ENSDARG00000022101


Danio rerio

Features
Gene ID: ENSDARG00000022101
  
Biological name :obscnb
  
Synonyms : obscnb / obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF b
  
Possible biological names infered from orthology : OBSCN / obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF / Q5VST9
  
Species: Danio rerio
  
Chr. number: 24
Strand: 1
Band:
Gene start: 35933869
Gene end: 36002202
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000142063
Ensembl peptide - ENSDARP00000142069
Ensembl peptide - ENSDARP00000142503
Ensembl peptide - ENSDARP00000129075
swissprot - A0A140LFP0
swissprot - A0A140LFP6
swissprot - A0A140LGX4
swissprot - X1WFS0
ZFIN ID - ZDB-GENE-070119-5
Ensembl - ENSDARG00000022101
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 OBSCNENSGALG00000032534Gallus gallus
 OBSCNENSG00000154358Homo sapiens
 ObscnENSMUSG00000061462Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ttn.1 / titin, tandem duplicate 1 / TTN* / titin* / A2ASS6* / Q8WZ42*ENSDARG0000000056322
ttn.2 / titin, tandem duplicate 2 / TTN* / titin* / A2ASS6* / Q8WZ42*ENSDARG0000002821322
obsl1b / obscurin-like 1b / OBSL1* / D3YYU8* / O75147* / obscurin like 1* / Obscurin-like protein 1 *ENSDARG0000007738822
hmcn1 / hemicentin 1 / D3YXG0* / Q96RW7*ENSDARG0000001693619
obsl1a / obscurin-like 1a / OBSL1* / O75147* / obscurin like 1*ENSDARG0000000368418
hmcn2 / hemicentin 2 / A2AJ76* / Q8NDA2*ENSDARG0000007932710
igsf10 / immunoglobulin superfamily, member 10 / Q3V1M1* / Q6WRI0*ENSDARG000000774976
mxra5b / matrix-remodelling associated 5b / MXRA5* / Q9NR99* / matrix remodeling associated 5*ENSDARG000000763095
mxra5a / matrix-remodelling associated 5a / MXRA5* / Q9NR99* / matrix remodeling associated 5*ENSDARG000000748154
si:ch211-159i8.4ENSDARG000000763324
palld / palladin, cytoskeletal associated protein / Q8WX93* / Q9ET54* / Palladin *ENSDARG000000400093
CU928131.1ENSDARG000001092623
myot / myotilinENSDARG000000763120
hmcn2 / hemicentin 2ENSDARG000000860600


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR000219  Dbl homology (DH) domain
 IPR001452  SH3 domain
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR035526  Obscurin, SH3 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030239 myofibril assembly IMP
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0055002 striated muscle cell development IMP
 biological_processGO:0060041 retina development in camera-type eye IMP
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0031430 M band IDA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000009 cardiac ventricle cardiac ventricle decreased size , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
eye hypoplastic , abnormal
Show

 ZFA:0000114 heart heart dilated , abnormal
heart decreased functionality , abnormal
heart structure , abnormal
heart decreased size , abnormal
Show

 ZFA:0000610 vertical myoseptum vertical myoseptum disorganized , abnormal
vertical myoseptum morphology , abnormal
vertical myoseptum decreased size , abnormal
Show

 ZFA:0000671 horizontal myoseptum horizontal myoseptum aplastic , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased length , abnormal
Show

 ZFA:0001114 head head decreased size , abnormal
Show

 ZFA:0001117 post-vent region post-vent region decreased length , abnormal
post-vent region decreased width , abnormal
Show

 ZFA:0001202 optic cup optic cup morphology , abnormal
Show

 ZFA:0001617 otolith otolith decreased amount , abnormal
Show

 ZFA:0009115 skeletal muscle cell skeletal muscle cell nucleus shape , abnormal
skeletal muscle cell myofibril decreased amount , abnormal
skeletal muscle cell sarcomere structure , abnormal
skeletal muscle cell Z disc structure , abnormal
skeletal muscle cell M band decreased amount , abnormal
skeletal muscle cell elongated , abnormal
skeletal muscle cell sarcoplasmic reticulum disorganized , abnormal
skeletal muscle cell myofibril disorganized , abnormal
skeletal muscle cell striated muscle myosin thick filament disorganized , abnormal
skeletal muscle cell myofibril orientation skeletal muscle cell , abnormal
Show

 ZFA:0009127 photoreceptor cell photoreceptor cell absent , abnormal
Show

 ZFA:0009316 cardiac muscle cell cardiac muscle cell structure , abnormal
cardiac muscle cell intercalated disc absent , abnormal
cardiac muscle cell myofibril decreased amount , abnormal
cardiac muscle cell myofibril disorganized , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr