ENSDARG00000045067


Danio rerio

Features
Gene ID: ENSDARG00000045067
  
Biological name :kcnk1a
  
Synonyms : kcnk1a / potassium channel, subfamily K, member 1a
  
Possible biological names infered from orthology : KCNK1 / O00180 / O08581 / Potassium channel subfamily K member 1 / potassium two pore domain channel subfamily K member 1
  
Species: Danio rerio
  
Chr. number: 12
Strand: 1
Band:
Gene start: 30705769
Gene end: 30712111
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000066258
Ensembl peptide - ENSDARP00000156387
Ensembl peptide - ENSDARP00000120366
NCBI entrez gene - 793480     See in Manteia.
RefSeq - NM_001098753
RefSeq Peptide - NP_001092223
swissprot - E9QGL8
swissprot - A5PLK0
ZFIN ID - ZDB-GENE-070620-26
Ensembl - ENSDARG00000045067
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 KCNK1ENSGALG00000011005Gallus gallus
 KCNK1ENSG00000135750Homo sapiens
 Kcnk1ENSMUSG00000033998Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
kcnk1b / potassium channel, subfamily K, member 1b / KCNK1* / O08581* / O00180* / Potassium channel subfamily K member 1 * / potassium two pore domain channel subfamily K member 1*ENSDARG0000001725472
kcnk6 / potassium channel, subfamily K, member 6 / Q9Y257* / potassium two pore domain channel subfamily K member 6* / potassium inwardly-rectifying channel, subfamily K, member 6*ENSDARG0000000738341
kcnk7 / potassium channel, subfamily K, member 7 / Q9Y2U2* / potassium two pore domain channel subfamily K member 7*ENSDARG0000005733137
kcnk10b / potassium channel, subfamily K, member 10b / P57789* / KCNK10* / potassium channel, subfamily K, member 10* / potassium two pore domain channel subfamily K member 10*ENSDARG0000004595628
kcnk10a / potassium channel, subfamily K, member 10a / P57789* / KCNK10* / potassium channel, subfamily K, member 10* / potassium two pore domain channel subfamily K member 10*ENSDARG0000006284927
kcnk2a / potassium channel, subfamily K, member 2a / KCNK2* / O95069* / P97438* / potassium two pore domain channel subfamily K member 2* / Mus musculus potassium channel, subfamily K, memb...ENSDARG0000005512326
kcnk2b / potassium channel, subfamily K, member 2b / KCNK2* / O95069* / P97438* / potassium two pore domain channel subfamily K member 2* / Mus musculus potassium channel, subfamily K, memb...ENSDARG0000000715125
kcnk4a / potassium channel, subfamily K, member 4a / KCNK4* / Q9NYG8* / O88454* / Potassium channel subfamily K member 4 * / potassium two pore domain channel subfamily K member 4*ENSDARG0000010328624
kcnk3a / potassium channel, subfamily K, member 3a / KCNK3* / O35111* / O14649* / Potassium channel subfamily K member 3 * / potassium two pore domain channel subfamily K member 3*ENSDARG0000004346623
kcnk3b / potassium channel, subfamily K, member 3b / KCNK3* / O35111* / O14649* / Potassium channel subfamily K member 3 * / potassium two pore domain channel subfamily K member 3*ENSDARG0000005289823
kcnk5b / potassium channel, subfamily K, member 5bENSDARG0000001239022
kcnk9 / potassium channel, subfamily K, member 9 / Q3LS21* / Q9NPC2* / potassium two pore domain channel subfamily K member 9*ENSDARG0000010456322
kcnk5a / potassium channel, subfamily K, member 5a / KCNK5* / O95279* / potassium two pore domain channel subfamily K member 5*ENSDARG0000002358721
kcnk15 / potassium channel, subfamily K, member 15 / Q9H427* / potassium two pore domain channel subfamily K member 15*ENSDARG0000007737121
kcnk17 / potassium channel, subfamily K, member 17 / Q96T54* / potassium two pore domain channel subfamily K member 17*ENSDARG0000010545321


Protein motifs (from Interpro)
Interpro ID Name
 IPR001779  Two pore domain potassium channel, TWIK-1
 IPR003092  Two pore domain potassium channel, TASK family
 IPR003280  Two pore domain potassium channel
 IPR005408  Two pore domain potassium channel, TWIK family
 IPR013099  Potassium channel domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003015 heart process IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0030322 stabilization of membrane potential IBA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005267 potassium channel activity IDA
 molecular_functionGO:0015271 outward rectifier potassium channel activity IDA
 molecular_functionGO:0022841 potassium ion leak channel activity IBA


Pathways (from Reactome)
Pathway description
Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)
Phase 4 - resting membrane potential


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000114 heart heart increased size , abnormal
heart elongated , abnormal
Show

 ZFA:0000471 atrium atrium dilated , abnormal
Show

 ZFA:0001117 post-vent region post-vent region decreased length , abnormal
post-vent region increased curvature , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000017254 kcnk1b / potassium channel, subfamily K, member 1b / KCNK1* / O08581* / O00180* / Potassium channel subfamily K member 1 * / potassium two pore domain channel subfamily K member 1*  / complex
 ENSDARG00000045067 kcnk1a / potassium channel, subfamily K, member 1a / KCNK1* / O08581* / O00180* / Potassium channel subfamily K member 1 * / potassium two pore domain channel subfamily K member 1*  / complex






 

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