ENSDARG00000013415


Danio rerio

Features
Gene ID: ENSDARG00000013415
  
Biological name :lmna
  
Synonyms : lamin A / lmna
  
Possible biological names infered from orthology : lamin A/C / P02545 / P48678 / Prelamin-A/C Lamin-A/C
  
Species: Danio rerio
  
Chr. number: 16
Strand: -1
Band:
Gene start: 30520357
Gene end: 30570161
  
Corresponding Affymetrix probe sets: Dr.10311.1.S1_at (Zebrafish Array)   Dr.10311.1.S2_at (Zebrafish Array)   Dr.8395.1.A1_at (Zebrafish Array)   NM_152971_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000153174
Ensembl peptide - ENSDARP00000156524
Ensembl peptide - ENSDARP00000113049
Ensembl peptide - ENSDARP00000145959
NCBI entrez gene - 195815     See in Manteia.
RefSeq - NM_152971
RefSeq - XM_005158167
RefSeq Peptide - NP_694503
swissprot - B3DKC5
ZFIN ID - ZDB-GENE-020424-3
Ensembl - ENSDARG00000013415
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LMNAENSG00000160789Homo sapiens
 LmnaENSMUSG00000028063Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
lmnb2 / lamin B2 / P21619* / Q03252*ENSDARG0000010162448
lmnb1 / lamin B1 / P14733* / P20700*ENSDARG0000004429945
lmnl3 / lamin L3ENSDARG0000000775137
desmb / desmin b / DES* / desmin* / P17661* / P31001*ENSDARG0000000522118
gfap / glial fibrillary acidic protein / P03995* / P14136*ENSDARG0000002530118
nefmb / neurofilament, medium polypeptide b / NEFM* / P07197* / neurofilament medium*ENSDARG0000004369718
viml / vimentin like / VIM* / P08670* / vimentin*ENSDARG0000004450118
desma / desmin a / DES* / desmin* / P17661* / P31001*ENSDARG0000005865618
vim / vimentin / P08670* / P20152*ENSDARG0000001000817
inaa / internexin neuronal intermediate filament protein, alpha a / INA* / Q16352* / P46660* / internexin neuronal intermediate filament protein alpha*ENSDARG0000001186217
zgc:65851ENSDARG0000001228117
neflb / neurofilament, light polypeptide b / NEFL* / P08551* / P07196* / neurofilament light* / Neurofilament light polypeptide *ENSDARG0000001242617
nefma / neurofilament, medium polypeptide a / NEFM* / P07197* / neurofilament medium*ENSDARG0000002135117
prph / peripherin / P41219*ENSDARG0000002830617
inab / internexin neuronal intermediate filament protein, alpha b / INA* / Q16352* / P46660* / internexin neuronal intermediate filament protein alpha*ENSDARG0000005324816
nefla / neurofilament, light polypeptide a / NEFL* / P08551* / P07196* / neurofilament light* / Neurofilament light polypeptide *ENSDARG0000005756816
ngs / notochord granular surfaceENSDARG0000005432115
zgc:136930ENSDARG0000005519215
si:dkey-33c12.3ENSDARG0000005788114
zgc:172323ENSDARG0000005320113


Protein motifs (from Interpro)
Interpro ID Name
 IPR001322  Lamin tail domain
 IPR001664  Intermediate filament protein
 IPR018039  Intermediate filament protein, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0060047 heart contraction IMP
 biological_processGO:0090342 regulation of cell aging IMP
 cellular_componentGO:0005882 intermediate filament IEA
 molecular_functionGO:0005198 structural molecule activity IEA


Pathways (from Reactome)
Pathway description
Breakdown of the nuclear lamina
Depolymerisation of the Nuclear Lamina


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain apoptotic , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000114 heart heart decreased contractility , abnormal
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 ZFA:0000154 sinus venosus sinus venosus increased accumulation blood , abnormal
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 ZFA:0000368 integument integument rough , abnormal
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 ZFA:0001056 myotome myotome slow muscle cell decreased amount , abnormal
myotome slow muscle cell undulate , abnormal
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 ZFA:0001115 trunk trunk apoptotic , abnormal
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 ZFA:0001205 Meckel s cartilage Meckels cartilage alignment palatoquadrate cartilage , abnormal
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 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage mislocalised posteriorly , abnormal
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 ZFA:0001460 pharyngeal arch cartilage pharyngeal arch cartilage physical object quality , abnormal
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 ZFA:0009082 fat cell fat cell decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000087554 cdk1 / cyclin-dependent kinase 1 / P06493* / P11440*  / reaction
 ENSDARG00000013415 lmna / lamin A / P02545* / P48678* / lamin A/C* / Prelamin-A/C Lamin-A/C*  / complex






 

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