ENSDARG00000057239


Danio rerio

Features
Gene ID: ENSDARG00000057239
  
Biological name :tph2
  
Synonyms : tph2 / tryptophan hydroxylase 2 (tryptophan 5-monooxygenase)
  
Possible biological names infered from orthology : Q8CGV2 / Q8IWU9 / Tryptophan 5-hydroxylase 2 / tryptophan hydroxylase 2
  
Species: Danio rerio
  
Chr. number: 18
Strand: -1
Band:
Gene start: 16989764
Gene end: 17001056
  
Corresponding Affymetrix probe sets: Dr.14052.1.A1_at (Zebrafish Array)   NM_214795_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000074283
Ensembl peptide - ENSDARP00000102919
NCBI entrez gene - 407712     See in Manteia.
RefSeq - NM_001310068
RefSeq - NM_214795
RefSeq Peptide - NP_001296997
RefSeq Peptide - NP_999960
swissprot - Q1LUE3
swissprot - Q1LUE4
ZFIN ID - ZDB-GENE-040624-4
Ensembl - ENSDARG00000057239
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TPH2ENSGALG00000010198Gallus gallus
 TPH2ENSG00000139287Homo sapiens
 Tph2ENSMUSG00000006764Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tph1a / tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) a / TPH1* / P17752* / P17532* / tryptophan hydroxylase 1*ENSDARG0000002943266
tph1b / tryptophan hydroxylase 1b / TPH1* / P17752* / P17532* / tryptophan hydroxylase 1*ENSDARG0000003608263
pah / phenylalanine hydroxylase / P00439* / P16331* / Phenylalanine-4-hydroxylase *ENSDARG0000002014349
th / tyrosine hydroxylase / P07101* / P24529*ENSDARG0000003062145
th2 / tyrosine hydroxylase 2ENSDARG0000003838443


Protein motifs (from Interpro)
Interpro ID Name
 IPR001273  Aromatic amino acid hydroxylase
 IPR002912  ACT domain
 IPR005963  Tryptophan 5-monooxygenase
 IPR018301  Aromatic amino acid hydroxylase, iron/copper binding site
 IPR019773  Tyrosine 3-monooxygenase-like
 IPR019774  Aromatic amino acid hydroxylase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009072 aromatic amino acid family metabolic process IEA
 biological_processGO:0042427 serotonin biosynthetic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:1902036 regulation of hematopoietic stem cell differentiation IMP
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0004510 tryptophan 5-monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Serotonin and melatonin biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000037 anatomical structure anatomical structure cortisol amount , ameliorated
Show

 ZFA:0005028 ventral wall of dorsal aorta ventral wall of dorsal aorta hematopoietic multipotent progenitor cell decreased amount , abnormal
Show

 ZFA:0009354 hematopoietic multipotent progenitor cell hematopoietic multipotent progenitor cell decreased amount , abnormal
hematopoietic multipotent progenitor cell amount , ameliorated
hematopoietic multipotent progenitor cell decreased distribution , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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