ENSDARG00000042252


Danio rerio
bindingeif4hrnarecognitionmotifcomplexsribosomaldomaineifhnucleicacidla-mediatedtranslationalsilencingceruloplasminexpressiontranslationinitiationformationactivationmrnacap-bindingeifssubsequentscanningstartcodongtp

Features
Gene ID: ENSDARG00000042252
  
Biological name :eif4h
  
Synonyms : eif4h / eukaryotic translation initiation factor 4h
  
Possible biological names infered from orthology : Q15056 / Q9WUK2
  
Species: Danio rerio
  
Chr. number: 15
Strand: -1
Band:
Gene start: 4585266
Gene end: 4616928
  
Corresponding Affymetrix probe sets: Dr.7659.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000117924
Ensembl peptide - ENSDARP00000119123
Ensembl peptide - ENSDARP00000130536
Ensembl peptide - ENSDARP00000131876
NCBI entrez gene - 402996     See in Manteia.
RefSeq - NM_001197328
RefSeq - NM_001197329
RefSeq Peptide - NP_001184257
RefSeq Peptide - NP_001184258
swissprot - F1QYM4
swissprot - A0A0R4ICV9
swissprot - A0A0R4IG09
swissprot - F1R2E7
ZFIN ID - ZDB-GENE-010328-19
Ensembl - ENSDARG00000042252
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EIF4HENSGALG00000001313Gallus gallus
 EIF4HENSG00000106682Homo sapiens
 Eif4hENSMUSG00000040731Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
eif4ba / eukaryotic translation initiation factor 4Ba / EIF4B* / Q8BGD9* / P23588* / eukaryotic translation initiation factor 4B*ENSDARG0000001743939
eif4bb / eukaryotic translation initiation factor 4Bb / EIF4B* / Q8BGD9* / P23588* / eukaryotic translation initiation factor 4B*ENSDARG0000001019436


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR034229  eIF4H, RNA recognition motif


Gene Ontology (GO)
organic cyclic compound bindingheterocyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingorganic cyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingheterocyclic compound binding
TypeGO IDTermEv.Code
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA


Pathways (from Reactome)
Pathway description
L13a-mediated translational silencing of Ceruloplasmin expression
Translation initiation complex formation
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000005827 eif2s1a / eukaryotic translation initiation factor 2, subunit 1 alpha a / Q6ZWX6* / P05198* / EIF2S1* / Eukaryotic translation initiation factor 2 subunit 1 * / eukaryotic translation initi...  / reaction
 ENSDARG00000008292 eif2s3 / F1QGW6 / eukaryotic translation initiation factor 2, subunit 3 gamma / Q9Z0N2* / P41091* / Q2VIR3* / Q9Z0N1* / EIF2S3B* / Eif2s3x* / Eif2s3y* / eukaryotic translation initiation fa...  / reaction
 ENSDARG00000017219 pabpc1a / poly(A) binding protein, cytoplasmic 1a / PABPC1* / Pabpc2* / PABPC3* / Pabpc6* / Q9H361* / P11940* / P29341* / Polyadenylate-binding protein 1 * / poly(A) binding protein cytopla...  / reaction
 ENSDARG00000021140 pabpc1b / poly A binding protein, cytoplasmic 1 b / PABPC1* / Pabpc2* / PABPC3* / Pabpc6* / Q9H361* / P11940* / P29341* / Polyadenylate-binding protein 1 * / poly(A) binding protein cytopla...  / reaction
 ENSDARG00000052178 eif2s1b / eukaryotic translation initiation factor 2, subunit 1 alpha b / Q6ZWX6* / P05198* / EIF2S1* / Eukaryotic translation initiation factor 2 subunit 1 * / eukaryotic translation initi...  / reaction
 ENSDARG00000057912 eif1axb / eukaryotic translation initiation factor 1A, X-linked, b / Eif1a* / Q8BMJ3* / EIF1AX* / EIF1AY* / Gm4027* / Gm5039* / Gm5662* / Gm5788* / Gm6803* / Gm8300* / Gm8332* / O14602* / P...  / reaction
 ENSDARG00000029003 eif1axa / eukaryotic translation initiation factor 1A, X-linked, a / Eif1a* / Q8BMJ3* / EIF1AX* / EIF1AY* / Gm4027* / Gm5039* / Gm5662* / Gm5788* / Gm6803* / Gm8300* / Gm8332* / O14602* / P...  / reaction
 ENSDARG00000003032 eif4a1b / eukaryotic translation initiation factor 4A1B / EIF4A1* / P60842* / P60843* / Eukaryotic initiation factor 4A-I * / eukaryotic translation initiation factor 4A1*  / complex
 ENSDARG00000092115 eif4a1a / eukaryotic translation initiation factor 4A1A / EIF4A1* / P60842* / P60843* / Eukaryotic initiation factor 4A-I * / eukaryotic translation initiation factor 4A1*  / complex
 ENSDARG00000016477 eif4a2 / eukaryotic translation initiation factor 4A, isoform 2 / P10630* / Q14240* / eukaryotic translation initiation factor 4A2* / Mus musculus eukaryotic translation initiation factor 4...  / complex






 

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