ENSG00000188828


Homo sapiens
neurotransmitter-gatedion-channelchannelactivityGLRA4transmembraneionchloridemembranereceptordomaintransportglycinepostsynapticacidalphaligand-bindingsuperfamilysignalingtransmissionplasmaintegralcomponentcellgamma-aminobutyricconservedsiteneuropeptidepathwayresponseamino

Features
Gene ID: ENSG00000188828
  
Biological name :GLRA4
  
Synonyms : GLRA4 / glycine receptor alpha 4 / Q5JXX5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: -1
Band: q22.2
Gene start: 103707224
Gene end: 103728655
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSP00000361700
Ensembl peptide - ENSP00000412480
NCBI entrez gene - 441509     See in Manteia.
RefSeq - NM_001024452
RefSeq - NM_001172285
RefSeq Peptide - NP_001019623
RefSeq Peptide - NP_001165756
swissprot - Q5JXX5
swissprot - F8WCE1
Ensembl - ENSG00000188828
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 glra4aENSDARG00000006865Danio rerio
 glra4bENSDARG00000058103Danio rerio
 GLRA4ENSGALG00000004936Gallus gallus
 Glra4ENSMUSG00000018595Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GLRA2 / P23416 / glycine receptor alpha 2ENSG0000010195878
GLRA3 / O75311 / glycine receptor alpha 3ENSG0000014545175
GLRA1 / P23415 / glycine receptor alpha 1ENSG0000014588873
GLRB / P48167 / glycine receptor betaENSG0000010973846
GABRB2 / P47870 / gamma-aminobutyric acid type A receptor beta2 subunitENSG0000014586437
GABRB1 / P18505 / gamma-aminobutyric acid type A receptor beta1 subunitENSG0000016328837
GABRB3 / P28472 / gamma-aminobutyric acid type A receptor beta3 subunitENSG0000016620636
GABRD / O14764 / gamma-aminobutyric acid type A receptor delta subunitENSG0000018773035
GABRQ / Q9UN88 / gamma-aminobutyric acid type A receptor theta subunitENSG0000026808933
GABRR2 / P28476 / gamma-aminobutyric acid type A receptor rho2 subunitENSG0000011188632
GABRR1 / P24046 / gamma-aminobutyric acid type A receptor rho1 subunitENSG0000014627631
GABRP / O00591 / gamma-aminobutyric acid type A receptor pi subunitENSG0000009475530
A8MPY1 / GABRR3 / gamma-aminobutyric acid type A receptor rho3 subunit (gene/pseudogene)ENSG0000018318530


Protein motifs (from Interpro)
Interpro ID Name
 IPR006028  Gamma-aminobutyric acid A receptor/Glycine receptor alpha
 IPR006029  Neurotransmitter-gated ion-channel transmembrane domain
 IPR006201  Neurotransmitter-gated ion-channel
 IPR006202  Neurotransmitter-gated ion-channel ligand-binding domain
 IPR008127  Glycine receptor alpha
 IPR018000  Neurotransmitter-gated ion-channel, conserved site
 IPR036719  Neurotransmitter-gated ion-channel transmembrane domain superfamily
 IPR036734  Neurotransmitter-gated ion-channel ligand-binding domain superfamily


Gene Ontology (GO)
establishment of localizationcell communicationcellular response to stimulusresponse to chemicalregulation of biological qualitysystem processestablishment of localizationcell communicationcellular response to stimulusresponse to chemicalregulation of biological qualitysystem processestablishment of localizationcell communicationcellular response to stimulusresponse to chemicalregulation of biological qualitysystem processestablishment of localizationcell communicationcellular response to stimulusresponse to chemicalregulation of biological qualitysystem processestablishment of localizationcell communicationcellular response to stimulusresponse to chemicalregulation of biological qualitysystem processestablishment of localizationcell communicationcellular response to stimulusresponse to chemicalregulation of biological qualitysystem processestablishment of localizationcell communicationcellular response to stimulusresponse to chemicalregulation of biological qualitysystem processestablishment of localizationcell communicationcellular response to stimulusresponse to chemicalregulation of biological qualitysystem processestablishment of localizationcell communicationcellular response to stimulusresponse to chemicalregulation of biological qualitysystem processestablishment of localizationcell communicationcellular response to stimulusresponse to chemicalregulation of biological qualitysystem processestablishment of localiestablishment of localizationcell communicationcell communicationcellular response to stcellular response to stimulusresponse to chemicalresponse to chemicalregulation of biologicaregulation of biological qualitysystem processsystem process
signaling receptor activitytransmembrane transporter activityion bindingneurotransmitter bindingsmall molecule bindingdrug bindingsignaling receptor activitytransmembrane transporter activityion bindingneurotransmitter bindingsmall molecule bindingdrug bindingsignaling receptor activitytransmembrane transporter activityion bindingneurotransmitter bindingsmall molecule bindingdrug bindingsignaling receptor activitytransmembrane transporter activityion bindingneurotransmitter bindingsmall molecule bindingdrug bindingsignaling receptor activitytransmembrane transporter activityion bindingneurotransmitter bindingsmall molecule bindingdrug bindingsignaling receptor activitytransmembrane transporter activityion bindingneurotransmitter bindingsmall molecule bindingdrug bindingsignaling receptor activitytransmembrane transporter activityion bindingneurotransmitter bindingsmall molecule bindingdrug bindingsignaling receptor activitytransmembrane transporter activityion bindingneurotransmitter bindingsmall molecule bindingdrug bindingsignaling receptor activitytransmembrane transporter activityion bindingneurotransmitter bindingsmall molecule bindingdrug bindingsignaling receptor activitytransmembrane transporter activityion bindingneurotransmitter bindingsmall molecule bindingdrug bindingsignaling receptor actisignaling receptor activitytransmembrane transporttransmembrane transporter activityion bindingion bindingneurotransmitter bindinneurotransmitter bindingsmall molecule bindingsmall molecule bindingdrug bindingdrug binding
cellmembranecell junctionprotein-containing complexsynapsecellmembranecell junctionprotein-containing complexsynapsecellmembranecell junctionprotein-containing complexsynapsecellmembranecell junctionprotein-containing complexsynapsecellmembranecell junctionprotein-containing complexsynapsecellmembranecell junctionprotein-containing complexsynapsecellmembranecell junctionprotein-containing complexsynapsecellmembranecell junctionprotein-containing complexsynapsecellmembranecell junctionprotein-containing complexsynapsecellmembranecell junctionprotein-containing complexsynapsecellcellmembranemembranecell junctioncell junctionprotein-containing complexprotein-containing complexsynapsesynapse
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006821 chloride transport IEA
 biological_processGO:0007218 neuropeptide signaling pathway IBA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0043200 response to amino acid IEA
 biological_processGO:0060012 synaptic transmission, glycinergic IBA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:1902476 chloride transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0034707 chloride channel complex IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005230 extracellular ligand-gated ion channel activity IEA
 molecular_functionGO:0005254 chloride channel activity IEA
 molecular_functionGO:0016594 glycine binding IBA
 molecular_functionGO:0016934 extracellularly glycine-gated chloride channel activity IEA
 molecular_functionGO:0022824 transmitter-gated ion channel activity IEA


Pathways (from Reactome)
Pathway description
Neurotransmitter receptors and postsynaptic signal transmission


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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