ENSDARG00000038643


Danio rerio

Features
Gene ID: ENSDARG00000038643
  
Biological name :alas2
  
Synonyms : alas2 / aminolevulinate, delta-, synthase 2 / Q9YHT4
  
Possible biological names infered from orthology : 5-aminolevulinate synthase 2 / 5-aminolevulinate synthase, erythroid-specific, mitochondrial / P08680 / P22557
  
Species: Danio rerio
  
Chr. number: 8
Strand: 1
Band:
Gene start: 21353878
Gene end: 21369028
  
Corresponding Affymetrix probe sets: Dr.8180.1.S1_at (Zebrafish Array)   NM_131682_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000056419
NCBI entrez gene - 64607     See in Manteia.
RefSeq - NM_131682
RefSeq Peptide - NP_571757
swissprot - Q9YHT4
ZFIN ID - ZDB-GENE-001229-1
Ensembl - ENSDARG00000038643
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ALAS2ENSG00000158578Homo sapiens
 Alas2ENSMUSG00000025270Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
alas1 / aminolevulinate, delta-, synthase 1 / P13196* / Q8VC19* / 5-aminolevulinate synthase 1* / 5-aminolevulinate synthase, nonspecific, mitochondrial *ENSDARG0000002105960
gcat / glycine C-acetyltransferase / O75600* / O88986* / 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial *ENSDARG0000000564322


Protein motifs (from Interpro)
Interpro ID Name
 IPR001917  Aminotransferase, class-II, pyridoxal-phosphate binding site
 IPR004839  Aminotransferase, class I/classII
 IPR010961  Tetrapyrrole biosynthesis, 5-aminolevulinic acid synthase
 IPR015118  5-aminolevulinate synthase presequence
 IPR015421  Pyridoxal phosphate-dependent transferase, major domain
 IPR015422  Pyridoxal phosphate-dependent transferase domain 1
 IPR015424  Pyridoxal phosphate-dependent transferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia ISS
 biological_processGO:0006778 porphyrin-containing compound metabolic process IEA
 biological_processGO:0006782 protoporphyrinogen IX biosynthetic process IEA
 biological_processGO:0006783 heme biosynthetic process ISS
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009058 biosynthetic process IEA
 biological_processGO:0020027 hemoglobin metabolic process IMP
 biological_processGO:0030218 erythrocyte differentiation ISS
 biological_processGO:0033014 tetrapyrrole biosynthetic process IEA
 biological_processGO:0035162 embryonic hemopoiesis IMP
 biological_processGO:0042541 hemoglobin biosynthetic process ISS
 biological_processGO:0048821 erythrocyte development IMP
 cellular_componentGO:0005739 mitochondrion ISS
 cellular_componentGO:0005743 mitochondrial inner membrane ISS
 cellular_componentGO:0005759 mitochondrial matrix IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003870 5-aminolevulinate synthase activity ISS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0030170 pyridoxal phosphate binding IEA


Pathways (from Reactome)
Pathway description
Heme biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood quality , abnormal
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 ZFA:0000114 heart heart increased size , abnormal
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 ZFA:0001094 whole organism whole organism viability , abnormal
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 ZFA:0001439 anatomical system anatomical system quality , abnormal
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 ZFA:0005236 basophilic erythroblast basophilic erythroblast increased size , abnormal
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 ZFA:0005237 erythroblast erythroblast increased amount , abnormal
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 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte lacks all parts of type nucleate erythrocyte hemoglobin complex, abnormal
nucleate erythrocyte desaturated blue , abnormal
nucleate erythrocyte decreased amount , abnormal
nucleate erythrocyte low saturation , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000038643 alas2 / Q9YHT4 / aminolevulinate, delta-, synthase 2 / P08680* / P22557* / 5-aminolevulinate synthase 2* / 5-aminolevulinate synthase, erythroid-specific, mitochondrial *  / complex






 

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