ENSGALG00000006236


Gallus gallus

Features
Gene ID: ENSGALG00000006236
  
Biological name :TPH1
  
Synonyms : P70080 / TPH1 / Tryptophan 5-hydroxylase 1
  
Possible biological names infered from orthology : P17532 / P17752 / tryptophan hydroxylase 1
  
Species: Gallus gallus
  
Chr. number: 5
Strand: -1
Band:
Gene start: 12458129
Gene end: 12468744
  
Corresponding Affymetrix probe sets: Gga.4291.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000063172
Ensembl peptide - ENSGALP00000010070
NCBI entrez gene - 395799     See in Manteia.
RefSeq - XM_015286577
RefSeq - NM_204956
RefSeq Peptide - NP_990287
swissprot - P70080
swissprot - A0A1L1RWF7
Ensembl - ENSGALG00000006236
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tph1aENSDARG00000029432Danio rerio
 tph1bENSDARG00000036082Danio rerio
 TPH1ENSG00000129167Homo sapiens
 Tph1ENSMUSG00000040046Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TPH2 / tryptophan hydroxylase 2 / Q8CGV2* / Q8IWU9* / Tryptophan 5-hydroxylase 2 *ENSGALG0000001019874
PAH / phenylalanine hydroxylase / P00439* / P16331* / Phenylalanine-4-hydroxylase *ENSGALG0000001275451
TH / tyrosine hydroxylase / P07101* / P24529*ENSGALG0000002964849
ENSGALG0000001930044


Protein motifs (from Interpro)
Interpro ID Name
 IPR001273  Aromatic amino acid hydroxylase
 IPR002912  ACT domain
 IPR005963  Tryptophan 5-monooxygenase
 IPR018301  Aromatic amino acid hydroxylase, iron/copper binding site
 IPR019773  Tyrosine 3-monooxygenase-like
 IPR019774  Aromatic amino acid hydroxylase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009072 aromatic amino acid family metabolic process IEA
 biological_processGO:0042427 serotonin biosynthetic process IEA
 biological_processGO:0045600 positive regulation of fat cell differentiation IEA
 biological_processGO:0046849 bone remodeling IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060749 mammary gland alveolus development IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0004510 tryptophan 5-monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Serotonin and melatonin biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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