ENSDARG00000037833


Danio rerio
transcriptionmitfbfactoractivitymittfefactorsdna-templatedregulationrnapolymeraseiimyc-typebasichelix-loop-helixbhlhdomainc-terminalmicrophthalmia-associatedn-terminalmelanocytedifferentiationnucleusnucleoplasmsequence-specificdnabindingdna-bindingproteindimerization

Features
Gene ID: ENSDARG00000037833
  
Biological name :mitfb
  
Synonyms : microphthalmia-associated transcription factor b / mitfb
  
Possible biological names infered from orthology : melanogenesis associated transcription factor / MITF / O75030 / Q08874
  
Species: Danio rerio
  
Chr. number: 23
Strand: -1
Band:
Gene start: 711075
Gene end: 764135
  
Corresponding Affymetrix probe sets: Dr.12631.1.S1_at (Zebrafish Array)   NM_131847_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000021876
Ensembl peptide - ENSDARP00000149281
NCBI entrez gene - 114833     See in Manteia.
RefSeq - NM_131847
RefSeq Peptide - NP_571922
swissprot - F1Q885
ZFIN ID - ZDB-GENE-010919-1
Ensembl - ENSDARG00000037833
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MITFENSGALG00000039583Gallus gallus
 MITFENSG00000187098Homo sapiens
 MitfENSMUSG00000035158Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
mitfa / microphthalmia-associated transcription factor a / MITF* / O75030* / Q08874* / melanogenesis associated transcription factor*ENSDARG0000000373256
tfe3a / transcription factor binding to IGHM enhancer 3a / TFE3* / Q64092* / P19532* / Transcription factor E3 * / transcription factor binding to IGHM enhancer 3*ENSDARG0000009890349
tfe3b / transcription factor binding to IGHM enhancer 3b / TFE3* / Q64092* / P19532* / Transcription factor E3 * / transcription factor binding to IGHM enhancer 3*ENSDARG0000001945747
tfeb / transcription factor EB / P19484* / Q9R210*ENSDARG0000001079442
tfec / transcription factor EC / O14948*ENSDARG0000009874533


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR021802  MiT/TFE transcription factors, C-terminal
 IPR030532  Microphthalmia-associated transcription factor
 IPR031867  MiT/TFE transcription factors, N-terminal


Gene Ontology (GO)
nitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular developmental processdevelopmental pigmentationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular developmental processdevelopmental pigmentationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular developmental processdevelopmental pigmentationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular developmental processdevelopmental pigmentationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular developmental processdevelopmental pigmentationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular developmental processdevelopmental pigmentationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular developmental processdevelopmental pigmentationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular developmental processdevelopmental pigmentationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular developmental processdevelopmental pigmentationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular developmental processdevelopmental pigmentationnitrogen compound menitrogen compound metabolic processbiosynthetic processbiosynthetic processcellular metabolic pcellular metabolic processprimary metabolic prprimary metabolic processorganic substance meorganic substance metabolic processcellular developmentcellular developmental processdevelopmental pigmendevelopmental pigmentation
DNA-binding transcription factor activityprotein bindingDNA-binding transcription factor activityprotein bindingDNA-binding transcription factor activityprotein bindingDNA-binding transcription factor activityprotein bindingDNA-binding transcription factor activityprotein bindingDNA-binding transcription factor activityprotein bindingDNA-binding transcription factor activityprotein bindingDNA-binding transcription factor activityprotein bindingDNA-binding transcription factor activityprotein bindingDNA-binding transcription factor activityprotein bindingDNA-binding transcription factor activityDNA-binding transcription factor activityprotein bindingprotein binding
cellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellorganellemembrane-enclosed lumencellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumen
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IDA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0030318 melanocyte differentiation IGI
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IC
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000044267 sumo1 / Q7SZR5 / small ubiquitin-like modifier 1 / P63166* / P63165* / Small ubiquitin-related modifier 1 *  / complex






 

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