ENSDARG00000028071


Danio rerio

Features
Gene ID: ENSDARG00000028071
  
Biological name :bmp1a
  
Synonyms : bmp1a / bone morphogenetic protein 1a
  
Possible biological names infered from orthology : BMP1 / bone morphogenetic protein 1 / Bone morphotic protein 1 / P13497 / P98063
  
Species: Danio rerio
  
Chr. number: 8
Strand: -1
Band:
Gene start: 51165392
Gene end: 51293301
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000112455
Ensembl peptide - ENSDARP00000150341
NCBI entrez gene - 572452     See in Manteia.
RefSeq - NM_001040037
RefSeq - XM_017357365
RefSeq Peptide - NP_001035126
swissprot - F1REM3
ZFIN ID - ZDB-GENE-060818-1
Ensembl - ENSDARG00000028071
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BMP1ENSG00000168487Homo sapiens
 Bmp1ENSMUSG00000022098Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
bmp1b / bone morphogenetic protein 1b / BMP1* / P98063* / P13497* / Bone morphotic protein 1 * / bone morphogenetic protein 1*ENSDARG0000002805378
tll1 / O57460 / tolloid-like 1 / O43897* / tolloid-like*ENSDARG0000003742972
cubn / cubilin (intrinsic factor-cobalamin receptor) / O60494* / cubilin*ENSDARG0000008701327
cdcp2 / CUB domain containing protein 2 / Q5VXM1* / Q8BQH6*ENSDARG0000007586613
pcolcea / procollagen C-endopeptidase enhancer a / Q61398* / PCOLCE* / Q15113* / procollagen C-endopeptidase enhancer* / Procollagen C-endopeptidase enhancer 1 *ENSDARG0000005691312
pcolce2a / procollagen C-endopeptidase enhancer 2a / Q9UKZ9* / Q8R4W6* / PCOLCE2* / procollagen C-endopeptidase enhancer 2*ENSDARG0000000845011
pcolceb / procollagen C-endopeptidase enhancer b / Q61398* / PCOLCE* / Q15113* / procollagen C-endopeptidase enhancer* / Procollagen C-endopeptidase enhancer 1 *ENSDARG0000005205711
si:cabz01033205.3 / MFRP* / Q8K480* / Q9BY79* / membrane frizzled-related protein*ENSDARG0000008781411
neto2b / neuropilin (NRP) and tolloid (TLL)-like 2b / NETO2* / Q8NC67* / neuropilin and tolloid like 2*ENSDARG0000011210011
pimr62 / pcolce2b / procollagen C-endopeptidase enhancer 2b / Q9UKZ9* / Q8R4W6* / PCOLCE2* / procollagen C-endopeptidase enhancer 2*ENSDARG0000005557510
neto2b / neuropilin (NRP) and tolloid (TLL)-like 2b / NETO2* / Q8NC67* / Q8BNJ6* / neuropilin and tolloid like 2* / Mus musculus neuropilin (NRP) and tolloid (TLL)-like 2 (Neto2), transcrip...ENSDARG0000006329310
neto1 / neuropilin (NRP) and tolloid (TLL)-like 1 / Q8TDF5* / Q8R4I7* / neuropilin and tolloid like 1* / Neuropilin and tolloid-like protein 1 *ENSDARG0000006848310
neto1l / neuropilin (NRP) and tolloid (TLL)-like 1, like / NETO1* / Q8TDF5* / Q8R4I7* / neuropilin and tolloid like 1* / Neuropilin and tolloid-like protein 1 *ENSDARG0000007159610


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR000859  CUB domain
 IPR001506  Peptidase M12A
 IPR001881  EGF-like calcium-binding domain
 IPR006026  Peptidase, metallopeptidase
 IPR013032  EGF-like, conserved site
 IPR015446  Bone morphogenetic protein 1/tolloid-like protein
 IPR018097  EGF-like calcium-binding, conserved site
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR034036  Tolloid/BMP1 peptidase domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IMP
 biological_processGO:0006508 proteolysis IDA
 biological_processGO:0009953 dorsal/ventral pattern formation IMP
 biological_processGO:0033333 fin development IMP
 biological_processGO:0048264 determination of ventral identity IMP
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IDA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
Collagen biosynthesis and modifying enzymes
Anchoring fibril formation
Crosslinking of collagen fibrils
HDL assembly


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000040 median fin fold median fin fold undulate , abnormal
median fin fold decreased length , abnormal
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 ZFA:0000108 fin fin malformed , abnormal
fin decreased length , abnormal
fin undulate , abnormal
fin decreased size , abnormal
fin fibrillar collagen trimer disorganized , abnormal
fin shape , abnormal
fin deformed , abnormal
fin has fewer parts of type lepidotrichium , abnormal
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 ZFA:0000126 centrum centrum fibrillar collagen trimer disorganized , abnormal
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 ZFA:0000292 surface structure surface structure quality , abnormal
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 ZFA:0000317 postcranial axial skeleton postcranial axial skeleton increased curvature , abnormal
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 ZFA:0000737 cranium cranium malformed , abnormal
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 ZFA:0001058 caudal fin caudal fin lepidotrichium decreased size , abnormal
caudal fin shape , abnormal
caudal fin deformed , abnormal
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 ZFA:0001066 neural arch neural arch increased area , abnormal
neural arch decreased angle to vertebra , abnormal
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 ZFA:0001069 ventral fin fold ventral fin fold decreased length , abnormal
ventral fin fold undulate , abnormal
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 ZFA:0001094 whole organism whole organism shape , abnormal
whole organism wholly dorsalized , abnormal
whole organism decreased length , abnormal
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 ZFA:0001115 trunk trunk increased curvature , abnormal
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 ZFA:0001161 pectoral fin pectoral fin quality , abnormal
pectoral fin decreased size , abnormal
pectoral fin undulate , abnormal
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 ZFA:0001162 anal fin anal fin lepidotrichium decreased size , abnormal
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 ZFA:0001173 dorsal fin dorsal fin lepidotrichium decreased size , abnormal
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 ZFA:0001184 pelvic fin pelvic fin decreased size , abnormal
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 ZFA:0001189 vertebra vertebra increased mass density , abnormal
vertebra shape , abnormal
vertebra decreased mass density , abnormal
vertebra fused with vertebra , abnormal
vertebra morphology , abnormal
vertebra increased size , abnormal
vertebra increased volume , abnormal
vertebra bone mineralization process quality , abnormal
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 ZFA:0001554 lepidotrichium lepidotrichium fused with lepidotrichium , abnormal
lepidotrichium undulate , abnormal
lepidotrichium decreased mass density , abnormal
lepidotrichium broken , abnormal
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 ZFA:0009031 osteoblast osteoblast cuboid , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000012076 apoa1a / O42363 / apolipoprotein A-Ia / APOA1* / Q00623* / P02647* / apolipoprotein A1* / Apolipoprotein A-I Proapolipoprotein A-I Truncated apolipoprotein A-I*  / reaction
 ENSDARG00000101324 apoa1b / apolipoprotein A-Ib / APOA1* / P02647* / apolipoprotein A1*  / reaction






 

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