Manteia

ENSDARG00000006865

Danio rerio

Features

Gene ID:	ENSDARG00000006865

Biological name :	glra4a

Synonyms :	glra4a / glycine receptor, alpha 4a

Possible biological names infered from orthology :	GLRA4 / glycine receptor alpha 4 / Glycine receptor subunit alpha-4 / Q5JXX5 / Q61603

Species:	Danio rerio

Chr. number:	14
Strand:	-1
Band:
Gene start:	39002116
Gene end:	39074539

Corresponding Affymetrix probe sets:	Dr.10675.1.S1_at (Zebrafish Array) Dr.16085.1.S1_at (Zebrafish Array) NM_131782_at (Zebrafish Genome Array with custom cdf files)

Cross references:	Ensembl peptide - ENSDARP00000030826 Ensembl peptide - ENSDARP00000027157 NCBI entrez gene - 83413 See in Manteia. RefSeq - XM_005169598 RefSeq - NM_131782 RefSeq Peptide - NP_571857 swissprot - F1RDZ6 swissprot - F1QJA0 ZFIN ID - ZDB-GENE-010410-3 Ensembl - ENSDARG00000006865

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
GLRA4	ENSGALG00000004936	Gallus gallus
GLRA4	ENSG00000188828	Homo sapiens
Glra4	ENSMUSG00000018595	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
glra4b / glycine receptor, alpha 4b / GLRA4* / Q5JXX5* / Q61603* / glycine receptor alpha 4* / Glycine receptor subunit alpha-4 *	ENSDARG00000058103	79
glra2 / si:ch211-12n8.3	ENSDARG00000075012	76
glra3 / glycine receptor, alpha 3	ENSDARG00000011066	74
glra1 / O93430 / glycine receptor, alpha 1 / Q64018* / P23415* / Glycine receptor subunit alpha-1 *	ENSDARG00000012019	73
glrbb / glycine receptor, beta b / GLRB* / P48167* / P48168* / glycine receptor beta* / Glycine receptor subunit beta *	ENSDARG00000052769	48
glrba / glycine receptor, beta a / GLRB* / P48167* / P48168* / glycine receptor beta* / Glycine receptor subunit beta *	ENSDARG00000052782	46
gabrb4 / gamma-aminobutyric acid (GABA) A receptor, beta 4 / GABRQ* / Q9UN88* / Q9JLF1* / Gamma-aminobutyric acid receptor subunit theta * / gamma-aminobutyric acid type A receptor theta subunit*	ENSDARG00000099096	36
gabrb1 / gamma-aminobutyric acid (GABA) A receptor, beta 1 / P18505* / P50571* / Gamma-aminobutyric acid receptor subunit beta-1 * / gamma-aminobutyric acid type A receptor beta1 subunit*	ENSDARG00000076127	35
gabrb3 / gamma-aminobutyric acid (GABA) A receptor, beta 3	ENSDARG00000023771	34
gabrd / gamma-aminobutyric acid (GABA) A receptor, delta / O14764* / P22933* / Gamma-aminobutyric acid receptor subunit delta * / gamma-aminobutyric acid type A receptor delta subunit*	ENSDARG00000059763	33
GABRB2 (1 of many) / gamma-aminobutyric acid type A receptor beta2 subunit / GABRB2* / P47870*	ENSDARG00000100032	33
gabrp / gamma-aminobutyric acid (GABA) A receptor, pi	ENSDARG00000020901	32
AL929217.1 / GABRP* / O00591* / gamma-aminobutyric acid type A receptor pi subunit*	ENSDARG00000059891	32
gabrz / gamma-aminobutyric acid (GABA) A receptor, zeta	ENSDARG00000094512	32
gabrr2b / gamma-aminobutyric acid (GABA) A receptor, rho 2b / P56476* / GABRR2* / P28476* / Gamma-aminobutyric acid receptor subunit rho-2 * / gamma-aminobutyric acid type A receptor rho2 subunit*	ENSDARG00000014057	31
gabrr1 / gamma-aminobutyric acid (GABA) A receptor, rho 1 / P24046* / P56475* / Gamma-aminobutyric acid receptor subunit rho-1 * / gamma-aminobutyric acid type A receptor rho1 subunit*	ENSDARG00000043902	31
FO704905.1 / GABRR1* / P24046* / gamma-aminobutyric acid type A receptor rho1 subunit*	ENSDARG00000098081	31
gabrr3a / gamma-aminobutyric acid (GABA) A receptor, rho 3a / A8MPY1* / GABRR3* / gamma-aminobutyric acid type A receptor rho3 subunit (gene/pseudogene)*	ENSDARG00000027153	30
gabrr3b / gamma-aminobutyric acid (GABA) A receptor, rho 3b / A8MPY1* / GABRR3* / gamma-aminobutyric acid type A receptor rho3 subunit (gene/pseudogene)*	ENSDARG00000030750	30
gabrb2 / gamma-aminobutyric acid (GABA) A receptor, beta 2 / P47870* / P63137* / Gamma-aminobutyric acid receptor subunit beta-2 * / gamma-aminobutyric acid type A receptor beta2 subunit*	ENSDARG00000079586	29

Protein motifs (from Interpro)

Interpro ID	Name
IPR006028	Gamma-aminobutyric acid A receptor/Glycine receptor alpha
IPR006029	Neurotransmitter-gated ion-channel transmembrane domain
IPR006201	Neurotransmitter-gated ion-channel
IPR006202	Neurotransmitter-gated ion-channel ligand-binding domain
IPR008127	Glycine receptor alpha
IPR008129	Glycine receptor alpha2
IPR018000	Neurotransmitter-gated ion-channel, conserved site

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006811	ion transport	IEA
biological_process	GO:0006821	chloride transport	IDA
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0007218	neuropeptide signaling pathway	IBA
biological_process	GO:0007417	central nervous system development	IMP
biological_process	GO:0034220	ion transmembrane transport	IEA
biological_process	GO:0043200	response to amino acid	IDA
biological_process	GO:0045664	regulation of neuron differentiation	IMP
biological_process	GO:0060012	synaptic transmission, glycinergic	IBA
biological_process	GO:0060079	excitatory postsynaptic potential	IEA
biological_process	GO:1902476	chloride transmembrane transport	IEA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0005887	integral component of plasma membrane	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0045211	postsynaptic membrane	IEA
cellular_component	GO:0098794	postsynapse	IEA
molecular_function	GO:0004888	transmembrane signaling receptor activity	IEA
molecular_function	GO:0005216	ion channel activity	IEA
molecular_function	GO:0005230	extracellular ligand-gated ion channel activity	IEA
molecular_function	GO:0016594	glycine binding	IEA
molecular_function	GO:0016934	extracellularly glycine-gated chloride channel activity	IEA
molecular_function	GO:0022824	transmitter-gated ion channel activity	IEA

Pathways (from Reactome)

Pathway description

Neurotransmitter receptors and postsynaptic signal transmission

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
ZFA:0000075	spinal cord	spinal cord motor neuron decreased functionality , abnormal	Show
ZFA:0000778	spinal cord interneuron	spinal cord interneuron decreased amount , abnormal	Show
ZFA:0009019	neuronal stem cell	neuronal stem cell increased amount , abnormal neuronal stem cell decreased amount , abnormal	Show
ZFA:0009052	motor neuron	motor neuron decreased functionality , abnormal	Show

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr