ENSDARG00000037560


Danio rerio

Features
Gene ID: ENSDARG00000037560
  
Biological name :mtm1
  
Synonyms : mtm1 / myotubularin 1
  
Possible biological names infered from orthology : Q13496 / Q9Z2C5 / X-linked myotubular myopathy gene 1
  
Species: Danio rerio
  
Chr. number: 7
Strand: 1
Band:
Gene start: 25825667
Gene end: 25854387
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000125098
NCBI entrez gene - 560881     See in Manteia.
RefSeq - NM_001037684
RefSeq Peptide - NP_001032773
swissprot - F8W5H1
ZFIN ID - ZDB-GENE-051113-128
Ensembl - ENSDARG00000037560
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MTM1ENSGALG00000009096Gallus gallus
 MTM1ENSG00000171100Homo sapiens
 Mtm1ENSMUSG00000031337Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
mtmr2 / A0JMK5 / myotubularin related protein 2 / Q13614* / Q9Z2D1*ENSDARG0000000461654
mtmr1a / myotubularin related protein 1a / MTMR1* / Q9Z2C4* / Q13613* / myotubularin related protein 1*ENSDARG0000005669052
mtmr1b / myotubularin related protein 1b / MTMR1* / Q9Z2C4* / Q13613* / myotubularin related protein 1*ENSDARG0000002237849
mtmr8 / Q6TEL0 / myotubularin related protein 8 / Q96EF0*ENSDARG0000000859232
mtmr6 / myotubularin related protein 6 / Q8VE11* / Q9Y217*ENSDARG0000001679432
mtmr7b / myotubularin related protein 7b / MTMR7* / Q9Z2C9* / Q9Y216* / myotubularin related protein 7*ENSDARG0000007041230
mtmr7a / myotubularin related protein 7a / MTMR7* / Q9Z2C9* / Q9Y216* / myotubularin related protein 7*ENSDARG0000003710129
mtmr9 / myotubularin related protein 9 / Q96QG7* / Q9Z2D0*ENSDARG0000001586026
sbf2 / SET binding factor 2 / Q86WG5*ENSDARG0000005946026
sbf1 / SET binding factor 1 / O95248* / Q6ZPE2*ENSDARG0000006296826
zgc:154055ENSDARG0000010392425
mtmr3 / myotubularin related protein 3 / Q13615*ENSDARG0000009336416
mtmr3 / myotubularin related protein 3 / Q13615*ENSDARG0000009820115


Protein motifs (from Interpro)
Interpro ID Name
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR004182  GRAM domain
 IPR010569  Myotubularin-like phosphatase domain
 IPR011993  PH-like domain superfamily
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR029021  Protein-tyrosine phosphatase-like
 IPR030561  Myotubularin
 IPR030564  Myotubularin family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007519 skeletal muscle tissue development IMP
 biological_processGO:0007525 somatic muscle development IMP
 biological_processGO:0007528 neuromuscular junction development IMP
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0008333 endosome to lysosome transport IEA
 biological_processGO:0010506 regulation of autophagy IGI
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0043009 chordate embryonic development IGI
 biological_processGO:0044088 regulation of vacuole organization IEA
 biological_processGO:0045109 intermediate filament organization IEA
 biological_processGO:0046716 muscle cell cellular homeostasis IEA
 biological_processGO:0046856 phosphatidylinositol dephosphorylation IEA
 biological_processGO:0048311 mitochondrion distribution IEA
 biological_processGO:0048741 skeletal muscle fiber development IMP
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005623 cell IEA
 molecular_functionGO:0004438 phosphatidylinositol-3-phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the plasma membrane
Synthesis of PIPs at the early endosome membrane
Synthesis of PIPs at the late endosome membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000006 ball ball deformed , abnormal
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 ZFA:0000106 extension extension aplastic , abnormal
extension decreased size , abnormal
Show

 ZFA:0000123 liver liver morphology , abnormal
Show

 ZFA:0000473 trunk musculature trunk musculature decreased size , abnormal
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 ZFA:0001069 ventral fin fold ventral fin fold absent , abnormal
ventral fin fold degeneration , ameliorated
ventral fin fold absence due to degeneration , abnormal
ventral fin fold degenerate , abnormal
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 ZFA:0001094 whole organism whole organism decreased length , abnormal
whole organism decreased size , abnormal
whole organism morphology , abnormal
whole organism edematous , abnormal
whole organism decreased mobility , abnormal
whole organism malformed , abnormal
whole organism life span , ameliorated
whole organism decreased life span , abnormal
Show

 ZFA:0001114 head head hypoplastic , abnormal
head decreased size , abnormal
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 ZFA:0001115 trunk trunk hypoplastic , abnormal
trunk curved dorsal , abnormal
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 ZFA:0001117 post-vent region post-vent region bent , abnormal
post-vent region decreased length , abnormal
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 ZFA:0001161 pectoral fin pectoral fin kinked , abnormal
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 ZFA:0005145 muscle muscle morphology , abnormal
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 ZFA:0005277 skeletal muscle skeletal muscle refractivity , abnormal
skeletal muscle non-functional , abnormal
skeletal muscle myofibril disorganized , abnormal
skeletal muscle sarcomere disorganized , abnormal
skeletal muscle Z disc absent , abnormal
skeletal muscle T-tubule disorganized , abnormal
skeletal muscle T-tubule absent , abnormal
skeletal muscle T-tubule broken , abnormal
skeletal muscle T-tubule lacks all parts of type skeletal muscle sarcoplasmic reticulum, abnormal
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 ZFA:0009114 muscle cell muscle cell nucleus displaced to muscle cell central region, abnormal
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 ZFA:0009115 skeletal muscle cell skeletal muscle cell morphology , abnormal
skeletal muscle cell nucleus irregular spatial pattern , abnormal
skeletal muscle cell mitochondrion morphology , abnormal
skeletal muscle cell vacuole morphology , abnormal
skeletal muscle cell endoplasmic reticulum decreased mass density , abnormal
skeletal muscle cell sarcoplasm disorganized , abnormal
skeletal muscle cell hypotrophic , abnormal
skeletal muscle cell decreased functionality , abnormal
skeletal muscle cell T-tubule disorganized , abnormal
skeletal muscle cell sarcoplasmic reticulum morphology , abnormal
skeletal muscle cell T-tubule morphology , abnormal
skeletal muscle cell perinuclear region of cytoplasm disorganized , abnormal
skeletal muscle cell separated from skeletal muscle cell , abnormal
skeletal muscle cell nucleus shape , abnormal
skeletal muscle cell nucleus increased size , abnormal
skeletal muscle cell nucleus mislocalised , abnormal
skeletal muscle cell sarcoplasmic reticulum disorganized , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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