Manteia

ENSDARG00000008592

Danio rerio

Features

Gene ID:	ENSDARG00000008592

Biological name :	mtmr8

Synonyms :	mtmr8 / myotubularin related protein 8 / Q6TEL0

Possible biological names infered from orthology :	Q96EF0

Species:	Danio rerio

Chr. number:	5
Strand:	-1
Band:
Gene start:	22027588
Gene end:	22052852

Corresponding Affymetrix probe sets:	Dr.12335.1.A1_at (Zebrafish Array) Dr.17504.1.S1_at (Zebrafish Array)

Cross references:	Ensembl peptide - ENSDARP00000007263 swissprot - Q6TEL0 ZFIN ID - ZDB-GENE-040426-1016 Ensembl - ENSDARG00000008592

See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
mtmr6 / myotubularin related protein 6 / Q8VE11* / Q9Y217*	ENSDARG00000016794	55
mtmr7b / myotubularin related protein 7b / MTMR7* / Q9Z2C9* / Q9Y216* / myotubularin related protein 7*	ENSDARG00000070412	52
mtmr7a / myotubularin related protein 7a / MTMR7* / Q9Z2C9* / Q9Y216* / myotubularin related protein 7*	ENSDARG00000037101	51
mtmr2 / A0JMK5 / myotubularin related protein 2 / Q13614* / Q9Z2D1*	ENSDARG00000004616	32
mtm1 / myotubularin 1 / Q13496*	ENSDARG00000037560	32
mtmr1a / myotubularin related protein 1a / MTMR1* / Q9Z2C4* / Q13613* / myotubularin related protein 1*	ENSDARG00000056690	32
mtmr1b / myotubularin related protein 1b / MTMR1* / Q9Z2C4* / Q13613* / myotubularin related protein 1*	ENSDARG00000022378	31
mtmr9 / myotubularin related protein 9 / Q96QG7* / Q9Z2D0*	ENSDARG00000015860	30
zgc:154055	ENSDARG00000103924	27
sbf1 / SET binding factor 1 / O95248* / Q6ZPE2*	ENSDARG00000062968	24
sbf2 / SET binding factor 2 / Q86WG5*	ENSDARG00000059460	22
mtmr3 / myotubularin related protein 3 / Q13615*	ENSDARG00000093364	16
mtmr3 / myotubularin related protein 3 / Q13615*	ENSDARG00000098201	13

Protein motifs (from Interpro)

Interpro ID	Name
IPR003595	Protein-tyrosine phosphatase, catalytic
IPR010569	Myotubularin-like phosphatase domain
IPR011993	PH-like domain superfamily
IPR016130	Protein-tyrosine phosphatase, active site
IPR029021	Protein-tyrosine phosphatase-like
IPR030564	Myotubularin family
IPR030591	Myotubularin-related protein 8

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000165	MAPK cascade	IEA
biological_process	GO:0000187	activation of MAPK activity	IEA
biological_process	GO:0001568	blood vessel development	IMP
biological_process	GO:0010506	regulation of autophagy	IEA
biological_process	GO:0014065	phosphatidylinositol 3-kinase signaling	IMP
biological_process	GO:0016311	dephosphorylation	IEA
biological_process	GO:0035335	peptidyl-tyrosine dephosphorylation	IEA
biological_process	GO:0046856	phosphatidylinositol dephosphorylation	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005635	nuclear envelope	IEA
molecular_function	GO:0004438	phosphatidylinositol-3-phosphatase activity	IEA
molecular_function	GO:0004708	MAP kinase kinase activity	IMP
molecular_function	GO:0004725	protein tyrosine phosphatase activity	IEA
molecular_function	GO:0016787	hydrolase activity	IEA
molecular_function	GO:0052629	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	IEA

Pathways (from Reactome)

Pathway description

Synthesis of PIPs at the plasma membrane

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
ZFA:0000014	dorsal aorta	dorsal aorta decreased size , abnormal dorsal aorta decreased diameter , abnormal	Show
ZFA:0000155	somite	somite U-shaped , abnormal	Show
ZFA:0000477	posterior cardinal vein	posterior cardinal vein increased diameter , abnormal	Show
ZFA:0001058	caudal fin	caudal fin morphology , abnormal	Show
ZFA:0001114	head	head decreased size , abnormal head morphology , abnormal	Show
ZFA:0001115	trunk	trunk decreased length , abnormal trunk curved ventral , abnormal	Show
ZFA:0001285	intersegmental vessel	intersegmental vessel malformed , abnormal	Show
ZFA:0001286	caudal vein plexus	caudal vein plexus decreased width , abnormal caudal vein plexus decreased branchiness , abnormal	Show
ZFA:0005025	dorsal longitudinal anastomotic vessel	dorsal longitudinal anastomotic vessel malformed , abnormal	Show
ZFA:0005035	subintestinal vein	subintestinal vein absent , abnormal	Show
ZFA:0005295	axial blood vessel	axial blood vessel malformed , abnormal	Show
ZFA:0005297	cranial blood vessel	cranial blood vessel morphology , abnormal	Show
ZFA:0009116	slow muscle cell	slow muscle cell morphology , abnormal	Show

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSDARG00000015860	mtmr9 / myotubularin related protein 9 / Q96QG7* / Q9Z2D0*	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr