ENSGALG00000010198


Gallus gallus

Features
Gene ID: ENSGALG00000010198
  
Biological name :TPH2
  
Synonyms : TPH2 / tryptophan hydroxylase 2
  
Possible biological names infered from orthology : Q8CGV2 / Q8IWU9 / Tryptophan 5-hydroxylase 2
  
Species: Gallus gallus
  
Chr. number: 1
Strand: 1
Band:
Gene start: 36509695
Gene end: 36563986
  
Corresponding Affymetrix probe sets: Gga.19488.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000060473
Ensembl peptide - ENSGALP00000037703
NCBI entrez gene - 408026     See in Manteia.
RefSeq - NM_001001301
RefSeq Peptide - NP_001001301
swissprot - Q6PKI7
swissprot - A0A1L1RNW4
Ensembl - ENSGALG00000010198
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tph2ENSDARG00000057239Danio rerio
 TPH2ENSG00000139287Homo sapiens
 Tph2ENSMUSG00000006764Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TPH1 / P70080 / Tryptophan 5-hydroxylase 1 / P17752* / P17532* / tryptophan hydroxylase 1*ENSGALG0000000623672
PAH / phenylalanine hydroxylase / P00439* / P16331* / Phenylalanine-4-hydroxylase *ENSGALG0000001275451
TH / tyrosine hydroxylase / P07101* / P24529*ENSGALG0000002964847
ENSGALG0000001930043


Protein motifs (from Interpro)
Interpro ID Name
 IPR001273  Aromatic amino acid hydroxylase
 IPR002912  ACT domain
 IPR005963  Tryptophan 5-monooxygenase
 IPR018301  Aromatic amino acid hydroxylase, iron/copper binding site
 IPR019773  Tyrosine 3-monooxygenase-like
 IPR019774  Aromatic amino acid hydroxylase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009072 aromatic amino acid family metabolic process IEA
 biological_processGO:0042427 serotonin biosynthetic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0043005 neuron projection IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0004510 tryptophan 5-monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Serotonin and melatonin biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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