ENSDARG00000029432


Danio rerio

Features
Gene ID: ENSDARG00000029432
  
Biological name :tph1a
  
Synonyms : tph1a / tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) a
  
Possible biological names infered from orthology : P17532 / P17752 / TPH1 / tryptophan hydroxylase 1
  
Species: Danio rerio
  
Chr. number: 25
Strand: -1
Band:
Gene start: 8139220
Gene end: 8160030
  
Corresponding Affymetrix probe sets: Dr.15967.1.A1_at (Zebrafish Array)   Dr.19931.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000067158
NCBI entrez gene - 352943     See in Manteia.
RefSeq - XM_017354058
swissprot - F1R1D3
ZFIN ID - ZDB-GENE-030317-1
Ensembl - ENSDARG00000029432
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TPH1ENSGALG00000006236Gallus gallus
 TPH1ENSG00000129167Homo sapiens
 Tph1ENSMUSG00000040046Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tph1b / tryptophan hydroxylase 1b / TPH1* / P17752* / P17532* / tryptophan hydroxylase 1*ENSDARG0000003608280
tph2 / tryptophan hydroxylase 2 (tryptophan 5-monooxygenase) / Q8IWU9* / Q8CGV2* / tryptophan hydroxylase 2* / Tryptophan 5-hydroxylase 2 *ENSDARG0000005723968
pah / phenylalanine hydroxylase / P00439* / P16331* / Phenylalanine-4-hydroxylase *ENSDARG0000002014352
th2 / tyrosine hydroxylase 2ENSDARG0000003838447
th / tyrosine hydroxylase / P07101* / P24529*ENSDARG0000003062146


Protein motifs (from Interpro)
Interpro ID Name
 IPR001273  Aromatic amino acid hydroxylase
 IPR002912  ACT domain
 IPR005963  Tryptophan 5-monooxygenase
 IPR018301  Aromatic amino acid hydroxylase, iron/copper binding site
 IPR019773  Tyrosine 3-monooxygenase-like
 IPR019774  Aromatic amino acid hydroxylase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009072 aromatic amino acid family metabolic process IEA
 biological_processGO:0042427 serotonin biosynthetic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:1902036 regulation of hematopoietic stem cell differentiation IGI
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0004510 tryptophan 5-monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Serotonin and melatonin biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001094 whole organism whole organism morphology , abnormal
whole organism dead , abnormal
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 ZFA:0005028 ventral wall of dorsal aorta ventral wall of dorsal aorta hematopoietic multipotent progenitor cell decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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