ENSDARG00000007241


Danio rerio

Features
Gene ID: ENSDARG00000007241
  
Biological name :mycb
  
Synonyms : mycb / MYC proto-oncogene, bHLH transcription factor b / Q7ZVS9
  
Possible biological names infered from orthology : Bmyc / MYC / MYC proto-oncogene, bHLH transcription factor / myelocytomatosis oncogene / P01106 / P01108 / Protein B-Myc / Q6P8Z1
  
Species: Danio rerio
  
Chr. number: 2
Strand: 1
Band:
Gene start: 32016256
Gene end: 32018371
  
Corresponding Affymetrix probe sets: Dr.16048.1.S1_at (Zebrafish Array)   NM_200172_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000010970
Ensembl peptide - ENSDARP00000112522
NCBI entrez gene - 393141     See in Manteia.
RefSeq - NM_200172
RefSeq Peptide - NP_956466
swissprot - B2GQB7
swissprot - B0UY65
swissprot - Q7ZVS9
ZFIN ID - ZDB-GENE-040426-780
Ensembl - ENSDARG00000007241
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MYCENSGALG00000033631Gallus gallus
 MYCENSG00000136997Homo sapiens
 BmycENSMUSG00000049086Mus musculus
 MycENSMUSG00000022346Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
myca / MYC proto-oncogene, bHLH transcription factor a / MYC* / Bmyc* / P01106* / P01108* / Q6P8Z1* / Protein B-Myc * / myelocytomatosis oncogene* / MYC proto-oncogene, bHLH transcription factor*ENSDARG0000004569567
mycn / MYCN proto-oncogene, bHLH transcription factor / P03966* / P04198* / N-myc proto-onco protein *ENSDARG0000000683739
myclb / Q1LWL8 / MYCL proto-oncogene, bHLH transcription factor b / MYCL* / P10166* / P12524* / Protein L-Myc * / MYCL proto-oncogene, bHLH transcription factor*ENSDARG0000003495631
mycla / Q9PSI9 / MYCL proto-oncogene, bHLH transcription factor a / MYCL* / P10166* / P12524* / Protein L-Myc * / MYCL proto-oncogene, bHLH transcription factor*ENSDARG0000000600320
mych / myelocytomatosis oncogene homologENSDARG0000007747318


Protein motifs (from Interpro)
Interpro ID Name
 IPR002418  Transcription regulator Myc
 IPR003327  Leucine zipper, Myc
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR012682  Transcription regulator Myc, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0060216 definitive hemopoiesis IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases
TFAP2 (AP-2) family regulates transcription of cell cycle factors
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0005028 ventral wall of dorsal aorta ventral wall of dorsal aorta hematopoietic multipotent progenitor cell decreased distribution , abnormal
ventral wall of dorsal aorta hematopoietic multipotent progenitor cell decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000008880 usp28 / ubiquitin specific peptidase 28 / Q5I043* / Q96RU2*  / complex
 ENSDARG00000004111 esr1 / estrogen receptor 1 / P03372* / P19785* / Estrogen receptor *  / complex
 ENSDARG00000068436 Q6PI20 / h3f3b.1 / H3 histone, family 3B.1 / H3F3B* / H3F3C* / P84243* / Q6NXT2* / H3 histone family member 3C* / H3 histone family member 3B*  / complex
 ENSDARG00000105345 zgc:173552  / complex
 ENSDARG00000105359 Q4QRF4 / FP325123.1 / Histone H3.2   / complex
 ENSDARG00000024844 max / myc associated factor X / P61244* / Max protein*  / complex
 ENSDARG00000040606 tfap2c / transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) / Q61312* / Q92754* / transcription factor AP-2 gamma*  / complex / reaction






 

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