpha *ENSGALG0000000915827
CDC42BPB / CDC42 binding protein kinase beta / Q7TT50* / Q9Y5S2*ENSGALG0000001143226
CIT / citron rho-interacting serine/threonine kinase / O14578*ENSGALG0000000735424
LATS1 / large tumor suppressor kinase 1 / O95835* / Q8BYR2* / Serine/threonine-protein kinase LATS1 *ENSGALG0000001238612
STK38 / serine/threonine kinase 38 / Q15208* / Q91VJ4* / Mus musculus serine/threonine kinase 38 (Stk38), transcript variant 2, mRNA.*ENSGALG0000000052311
STK38L / serine/threonine kinase 38 like / Q7TSE6* / Q9Y2H1* / Mus musculus serine/threonine kinase 38 like (Stk38l), transcript variant 2, mRNA.*ENSGALG0000001409411


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR001849  Pleckstrin homology domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR015008  Rho binding domain
 IPR017441  Protein kinase, ATP binding site
 IPR020684  Rho-associated protein kinase 1/2
 IPR029876  Rho-associated protein kinase 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003383 apical constriction IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007159 leukocyte cell-cell adhesion IEA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0007266 Rho protein signal transduction IEA
 biological_processGO:0010508 positive regulation of autophagy IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0022614 membrane to membrane docking IEA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0030866 cortical actin cytoskeleton organization IEA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0032060 bleb assembly IEA
 biological_processGO:0032091 negative regulation of protein binding IEA
 biological_processGO:0032956 regulation of actin cytoskeleton organization IEA
 biological_processGO:0032970 regulation of actin filament-based process IEA
 biological_processGO:0035509 negative regulation of myosin-light-chain-phosphatase activity IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0045616 regulation of keratinocyte differentiation IEA
 biological_processGO:0045664 regulation of neuron differentiation IEA
 biological_processGO:0050900 leukocyte migration IEA
 biological_processGO:0050901 leukocyte tethering or rolling IEA
 biological_processGO:0051451 myoblast migration IEA
 biological_processGO:0051492 regulation of stress fiber assembly IEA
 biological_processGO:0051493 regulation of cytoskeleton organization IEA
 biological_processGO:0051894 positive regulation of focal adhesion assembly IEA
 biological_processGO:0072659 protein localization to plasma membrane IEA
 biological_processGO:0140058 neuron projection arborization IEA
 biological_processGO:1900223 positive regulation of amyloid-beta clearance IEA
 biological_processGO:1900242 regulation of synaptic vesicle endocytosis IEA
 biological_processGO:1902430 negative regulation of amyloid-beta formation IEA
 biological_processGO:1902992 negative regulation of amyloid precursor protein catabolic process IEA
 biological_processGO:1903140 regulation of establishment of endothelial barrier IEA
 biological_processGO:1903347 negative regulation of bicellular tight junction assembly IEA
 biological_processGO:2000114 regulation of establishment of cell polarity IEA
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0106003 amyloid-beta complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017048 Rho GTPase binding IEA
 molecular_functionGO:0017049 GTP-Rho binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Apoptotic cleavage of cellular proteins
EPHB-mediated forward signaling
G alpha (12/13) signalling events
Sema4D induced cell migration and growth-cone collapse
VEGFA-VEGFR2 Pathway
RHO GTPases Activate ROCKs
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001569 RHOC / Q9PSX7 / Rho-related GTP-binding protein RhoC / Q62159* / P08134* / ras homolog family member C*  / complex / reaction
 ENSGALG00000016485 RHOB / ras homolog family member B / P62745* / P62746*  / complex / reaction
 ENSGALG00000010638 CASP3 / caspase 3 / P42574* / P70677* / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12*  / reaction
 ENSGALG00000003855 SRC / P00523 / Proto-oncogene tyrosine-protein kinase Src / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction
 ENSGALG00000013907 KDR / vascular endothelial growth factor receptor 2 precursor / P35968* / kinase insert domain receptor*  / reaction
 ENSGALG00000010290 VEGFA / P67964 / Vascular endothelial growth factor A / P15692* / Q00731*  / reaction
 ENSGALG00000031741 PTK2 / Q00944 / Focal adhesion kinase 1 / P34152* / Q05397* / protein tyrosine kinase 2* / PTK2 protein tyrosine kinase 2*  / reaction






 

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