ENSDARG00000006169


Danio rerio

Features
Gene ID: ENSDARG00000006169
  
Biological name :lrrk2
  
Synonyms : leucine-rich repeat kinase 2 / lrrk2
  
Possible biological names infered from orthology : Leucine-rich repeat serine/threonine-protein kinase 2 / Q5S006 / Q5S007
  
Species: Danio rerio
  
Chr. number: 25
Strand: -1
Band:
Gene start: 35603107
Gene end: 35664817
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000123741
NCBI entrez gene - 559366     See in Manteia.
RefSeq - NM_001201456
RefSeq Peptide - NP_001188385
swissprot - F8W598
ZFIN ID - ZDB-GENE-071218-6
Ensembl - ENSDARG00000006169
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LRRK2ENSGALG00000007161Gallus gallus
 LRRK2ENSG00000188906Homo sapiens
 Lrrk2ENSMUSG00000036273Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
lrrk1 / leucine-rich repeat kinase 1 / Q38SD2* / Q3UHC2* / Leucine-rich repeat serine/threonine-protein kinase 1 *ENSDARG0000000739812
prkd1 / protein kinase D1 / Q15139* / Q62101*ENSDARG000000759497
prkd3 / protein kinase D3 / O94806* / Q8K1Y2*ENSDARG000000799677
zgc:175248ENSDARG000001041535
prkd2 / protein kinase D2 / Q8BZ03* / Q9BZL6*ENSDARG000001046764
FO704748.1 / PRKD2* / Q9BZL6* / protein kinase D2*ENSDARG000000870181


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011989  Armadillo-like helical
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016024  Armadillo-type fold
 IPR017441  Protein kinase, ATP binding site
 IPR017986  WD40-repeat-containing domain
 IPR020683  Ankyrin repeat-containing domain
 IPR020859  Roc domain
 IPR025875  Leucine rich repeat 4
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR032171  C-terminal of Roc (COR) domain
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
PTK6 promotes HIF1A stabilization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain has fewer parts of type dopaminergic neuron , abnormal
brain decreased amount , abnormal
brain has fewer parts of type neuron , abnormal
Show

 ZFA:0000029 hindbrain hindbrain increased amount , abnormal
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 ZFA:0000035 lens lens edematous , abnormal
Show

 ZFA:0000051 otic vesicle otic vesicle edematous , abnormal
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 ZFA:0000059 postoptic commissure postoptic commissure increased amount , abnormal
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 ZFA:0000075 spinal cord spinal cord has fewer parts of type neuron , abnormal
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 ZFA:0000101 diencephalon diencephalon dopaminergic neuron irregular spatial pattern , abnormal
diencephalon dopaminergic neuron decreased amount , abnormal
diencephalon increased amount , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
eye malformed , abnormal
eye edematous , abnormal
Show

 ZFA:0000114 heart heart morphology , abnormal
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 ZFA:0000128 midbrain midbrain neuron decreased amount , abnormal
midbrain increased amount , abnormal
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 ZFA:0000150 pronephric duct pronephric duct apicolateral plasma membrane mislocalised , abnormal
pronephric duct kidney epithelium development process quality , abnormal
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 ZFA:0000445 optic tectum optic tectum axon decreased amount , abnormal
optic tectum neuron decreased amount , abnormal
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 ZFA:0001094 whole organism whole organism increased amount , abnormal
whole organism decreased amount , abnormal
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 ZFA:0001114 head head morphology , abnormal
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 ZFA:0001117 post-vent region post-vent region bent , abnormal
post-vent region cell death increased occurrence , abnormal
Show

 ZFA:0001284 optic fissure optic fissure open , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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