ENSGALG00000012754


Gallus gallus

Features
Gene ID: ENSGALG00000012754
  
Biological name :PAH
  
Synonyms : PAH / phenylalanine hydroxylase
  
Possible biological names infered from orthology : P00439 / P16331 / Phenylalanine-4-hydroxylase
  
Species: Gallus gallus
  
Chr. number: 1
Strand: 1
Band:
Gene start: 55129804
Gene end: 55165880
  
Corresponding Affymetrix probe sets: Gga.10235.1.S1_at (Chicken Array)   Gga.12887.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000052587
Ensembl peptide - ENSGALP00000020786
NCBI entrez gene - 408024     See in Manteia.
RefSeq - NM_001001298
RefSeq Peptide - NP_001001298
swissprot - Q6PKI8
swissprot - A0A1D5PIF4
Ensembl - ENSGALG00000012754
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pahENSDARG00000020143Danio rerio
 PAHENSG00000171759Homo sapiens
 PahENSMUSG00000020051Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TPH2 / tryptophan hydroxylase 2 / Q8CGV2* / Q8IWU9* / Tryptophan 5-hydroxylase 2 *ENSGALG0000001019856
TPH1 / P70080 / Tryptophan 5-hydroxylase 1 / P17752* / P17532* / tryptophan hydroxylase 1*ENSGALG0000000623654
TH / tyrosine hydroxylase / P07101* / P24529*ENSGALG0000002964852
ENSGALG0000001930048


Protein motifs (from Interpro)
Interpro ID Name
 IPR001273  Aromatic amino acid hydroxylase
 IPR002912  ACT domain
 IPR005961  Phenylalanine-4-hydroxylase, tetrameric form
 IPR018301  Aromatic amino acid hydroxylase, iron/copper binding site
 IPR019773  Tyrosine 3-monooxygenase-like
 IPR019774  Aromatic amino acid hydroxylase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006559 L-phenylalanine catabolic process IEA
 biological_processGO:0009072 aromatic amino acid family metabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0004505 phenylalanine 4-monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Phenylalanine and tyrosine catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000012754 PAH / phenylalanine hydroxylase / P00439* / P16331* / Phenylalanine-4-hydroxylase *  / complex






 

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