ENSDARG00000105249


Danio rerio
proteinsi:dkey-65b13.9kinasedomainkinase-likesuperfamilyphosphorylationactivityatpbindingephb-mediatedforwardsignalinggalphasignallingeventssemadinducedcellmigrationgrowth-conecollapsevegfa-vegfrpathwayrhogtpasesactivaterocks

Features
Gene ID: ENSDARG00000105249
  
Biological name :si:dkey-65b13.9
  
Synonyms : si:dkey-65b13.9
  
Possible biological names infered from orthology : O75116 / Rho associated coiled-coil containing protein kinase 2 / ROCK2
  
Species: Danio rerio
  
Chr. number: 20
Strand: -1
Band:
Gene start: 33564425
Gene end: 33566640
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000130960
swissprot - A0A0R4ID79
ZFIN ID - ZDB-GENE-041014-335
Ensembl - ENSDARG00000105249
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ROCK2ENSGALG00000016451Gallus gallus
 ROCK2ENSG00000134318Homo sapiens
 Rock2ENSMUSG00000020580Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
rock2b / rho-associated, coiled-coil containing protein kinase 2b / ROCK2* / O75116* / Rho associated coiled-coil containing protein kinase 2*ENSDARG0000000487796
rock2a / rho-associated, coiled-coil containing protein kinase 2a / ROCK2* / O75116* / Rho associated coiled-coil containing protein kinase 2*ENSDARG0000001750080
rock1 / Rho-associated, coiled-coil containing protein kinase 1 / Q13464*ENSDARG0000005899377
cdc42bpb / CDC42 binding protein kinase beta (DMPK-like)ENSDARG0000001938359
cdc42bpab / CDC42 binding protein kinase alpha (DMPK-like) b / Q9Y5S2* / Q3UU96* / Q5VT25* / Q7TT50* / CDC42BPA* / CDC42BPB* / CDC42 binding protein kinase beta* / CDC42 binding protein kin...ENSDARG0000001646458
cdc42bpaa / CDC42 binding protein kinase alpha (DMPK-like) a / Q9Y5S2* / Q3UU96* / Q5VT25* / Q7TT50* / CDC42BPA* / CDC42BPB* / CDC42 binding protein kinase beta* / CDC42 binding protein kin...ENSDARG0000010428357
stk38b / serine/threonine kinase 38b / STK38* / Q15208* / Q91VJ4* / serine/threonine kinase 38* / Mus musculus serine/threonine kinase 38 (Stk38), transcript variant 2, mRNA.*ENSDARG0000001851651
stk38a / serine/threonine kinase 38a / STK38* / Q15208* / Q91VJ4* / serine/threonine kinase 38* / Mus musculus serine/threonine kinase 38 (Stk38), transcript variant 2, mRNA.*ENSDARG0000001997351
stk38l / serine/threonine kinase 38 like / Q7TSE6* / Q9Y2H1* / Mus musculus serine/threonine kinase 38 like (Stk38l), transcript variant 2, mRNA.*ENSDARG0000004548251
DMPK / DM1 protein kinase / Q09013*ENSDARG0000007491450
lats1 / large tumor suppressor kinase 1 / O95835* / Q8BYR2* / Serine/threonine-protein kinase LATS1 *ENSDARG0000000375145
lats2 / large tumor suppressor kinase 2 / Q7TSJ6* / Q9NRM7* / Serine/threonine-protein kinase LATS2 *ENSDARG0000007886445
cita / citron rho-interacting serine/threonine kinase aENSDARG0000008985640
citb / citron rho-interacting serine/threonine kinase b / CIT* / O14578* / citron rho-interacting serine/threonine kinase*ENSDARG000000888250
rock2b / rho-associated, coiled-coil containing protein kinase 2b / ROCK2* / O75116* / Rho associated coiled-coil containing protein kinase 2*ENSDARG000000964330


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily


Gene Ontology (GO)
nitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processnitrogen compound metabolic processcellular metabolic processcellular metabolic processprimary metabolic processprimary metabolic processorganic substance metabolic processorganic substance metabolic process
catalytic activity, acting on a proteintransferase activityion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingdrug bindingcatalytic activity, acting on a proteintransferase activityion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingdrug bindingcatalytic activity, acting on a proteintransferase activityion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingdrug bindingcatalytic activity, acting on a proteintransferase activityion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingdrug bindingcatalytic activity, acting on a proteintransferase activityion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingdrug bindingcatalytic activity, acting on a proteintransferase activityion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingdrug bindingcatalytic activity, acting on a proteintransferase activityion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingdrug bindingcatalytic activity, acting on a proteintransferase activityion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingdrug bindingcatalytic activity, acting on a proteintransferase activityion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingdrug bindingcatalytic activity, acting on a proteintransferase activityion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingdrug bindingcatalytic activitcatalytic activity, acting on a proteintransferase activtransferase activityion bindingion bindingcarbohydrate dericarbohydrate derivative bindingorganic cyclic coorganic cyclic compound bindingheterocyclic compheterocyclic compound bindingsmall molecule bismall molecule bindingdrug bindingdrug binding
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
EPHB-mediated forward signaling
G alpha (12/13) signalling events
Sema4D induced cell migration and growth-cone collapse
VEGFA-VEGFR2 Pathway
RHO GTPases Activate ROCKs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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