ENSDARG00000054755


Danio rerio

Features
Gene ID: ENSDARG00000054755
  
Biological name :alox5ap
  
Synonyms : alox5ap / arachidonate 5-lipoxygenase-activating protein
  
Possible biological names infered from orthology : P20292 / P30355
  
Species: Danio rerio
  
Chr. number: 10
Strand: 1
Band:
Gene start: 36458563
Gene end: 36463715
  
Corresponding Affymetrix probe sets: Dr.7610.1.A1_at (Zebrafish Array)   NM_200061_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000071476
NCBI entrez gene - 337376     See in Manteia.
RefSeq - NM_200061
RefSeq Peptide - NP_956355
swissprot - F1QKS8
ZFIN ID - ZDB-GENE-030131-9322
Ensembl - ENSDARG00000054755
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ALOX5APENSGALG00000026781Gallus gallus
 P20292ENSG00000132965Homo sapiens
 P30355ENSMUSG00000060063Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ltc4s / leukotriene C4 synthase / Q16873* / Q60860*ENSDARG0000006259826
mgst2 / microsomal glutathione S-transferase 2 / Q99735*ENSDARG0000007134522


Protein motifs (from Interpro)
Interpro ID Name
 IPR001129  Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein
 IPR001446  5-lipoxygenase-activating protein
 IPR023352  Membrane associated eicosanoid/glutathione metabolism-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0006691 leukotriene metabolic process IEA
 biological_processGO:0019370 leukotriene biosynthetic process IBA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 cellular_componentGO:0005635 nuclear envelope IBA
 cellular_componentGO:0005783 endoplasmic reticulum IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0008047 enzyme activator activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of 5-eicosatetraenoic acids
Synthesis of Leukotrienes (LT) and Eoxins (EX)
Synthesis of Lipoxins (LX)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000084 yolk yolk edematous , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel decreased functionality , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000054755 alox5ap / arachidonate 5-lipoxygenase-activating protein / P20292* / P30355*  / complex
 ENSDARG00000062598 ltc4s / leukotriene C4 synthase / Q16873* / Q60860*  / complex






 

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