ENSGALG00000008933


Gallus gallus

Features
Gene ID: ENSGALG00000008933
  
Biological name :CASP7
  
Synonyms : CASP7 / caspase 7
  
Possible biological names infered from orthology : Caspase-7 Caspase-7 subunit p20 Caspase-7 subunit p11 / P55210 / P97864
  
Species: Gallus gallus
  
Chr. number: 6
Strand: 1
Band:
Gene start: 27520205
Gene end: 27538328
  
Corresponding Affymetrix probe sets: GgaAffx.5618.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000014503
NCBI entrez gene - 423901     See in Manteia.
RefSeq - XM_421764
swissprot - F1NV61
Ensembl - ENSGALG00000008933
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 casp7ENSDARG00000091836Danio rerio
 CASP7ENSG00000165806Homo sapiens
 Casp7ENSMUSG00000025076Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CASP3 / caspase 3 / P42574* / P70677* / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12*ENSGALG0000001063849
CASP6 / caspase-6 / O08738* / P55212* / Caspase-6 Caspase-6 subunit p18 Caspase-6 subunit p11*ENSGALG0000001218635
CASP8 / caspase-8 / O89110* / Q14790* / Caspase-8 Caspase-8 subunit p18 Caspase-8 subunit p10*ENSGALG0000000835534
CASP9 / caspase 9 / P55211* / Q8C3Q9* / Mus musculus caspase 9 (Casp9), transcript variant 3, mRNA.*ENSGALG0000000136632
CASP10 / caspase 10 / Q92851*ENSGALG0000004649430
CASP18ENSGALG0000000834629
CASP2 / caspase-2 / P29594* / P42575* / Caspase-2 Caspase-2 subunit p18 Caspase-2 subunit p13 Caspase-2 subunit p12*ENSGALG0000001469826


Protein motifs (from Interpro)
Interpro ID Name
 IPR001309  Peptidase C14, p20 domain
 IPR002138  Peptidase C14, caspase non-catalytic subunit p10
 IPR015917  Peptidase C14A, caspase catalytic domain
 IPR016129  Peptidase family C14A, His active site
 IPR029030  Caspase-like domain superfamily
 IPR033139  Peptidase family C14A, cysteine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0009411 response to UV IEA
 biological_processGO:0016485 protein processing IEA
 biological_processGO:0051402 neuron apoptotic process IEA
 biological_processGO:0097194 execution phase of apoptosis IEA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004190 aspartic-type endopeptidase activity IEA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0097153 cysteine-type endopeptidase activity involved in apoptotic process IEA
 molecular_functionGO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis IBA


Pathways (from Reactome)
Pathway description
Activation of caspases through apoptosome-mediated cleavage
SMAC binds to IAPs
SMAC-mediated dissociation of IAP:caspase complexes
Apoptotic cleavage of cellular proteins
Caspase-mediated cleavage of cytoskeletal proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001366 CASP9 / caspase 9 / P55211* / Q8C3Q9* / Mus musculus caspase 9 (Casp9), transcript variant 3, mRNA.*  / reaction
 ENSGALG00000003655 GAS2 / growth arrest specific 2 / O43903* / P11862* / Mus musculus growth arrest specific 2 (Gas2), transcript variant 2, mRNA.*  / reaction
 ENSGALG00000004412 DIABLO* / Q9JIQ3* / Q9NR28* / Diablo homolog, mitochondrial * / diablo IAP-binding mitochondrial protein*  / complex / reaction
 ENSGALG00000008491 XIAP / BIRC8* / P98170* / Q60989* / Q96P09* / X-linked inhibitor of apoptosis* / baculoviral IAP repeat containing 8*  / complex
 ENSGALG00000008933 CASP7 / caspase 7 / P55210* / P97864* / Caspase-7 Caspase-7 subunit p20 Caspase-7 subunit p11*  / complex
 ENSGALG00000016885 STK24 / serine/threonine kinase 24 / Q99KH8* / Q9Y6E0*  / reaction
 ENSGALG00000031741 PTK2 / Q00944 / Focal adhesion kinase 1 / P34152* / Q05397* / protein tyrosine kinase 2* / PTK2 protein tyrosine kinase 2*  / reaction






 

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