ENSGALG00000010638


Gallus gallus

Features
Gene ID: ENSGALG00000010638
  
Biological name :CASP3
  
Synonyms : CASP3 / caspase 3
  
Possible biological names infered from orthology : Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12 / P42574 / P70677
  
Species: Gallus gallus
  
Chr. number: 4
Strand: 1
Band:
Gene start: 39778505
Gene end: 39789210
  
Corresponding Affymetrix probe sets: Gga.4346.1.S1_at (Chicken Array)   Gga.4346.1.S2_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000017288
NCBI entrez gene - 395476     See in Manteia.
RefSeq - XM_015276122
RefSeq - NM_204725
RefSeq - XM_015276123
RefSeq Peptide - NP_990056
swissprot - O93417
Ensembl - ENSGALG00000010638
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 casp3aENSDARG00000017905Danio rerio
 casp3bENSDARG00000055045Danio rerio
 CASP3ENSG00000164305Homo sapiens
 Casp3ENSMUSG00000031628Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CASP7 / caspase 7 / P55210* / P97864* / Caspase-7 Caspase-7 subunit p20 Caspase-7 subunit p11*ENSGALG0000000893353
CASP6 / caspase-6 / O08738* / P55212* / Caspase-6 Caspase-6 subunit p18 Caspase-6 subunit p11*ENSGALG0000001218635
CASP8 / caspase-8 / O89110* / Q14790* / Caspase-8 Caspase-8 subunit p18 Caspase-8 subunit p10*ENSGALG0000000835534
CASP9 / caspase 9 / P55211* / Q8C3Q9* / Mus musculus caspase 9 (Casp9), transcript variant 3, mRNA.*ENSGALG0000000136633
CASP10 / caspase 10 / Q92851*ENSGALG0000004649433
CASP18ENSGALG0000000834631
CASP2 / caspase-2 / P29594* / P42575* / Caspase-2 Caspase-2 subunit p18 Caspase-2 subunit p13 Caspase-2 subunit p12*ENSGALG0000001469829


Protein motifs (from Interpro)
Interpro ID Name
 IPR001309  Peptidase C14, p20 domain
 IPR002138  Peptidase C14, caspase non-catalytic subunit p10
 IPR015917  Peptidase C14A, caspase catalytic domain
 IPR016129  Peptidase family C14A, His active site
 IPR029030  Caspase-like domain superfamily
 IPR033139  Peptidase family C14A, cysteine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001782 B cell homeostasis IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007605 sensory perception of sound IEA
 biological_processGO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress IEA
 biological_processGO:0009411 response to UV IEA
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0016485 protein processing IEA
 biological_processGO:0030182 neuron differentiation IBA
 biological_processGO:0030216 keratinocyte differentiation IEA
 biological_processGO:0030218 erythrocyte differentiation IEA
 biological_processGO:0030889 negative regulation of B cell proliferation IEA
 biological_processGO:0034349 glial cell apoptotic process IEA
 biological_processGO:0043029 T cell homeostasis IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045165 cell fate commitment IEA
 biological_processGO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity IEA
 biological_processGO:0045786 negative regulation of cell cycle IEA
 biological_processGO:0046007 negative regulation of activated T cell proliferation IEA
 biological_processGO:0048011 neurotrophin TRK receptor signaling pathway IEA
 biological_processGO:0051402 neuron apoptotic process IEA
 biological_processGO:0071310 cellular response to organic substance IEA
 biological_processGO:0072734 cellular response to staurosporine IEA
 biological_processGO:0097194 execution phase of apoptosis IEA
 biological_processGO:0098586 cellular response to virus IMP
 cellular_componentGO:0005623 cell IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0004190 aspartic-type endopeptidase activity IEA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IEA
 molecular_functionGO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0097153 cysteine-type endopeptidase activity involved in apoptotic process IEA
 molecular_functionGO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis IEA


Pathways (from Reactome)
Pathway description
Activation of caspases through apoptosome-mediated cleavage
Apoptotic cleavage of cellular proteins
Signaling by Hippo
Activation of DNA fragmentation factor
Caspase-mediated cleavage of cytoskeletal proteins
Apoptotic cleavage of cell adhesion proteins
Other interleukin signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001366 CASP9 / caspase 9 / P55211* / Q8C3Q9* / Mus musculus caspase 9 (Casp9), transcript variant 3, mRNA.*  / reaction
 ENSGALG00000000220 APC / APC, WNT signaling pathway regulator / P25054*  / reaction
 ENSGALG00000000608 CDH1 / cadherin 1 / P12830*  / reaction
 ENSGALG00000001446 GSN / gelsolin precursor / P06396* / P13020* / gelsolin*  / reaction
 ENSGALG00000002016 PRKCD / protein kinase C delta type / P28867* / Q05655* / protein kinase C delta*  / reaction
 ENSGALG00000003655 GAS2 / growth arrest specific 2 / O43903* / P11862* / Mus musculus growth arrest specific 2 (Gas2), transcript variant 2, mRNA.*  / reaction
 ENSGALG00000004098 STK4 / serine/threonine-protein kinase 4 / Q13043* / Q9JI11* / serine/threonine kinase 4*  / reaction
 ENSGALG00000002820 DFFA / DNA fragmentation factor subunit alpha / O00273* / O54786*  / reaction
 ENSGALG00000006049 STK26 / serine/threonine kinase 26 / Q99JT2* / Q9P289*  / reaction
 ENSGALG00000006388 IL16 / interleukin 16 / O54824* / Q14005* / Pro-interleukin-16 Interleukin-16*  / reaction
 ENSGALG00000015142 DSG2 / desmoglein 2 / O55111* / Q14126*  / reaction
 ENSGALG00000016557 BMX / BMX non-receptor tyrosine kinase / P51813* / P97504* / Cytoplasmic tyrosine-protein kinase BMX *  / reaction
 ENSGALG00000000299 PKP1 / plakophilin 1 / P97350* / Q13835*  / reaction
 ENSGALG00000015109 TJP2 / tight junction protein ZO-2 / Q9Z0U1* / Q9UDY2* / AL358113.1* / tight junction protein 2*  / reaction
 ENSGALG00000017186 BIRC2 / BIRC3* / Q62210* / Q13489* / Q13490* / baculoviral IAP repeat containing 2* / baculoviral IAP repeat containing 3* / Baculoviral IAP repeat-containing protein 2 *  / reaction
 ENSGALG00000015664 ADD1 / adducin 1 / P35611* / Q9QYC0* / Mus musculus adducin 1 (alpha) (Add1), transcript variant 5, mRNA.*  / reaction
 ENSGALG00000010638 CASP3 / caspase 3 / P42574* / P70677* / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12*  / complex
 ENSGALG00000016885 STK24 / serine/threonine kinase 24 / Q99KH8* / Q9Y6E0*  / reaction
 ENSGALG00000042552 TJP1 / tight junction protein 1 / P39447* / Q07157*  / reaction
 ENSGALG00000014922 ROCK1 / Rho associated coiled-coil containing protein kinase 1 / P70335* / Q13464* / Rho-associated protein kinase 1 *  / reaction
 ENSGALG00000036295 DFFB / DNA fragmentation factor subunit beta / O54788* / O76075*  / reaction
 ENSGALG00000034970 PRKCQ / protein kinase C theta / Q02111* / Q04759*  / reaction






 

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