ENSG00000146276


Homo sapiens

Features
Gene ID: ENSG00000146276
  
Biological name :GABRR1
  
Synonyms : GABRR1 / gamma-aminobutyric acid type A receptor rho1 subunit / P24046
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: q15
Gene start: 89177501
Gene end: 89231278
  
Corresponding Affymetrix probe sets: 206525_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000481986
Ensembl peptide - ENSP00000412673
Ensembl peptide - ENSP00000478846
Ensembl peptide - ENSP00000358463
Ensembl peptide - ENSP00000394687
Ensembl peptide - ENSP00000410130
NCBI entrez gene - 2569     See in Manteia.
OMIM - 137161
RefSeq - XM_017010689
RefSeq - NM_001256703
RefSeq - NM_001256704
RefSeq - NM_001267582
RefSeq - NM_002042
RefSeq Peptide - NP_001243632
RefSeq Peptide - NP_001243633
RefSeq Peptide - NP_001254511
RefSeq Peptide - NP_002033
swissprot - P24046
swissprot - F8WB88
Ensembl - ENSG00000146276
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FO704905.1ENSDARG00000098081Danio rerio
 gabrr1ENSDARG00000043902Danio rerio
 GABRR1ENSGALG00000015778Gallus gallus
 Gabrr1ENSMUSG00000028280Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GABRR2 / P28476 / gamma-aminobutyric acid type A receptor rho2 subunitENSG0000011188670
A8MPY1 / GABRR3 / gamma-aminobutyric acid type A receptor rho3 subunit (gene/pseudogene)ENSG0000018318558
GABRB2 / P47870 / gamma-aminobutyric acid type A receptor beta2 subunitENSG0000014586438
GABRB1 / P18505 / gamma-aminobutyric acid type A receptor beta1 subunitENSG0000016328837
GABRB3 / P28472 / gamma-aminobutyric acid type A receptor beta3 subunitENSG0000016620637
GABRP / O00591 / gamma-aminobutyric acid type A receptor pi subunitENSG0000009475532
GLRA3 / O75311 / glycine receptor alpha 3ENSG0000014545132
GLRA1 / P23415 / glycine receptor alpha 1ENSG0000014588831
GLRA2 / P23416 / glycine receptor alpha 2ENSG0000010195830
GABRD / O14764 / gamma-aminobutyric acid type A receptor delta subunitENSG0000018773030
GABRQ / Q9UN88 / gamma-aminobutyric acid type A receptor theta subunitENSG0000026808930
GLRB / P48167 / glycine receptor betaENSG0000010973829
GLRA4 / Q5JXX5 / glycine receptor alpha 4ENSG0000018882827


Protein motifs (from Interpro)
Interpro ID Name
 IPR006028  Gamma-aminobutyric acid A receptor/Glycine receptor alpha
 IPR006029  Neurotransmitter-gated ion-channel transmembrane domain
 IPR006201  Neurotransmitter-gated ion-channel
 IPR006202  Neurotransmitter-gated ion-channel ligand-binding domain
 IPR008057  Gamma-aminobutyric-acid A receptor, Rho
 IPR008058  Gamma-aminobutyric-acid A receptor, Rho1
 IPR018000  Neurotransmitter-gated ion-channel, conserved site
 IPR036719  Neurotransmitter-gated ion-channel transmembrane domain superfamily
 IPR036734  Neurotransmitter-gated ion-channel ligand-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006821 chloride transport IEA
 biological_processGO:0007214 gamma-aminobutyric acid signaling pathway TAS
 biological_processGO:0007268 chemical synaptic transmission TAS
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:1902476 chloride transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0034707 chloride channel complex IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:1902711 GABA-A receptor complex IBA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004890 GABA-A receptor activity TAS
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005230 extracellular ligand-gated ion channel activity IEA
 molecular_functionGO:0005254 chloride channel activity IEA


Pathways (from Reactome)
Pathway description
GABA A (rho) receptor activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000146276 GABRR1 / P24046 / gamma-aminobutyric acid type A receptor rho1 subunit  / complex
 ENSG00000111886 GABRR2 / P28476 / gamma-aminobutyric acid type A receptor rho2 subunit  / complex
 ENSG00000183185 A8MPY1 / GABRR3 / gamma-aminobutyric acid type A receptor rho3 subunit (gene/pseudogene)  / complex






 

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