ENSDARG00000041609


Danio rerio

Features
Gene ID: ENSDARG00000041609
  
Biological name :adarb1a
  
Synonyms : adarb1a / adenosine deaminase, RNA-specific, B1a
  
Possible biological names infered from orthology : ADARB1 / adenosine deaminase, RNA specific B1 / Double-stranded RNA-specific editase 1 / P78563 / Q91ZS8
  
Species: Danio rerio
  
Chr. number: 22
Strand: -1
Band:
Gene start: 12641580
Gene end: 12693837
  
Corresponding Affymetrix probe sets: Dr.10298.1.S1_a_at (Zebrafish Array)   NM_131610_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000044573
Ensembl peptide - ENSDARP00000105962
NCBI entrez gene - 58134     See in Manteia.
RefSeq - NM_131610
RefSeq - XM_021469375
RefSeq Peptide - NP_571685
swissprot - A5WUX1
swissprot - A5WUX0
ZFIN ID - ZDB-GENE-000627-2
Ensembl - ENSDARG00000041609
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ADARB1ENSGALG00000007527Gallus gallus
 ADARB1ENSG00000197381Homo sapiens
 Adarb1ENSMUSG00000020262Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
adarb1b / adenosine deaminase, RNA-specific, B1b / ADARB1* / P78563* / Q91ZS8* / adenosine deaminase, RNA specific B1* / Double-stranded RNA-specific editase 1 *ENSDARG0000000354481
adarb2 / adenosine deaminase, RNA-specific, B2 (non-functional) / Q9JI20* / Q9NS39* / adenosine deaminase, RNA-specific, B2* / adenosine deaminase, RNA specific B2 (inactive)*ENSDARG0000007182349
adar / adenosine deaminase, RNA-specific / P55265* / Q99MU3* / Mus musculus adenosine deaminase, RNA-specific (Adar), transcript variant 4, mRNA.*ENSDARG0000001238930
adad1 / adenosine deaminase domain containing 1 (testis-specific) / Q96M93* / adenosine deaminase domain containing 1*ENSDARG0000008918119
adad2 / adenosine deaminase domain containing 2 / Q8NCV1*ENSDARG0000010562616
adat1 / adenosine deaminase, tRNA-specific 1 / Q9BUB4* / Q9JHI2* / Mus musculus adenosine deaminase, tRNA-specific 1 (Adat1), transcript variant 3, mRNA.*ENSDARG0000006134814


Protein motifs (from Interpro)
Interpro ID Name
 IPR002466  Adenosine deaminase/editase
 IPR014720  Double-stranded RNA-binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006396 RNA processing IEA
 biological_processGO:0007399 nervous system development IMP
 biological_processGO:0014032 neural crest cell development IMP
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IMP
 biological_processGO:0048899 anterior lateral line development IMP
 biological_processGO:0048916 posterior lateral line development IMP
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004000 adenosine deaminase activity IEA


Pathways (from Reactome)
Pathway description
C6 deamination of adenosine
Formation of editosomes by ADAR proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000029 hindbrain hindbrain apoptotic process increased process quality , abnormal
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 ZFA:0000075 spinal cord spinal cord has fewer parts of type motor neuron , abnormal
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 ZFA:0000107 eye eye apoptotic process increased process quality , abnormal
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 ZFA:0000110 fourth ventricle fourth ventricle increased size , abnormal
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 ZFA:0000128 midbrain midbrain apoptotic process increased process quality , abnormal
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 ZFA:0000161 third ventricle third ventricle increased size , abnormal
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 ZFA:0000671 horizontal myoseptum horizontal myoseptum apoptotic process increased process quality , abnormal
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 ZFA:0000940 posterior lateral line neuromast posterior lateral line neuromast decreased amount , abnormal
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 ZFA:0001114 head head decreased size , abnormal
head apoptotic process increased process quality , abnormal
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 ZFA:0001115 trunk trunk apoptotic process increased process quality , abnormal
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 ZFA:0001306 pharyngeal arch pharyngeal arch decreased size , abnormal
pharyngeal arch absent , abnormal
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 ZFA:0001321 neurocranial trabecula neurocranial trabecula decreased size , abnormal
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 ZFA:0001405 ethmoid cartilage ethmoid cartilage absent , abnormal
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 ZFA:0001423 parachordal cartilage parachordal cartilage decreased size , abnormal
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 ZFA:0001458 cranial cartilage cranial cartilage malformed , abnormal
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 ZFA:0001472 anterior lateral line neuromast anterior lateral line neuromast decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000041609 adarb1a / adenosine deaminase, RNA-specific, B1a / ADARB1* / P78563* / Q91ZS8* / adenosine deaminase, RNA specific B1* / Double-stranded RNA-specific editase 1 *  / complex / reaction
 ENSDARG00000003544 adarb1b / adenosine deaminase, RNA-specific, B1b / ADARB1* / P78563* / Q91ZS8* / adenosine deaminase, RNA specific B1* / Double-stranded RNA-specific editase 1 *  / reaction / complex






 

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