ENSGALG00000026781


Gallus gallus

Features
Gene ID: ENSGALG00000026781
  
Biological name :ALOX5AP
  
Synonyms : ALOX5AP / arachidonate 5-lipoxygenase activating protein
  
Possible biological names infered from orthology : P20292 / P30355
  
Species: Gallus gallus
  
Chr. number: 1
Strand: -1
Band:
Gene start: 175088272
Gene end: 175096275
  
Corresponding Affymetrix probe sets: Gga.1758.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000051869
Ensembl peptide - ENSGALP00000041581
NCBI entrez gene - 770904     See in Manteia.
RefSeq - XM_015278225
RefSeq - NM_001278144
RefSeq Peptide - NP_001265073
swissprot - R4GHN1
swissprot - A0A1D5PGE7
Ensembl - ENSGALG00000026781
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 alox5apENSDARG00000054755Danio rerio
 P20292ENSG00000132965Homo sapiens
 P30355ENSMUSG00000060063Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LTC4S / leukotriene C4 synthase / Q16873* / Q60860*ENSGALG0000002127524
ENSGALG0000001145023
MGST2 / microsomal glutathione S-transferase 2 / Q99735*ENSGALG0000000980320


Protein motifs (from Interpro)
Interpro ID Name
 IPR001129  Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein
 IPR001446  5-lipoxygenase-activating protein
 IPR018295  FLAP/GST2/LTC4S, conserved site
 IPR023352  Membrane associated eicosanoid/glutathione metabolism-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002540 leukotriene production involved in inflammatory response IEA
 biological_processGO:0006691 leukotriene metabolic process IEA
 biological_processGO:0019370 leukotriene biosynthetic process IEA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope IBA
 cellular_componentGO:0005783 endoplasmic reticulum IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0008047 enzyme activator activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of 5-eicosatetraenoic acids
Synthesis of Leukotrienes (LT) and Eoxins (EX)
Synthesis of Lipoxins (LX)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000005857 ALOX5* / P09917* / P48999* / arachidonate 5-lipoxygenase*  / complex
 ENSGALG00000026781 ALOX5AP / arachidonate 5-lipoxygenase activating protein / P20292* / P30355*  / complex






 

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