ENSDARG00000057912


Danio rerio

Features
Gene ID: ENSDARG00000057912
  
Biological name :eif1axb
  
Synonyms : eif1axb / eukaryotic translation initiation factor 1A, X-linked, b
  
Possible biological names infered from orthology : BB287469 / Eif1a / EIF1AX / EIF1AY / Eukaryotic translation initiation factor 1A / Eukaryotic translation initiation factor 1A, X-chromosomal / eukaryotic translation initiation factor 1A, X-linked / eukaryotic translation initiation factor 1A, Y-linked / expressed sequence BB287469 / Gm16368 / Gm2016 / Gm2022 / Gm2035 / Gm2056 / Gm2075 / Gm21319 / Gm21936 / Gm4027 / Gm5039 / Gm5662 / Gm5788 / Gm6803 / Gm8300 / Gm8332 / O14602 / P47813 / predicted 6803 / Q60872 / Q8BMJ3
  
Species: Danio rerio
  
Chr. number: 24
Strand: -1
Band:
Gene start: 24164227
Gene end: 24168533
  
Corresponding Affymetrix probe sets: Dr.20386.2.S1_at (Zebrafish Array)   Dr.20386.2.S1_a_at (Zebrafish Array)   Dr.20386.3.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000118291
Ensembl peptide - ENSDARP00000075117
NCBI entrez gene - 322599     See in Manteia.
RefSeq - NM_001025453
RefSeq Peptide - NP_001020624
swissprot - E9QJN5
swissprot - Q4V9N9
ZFIN ID - ZDB-GENE-030131-1319
Ensembl - ENSDARG00000057912
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EIF1AYENSGALG00000016410Gallus gallus
 EIF1AXENSG00000173674Homo sapiens
 EIF1AYENSG00000198692Homo sapiens
 BB287469ENSMUSG00000079031Mus musculus
 Eif1aENSMUSG00000057561Mus musculus
 Eif1axENSMUSG00000067194Mus musculus
 Gm16368ENSMUSG00000114075Mus musculus
 Gm2016ENSMUSG00000072905Mus musculus
 Gm2022ENSMUSG00000113971Mus musculus
 Gm2035ENSMUSG00000096619Mus musculus
 Gm2056ENSMUSG00000095717Mus musculus
 Gm2075ENSMUSG00000096049Mus musculus
 Gm21319ENSMUSG00000095724Mus musculus
 Gm21936ENSMUSG00000113201Mus musculus
 Gm4027ENSMUSG00000092019Mus musculus
 Gm5039ENSMUSG00000093847Mus musculus
 Gm5662ENSMUSG00000079029Mus musculus
 Gm5788ENSMUSG00000113805Mus musculus
 Gm6803ENSMUSG00000096803Mus musculus
 Gm8300ENSMUSG00000079034Mus musculus
 Gm8332ENSMUSG00000095799Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
eif1axa / eukaryotic translation initiation factor 1A, X-linked, a / Eif1a* / Q8BMJ3* / EIF1AX* / EIF1AY* / Gm4027* / Gm5039* / Gm5662* / Gm5788* / Gm6803* / Gm8300* / Gm8332* / O14602* / P...ENSDARG0000002900396


Protein motifs (from Interpro)
Interpro ID Name
 IPR001253  Translation initiation factor 1A (eIF-1A)
 IPR006196  RNA-binding domain, S1, IF1 type
 IPR012340  Nucleic acid-binding, OB-fold
 IPR018104  Translation initiation factor 1A (eIF-1A), conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006412 translation IEA
 biological_processGO:0006413 translational initiation IEA
 biological_processGO:0043249 erythrocyte maturation IMP
 biological_processGO:0046984 regulation of hemoglobin biosynthetic process IMP
 biological_processGO:1903798 regulation of production of miRNAs involved in gene silencing by miRNA IMP
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003743 translation initiation factor activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
L13a-mediated translational silencing of Ceruloplasmin expression
Translation initiation complex formation
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000037 anatomical structure anatomical structure increased amount , abnormal
Show

 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000005827 eif2s1a / eukaryotic translation initiation factor 2, subunit 1 alpha a / Q6ZWX6* / P05198* / EIF2S1* / Eukaryotic translation initiation factor 2 subunit 1 * / eukaryotic translation initi...  / complex / reaction
 ENSDARG00000003032 eif4a1b / eukaryotic translation initiation factor 4A1B / EIF4A1* / P60842* / P60843* / Eukaryotic initiation factor 4A-I * / eukaryotic translation initiation factor 4A1*  / reaction
 ENSDARG00000008292 eif2s3 / F1QGW6 / eukaryotic translation initiation factor 2, subunit 3 gamma / Q9Z0N2* / P41091* / Q2VIR3* / Q9Z0N1* / EIF2S3B* / Eif2s3x* / Eif2s3y* / eukaryotic translation initiation fa...  / complex / reaction
 ENSDARG00000017219 pabpc1a / poly(A) binding protein, cytoplasmic 1a / PABPC1* / Pabpc2* / PABPC3* / Pabpc6* / Q9H361* / P11940* / P29341* / Polyadenylate-binding protein 1 * / poly(A) binding protein cytopla...  / reaction
 ENSDARG00000021140 pabpc1b / poly A binding protein, cytoplasmic 1 b / PABPC1* / Pabpc2* / PABPC3* / Pabpc6* / Q9H361* / P11940* / P29341* / Polyadenylate-binding protein 1 * / poly(A) binding protein cytopla...  / reaction
 ENSDARG00000052178 eif2s1b / eukaryotic translation initiation factor 2, subunit 1 alpha b / Q6ZWX6* / P05198* / EIF2S1* / Eukaryotic translation initiation factor 2 subunit 1 * / eukaryotic translation initi...  / complex / reaction
 ENSDARG00000057912 eif1axb / eukaryotic translation initiation factor 1A, X-linked, b / Eif1a* / Q8BMJ3* / EIF1AX* / EIF1AY* / Gm4027* / Gm5039* / Gm5662* / Gm5788* / Gm6803* / Gm8300* / Gm8332* / O14602* / P...  / reaction
 ENSDARG00000092115 eif4a1a / eukaryotic translation initiation factor 4A1A / EIF4A1* / P60842* / P60843* / Eukaryotic initiation factor 4A-I * / eukaryotic translation initiation factor 4A1*  / reaction
 ENSDARG00000016477 eif4a2 / eukaryotic translation initiation factor 4A, isoform 2 / P10630* / Q14240* / eukaryotic translation initiation factor 4A2* / Mus musculus eukaryotic translation initiation factor 4...  / reaction
 ENSDARG00000042252 eif4h / eukaryotic translation initiation factor 4h / Q15056* / Q9WUK2*  / reaction
 ENSDARG00000029003 eif1axa / eukaryotic translation initiation factor 1A, X-linked, a / Eif1a* / Q8BMJ3* / EIF1AX* / EIF1AY* / Gm4027* / Gm5039* / Gm5662* / Gm5788* / Gm6803* / Gm8300* / Gm8332* / O14602* / P...  / reaction






 

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