ENSDARG00000021140


Danio rerio

Features
Gene ID: ENSDARG00000021140
  
Biological name :pabpc1b
  
Synonyms : pabpc1b / poly A binding protein, cytoplasmic 1 b
  
Possible biological names infered from orthology : P11940 / P29341 / PABPC1 / Pabpc2 / PABPC3 / Pabpc6 / poly(A) binding protein cytoplasmic 1 / poly(A) binding protein cytoplasmic 3 / Polyadenylate-binding protein 1 / Q9H361
  
Species: Danio rerio
  
Chr. number: 19
Strand: -1
Band:
Gene start: 12121944
Gene end: 12145765
  
Corresponding Affymetrix probe sets: Dr.11392.1.A1_at (Zebrafish Array)   NM_200882_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000034822
Ensembl peptide - ENSDARP00000117257
Ensembl peptide - ENSDARP00000126202
NCBI entrez gene - 393856     See in Manteia.
RefSeq - NM_200882
RefSeq Peptide - NP_957176
swissprot - I3ITD9
swissprot - B8JLJ5
swissprot - Q6P3L1
ZFIN ID - ZDB-GENE-050308-1
Ensembl - ENSDARG00000021140
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PABPC1ENSGALG00000030280Gallus gallus
 P11940ENSG00000070756Homo sapiens
 PABPC3ENSG00000151846Homo sapiens
 P29341ENSMUSG00000022283Mus musculus
 Pabpc2ENSMUSG00000051732Mus musculus
 Pabpc6ENSMUSG00000046173Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pabpc1a / poly(A) binding protein, cytoplasmic 1a / PABPC1* / Pabpc2* / PABPC3* / Pabpc6* / Q9H361* / P11940* / P29341* / Polyadenylate-binding protein 1 * / poly(A) binding protein cytopla...ENSDARG0000001721992
pabpc4 / poly(A) binding protein, cytoplasmic 4 (inducible form) / Q13310* / P0CB38* / PABPC4L* / poly(A) binding protein cytoplasmic 4* / poly(A) binding protein cytoplasmic 4 like*ENSDARG0000005925977
pabpc1l / poly(A) binding protein, cytoplasmic 1-like / Q4VXU2*ENSDARG0000000259772
rbms3 / RNA binding motif, single stranded interacting protein / Q6XE24* / Q8BWL5* / RNA binding motif single stranded interacting protein 3*ENSDARG0000004457416
rbms1a / RNA binding motif, single stranded interacting protein 1a / RBMS1* / Q91W59* / P29558* / RNA binding motif single stranded interacting protein 1*ENSDARG0000007402316
rbms2b / RNA binding motif, single stranded interacting protein 2b / RBMS2* / Q8VC70* / Q15434* / RNA binding motif single stranded interacting protein 2*ENSDARG0000005615015
rbms2a / RNA binding motif, single stranded interacting protein 2a / RBMS2* / Q8VC70* / Q15434* / RNA binding motif single stranded interacting protein 2*ENSDARG0000004417914
puf60a / poly-U binding splicing factor a / PUF60* / Q3UEB3* / Q9UHX1* / poly(U) binding splicing factor 60* / Poly(U)-binding-splicing factor PUF60 *ENSDARG0000003217513
Q6IQE0 / puf60b / poly-U binding splicing factor b / PUF60* / Q3UEB3* / Q9UHX1* / poly(U) binding splicing factor 60* / Poly(U)-binding-splicing factor PUF60 *ENSDARG0000000124112
elavl1a / ELAV like RNA binding protein 1a / Q15717* / P70372* / ELAVL1* / ELAV-like protein 1 * / ELAV like RNA binding protein 1*ENSDARG0000003869512
elavl2 / ELAV like neuron-specific RNA binding protein 2 / Q12926* / Q60899* / ELAV like RNA binding protein 2* / Mus musculus ELAV like RNA binding protein 1 (Elavl2), transcript variant 5, mRNA.*ENSDARG0000004073212
elavl4 / ELAV like neuron-specific RNA binding protein 4 / P26378* / Q61701* / ELAV like RNA binding protein 4* / Mus musculus ELAV like RNA binding protein 4 (Elavl4), transcript variant 5, mRNA.*ENSDARG0000004563912
elavl3 / ELAV like neuron-specific RNA binding protein 3 / Q60900* / Q14576* / ELAV-like protein 3 * / ELAV like RNA binding protein 3*ENSDARG0000001442011
elavl1b / ELAV like RNA binding protein 1b / Q15717* / P70372* / ELAVL1* / ELAV-like protein 1 * / ELAV like RNA binding protein 1*ENSDARG0000010174411
RBMS1 (1 of many) / RNA binding motif single stranded interacting protein 1 / RBMS1* / P29558*ENSDARG000001038239


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR002004  Polyadenylate-binding protein/Hyperplastic disc protein
 IPR003954  RNA recognition motif domain, eukaryote
 IPR006515  Polyadenylate binding protein, human types 1, 2, 3, 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA


Pathways (from Reactome)
Pathway description
L13a-mediated translational silencing of Ceruloplasmin expression
Deadenylation of mRNA
AUF1 (hnRNP D0) binds and destabilizes mRNA
Translation initiation complex formation
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000005827 eif2s1a / eukaryotic translation initiation factor 2, subunit 1 alpha a / Q6ZWX6* / P05198* / EIF2S1* / Eukaryotic translation initiation factor 2 subunit 1 * / eukaryotic translation initi...  / reaction
 ENSDARG00000014898 ncbp2 / Q8JGR6 / nuclear cap binding protein subunit 2 / Q9CQ49* / NCBP2L* / P52298* / A6PVI3* / nuclear cap binding protein subunit 2 like*  / complex
 ENSDARG00000003032 eif4a1b / eukaryotic translation initiation factor 4A1B / EIF4A1* / P60842* / P60843* / Eukaryotic initiation factor 4A-I * / eukaryotic translation initiation factor 4A1*  / reaction
 ENSDARG00000008292 eif2s3 / F1QGW6 / eukaryotic translation initiation factor 2, subunit 3 gamma / Q9Z0N2* / P41091* / Q2VIR3* / Q9Z0N1* / EIF2S3B* / Eif2s3x* / Eif2s3y* / eukaryotic translation initiation fa...  / reaction
 ENSDARG00000052178 eif2s1b / eukaryotic translation initiation factor 2, subunit 1 alpha b / Q6ZWX6* / P05198* / EIF2S1* / Eukaryotic translation initiation factor 2 subunit 1 * / eukaryotic translation initi...  / reaction
 ENSDARG00000092115 eif4a1a / eukaryotic translation initiation factor 4A1A / EIF4A1* / P60842* / P60843* / Eukaryotic initiation factor 4A-I * / eukaryotic translation initiation factor 4A1*  / reaction
 ENSDARG00000016477 eif4a2 / eukaryotic translation initiation factor 4A, isoform 2 / P10630* / Q14240* / eukaryotic translation initiation factor 4A2* / Mus musculus eukaryotic translation initiation factor 4...  / reaction
 ENSDARG00000042252 eif4h / eukaryotic translation initiation factor 4h / Q15056* / Q9WUK2*  / reaction
 ENSDARG00000057912 eif1axb / eukaryotic translation initiation factor 1A, X-linked, b / Eif1a* / Q8BMJ3* / EIF1AX* / EIF1AY* / Gm4027* / Gm5039* / Gm5662* / Gm5788* / Gm6803* / Gm8300* / Gm8332* / O14602* / P...  / reaction
 ENSDARG00000029003 eif1axa / eukaryotic translation initiation factor 1A, X-linked, a / Eif1a* / Q8BMJ3* / EIF1AX* / EIF1AY* / Gm4027* / Gm5039* / Gm5662* / Gm5788* / Gm6803* / Gm8300* / Gm8332* / O14602* / P...  / reaction






 

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