ENSDARG00000021059


Danio rerio

Features
Gene ID: ENSDARG00000021059
  
Biological name :alas1
  
Synonyms : alas1 / aminolevulinate, delta-, synthase 1
  
Possible biological names infered from orthology : 5-aminolevulinate synthase 1 / 5-aminolevulinate synthase, nonspecific, mitochondrial / P13196 / Q8VC19
  
Species: Danio rerio
  
Chr. number: 11
Strand: -1
Band:
Gene start: 260763
Gene end: 270210
  
Corresponding Affymetrix probe sets: Dr.4829.1.A1_at (Zebrafish Array)   NM_201287_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000005771
Ensembl peptide - ENSDARP00000142602
NCBI entrez gene - 64608     See in Manteia.
RefSeq - NM_201287
RefSeq Peptide - NP_958444
swissprot - F1RB22
swissprot - A0A140LH72
ZFIN ID - ZDB-GENE-001229-2
Ensembl - ENSDARG00000021059
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ALAS1ENSGALG00000003948Gallus gallus
 ALAS1ENSG00000023330Homo sapiens
 Alas1ENSMUSG00000032786Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
alas2 / Q9YHT4 / aminolevulinate, delta-, synthase 2 / P08680* / P22557* / 5-aminolevulinate synthase 2* / 5-aminolevulinate synthase, erythroid-specific, mitochondrial *ENSDARG0000003864356
gcat / glycine C-acetyltransferase / O75600* / O88986* / 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial *ENSDARG0000000564321


Protein motifs (from Interpro)
Interpro ID Name
 IPR004839  Aminotransferase, class I/classII
 IPR010961  Tetrapyrrole biosynthesis, 5-aminolevulinic acid synthase
 IPR015118  5-aminolevulinate synthase presequence
 IPR015421  Pyridoxal phosphate-dependent transferase, major domain
 IPR015422  Pyridoxal phosphate-dependent transferase domain 1
 IPR015424  Pyridoxal phosphate-dependent transferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006778 porphyrin-containing compound metabolic process IEA
 biological_processGO:0006782 protoporphyrinogen IX biosynthetic process IEA
 biological_processGO:0006783 heme biosynthetic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009058 biosynthetic process IEA
 biological_processGO:0033014 tetrapyrrole biosynthetic process IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005759 mitochondrial matrix IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003870 5-aminolevulinate synthase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0030170 pyridoxal phosphate binding IEA


Pathways (from Reactome)
Pathway description
Heme biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000021059 alas1 / aminolevulinate, delta-, synthase 1 / P13196* / Q8VC19* / 5-aminolevulinate synthase 1* / 5-aminolevulinate synthase, nonspecific, mitochondrial *  / complex






 

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