ENSDARG00000011312


Danio rerio

Features
Gene ID: ENSDARG00000011312
  
Biological name :stk3
  
Synonyms : Q7ZUQ3 / serine/threonine kinase 3 (STE20 homolog, yeast) / stk3
  
Possible biological names infered from orthology : Mus musculus serine/threonine kinase 3 (Stk3), transcript variant 2, mRNA. / Q13188 / Q9JI10 / serine/threonine kinase 3
  
Species: Danio rerio
  
Chr. number: 19
Strand: 1
Band:
Gene start: 32807236
Gene end: 32820107
  
Corresponding Affymetrix probe sets: Dr.24253.1.S1_at (Zebrafish Array)   NM_199672_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000015367
NCBI entrez gene - 324125     See in Manteia.
RefSeq - NM_199672
RefSeq Peptide - NP_955966
swissprot - B2GP54
swissprot - Q7ZUQ3
ZFIN ID - ZDB-GENE-030131-2845
Ensembl - ENSDARG00000011312
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 STK3ENSGALG00000032850Gallus gallus
 STK3ENSG00000104375Homo sapiens
 Stk3ENSMUSG00000022329Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
stk25a / serine/threonine kinase 25a / STK25* / Q9Z2W1* / O00506* / serine/threonine kinase 25* / Serine/threonine-protein kinase 25 *ENSDARG0000000221035
stk24b / serine/threonine kinase 24b (STE20 homolog, yeast) / STK24* / Q99KH8* / Q9Y6E0* / serine/threonine kinase 24*ENSDARG0000002387835
stk25b / serine/threonine kinase 25b / STK25* / Q9Z2W1* / O00506* / serine/threonine kinase 25* / Serine/threonine-protein kinase 25 *ENSDARG0000003902235
stk26 / serine/threonine protein kinase 26 / Q9P289* / serine/threonine kinase 26*ENSDARG0000006039035
stk24a / serine/threonine kinase 24a (STE20 homolog, yeast) / STK24* / Q9Y6E0* / serine/threonine kinase 24*ENSDARG0000010095533


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR011524  SARAH domain
 IPR017441  Protein kinase, ATP binding site
 IPR024205  Mst1 SARAH domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IBA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0035329 hippo signaling ISS
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043010 camera-type eye development IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity ISS
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Signaling by Hippo


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000107 eye eye morphology , abnormal
eye pigmentation process quality , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased length , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000006196 sav1 / salvador family WW domain containing protein 1 / 1 * / Q8VEB2* / Q9H4B6*  / complex
 ENSDARG00000011312 stk3 / Q7ZUQ3 / serine/threonine kinase 3 (STE20 homolog, yeast) / Q13188* / Q9JI10* / serine/threonine kinase 3* / Mus musculus serine/threonine kinase 3 (Stk3), transcript variant 2, mRNA.*  / complex
 ENSDARG00000009169 mob1ba / MOB kinase activator 1Ba / MOB1B* / Q8BPB0* / Q7L9L4* / MOB kinase activator 1B*  / reaction
 ENSDARG00000003751 lats1 / large tumor suppressor kinase 1 / O95835* / Q8BYR2* / Serine/threonine-protein kinase LATS1 *  / reaction
 ENSDARG00000078864 lats2 / large tumor suppressor kinase 2 / Q7TSJ6* / Q9NRM7* / Serine/threonine-protein kinase LATS2 *  / reaction






 

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