ENSDARG00000057853


Danio rerio

Features
Gene ID: ENSDARG00000057853
  
Biological name :atp6v0ca
  
Synonyms : atp6v0ca / ATPase H+ transporting V0 subunit ca
  
Possible biological names infered from orthology : ATP6V0C / ATPase, H+ transporting, lysosomal V0 subunit C / ATPase H+ transporting V0 subunit c / P27449 / P63082
  
Species: Danio rerio
  
Chr. number: 3
Strand: -1
Band:
Gene start: 16044680
Gene end: 16055463
  
Corresponding Affymetrix probe sets: Dr.15693.1.S1_at (Zebrafish Array)   Dr.1971.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000014897
Ensembl peptide - ENSDARP00000110086
NCBI entrez gene - 192336     See in Manteia.
RefSeq - NM_001105136
RefSeq Peptide - NP_001098606
RefSeq Peptide - NP_775362
swissprot - F1QSP4
ZFIN ID - ZDB-GENE-020419-23
Ensembl - ENSDARG00000057853
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ATP6V0CENSGALG00000009229Gallus gallus
 P27449ENSG00000185883Homo sapiens
 P63082ENSMUSG00000024121Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
atp6v0cb / ATPase H+ transporting V0 subunit cb / P63082* / P27449* / ATP6V0C* / ATPase H+ transporting V0 subunit c* / ATPase, H+ transporting, lysosomal V0 subunit C*ENSDARG0000003657794


Protein motifs (from Interpro)
Interpro ID Name
 IPR000245  V-ATPase proteolipid subunit
 IPR002379  V-ATPase proteolipid subunit C-like domain
 IPR011555  V-ATPase proteolipid subunit C, eukaryotic


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001878 response to yeast IDA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0007042 lysosomal lumen acidification IBA
 biological_processGO:0015991 ATP hydrolysis coupled proton transport IEA
 biological_processGO:0060036 notochord cell vacuolation IMP
 biological_processGO:0060041 retina development in camera-type eye IMP
 biological_processGO:0060059 embryonic retina morphogenesis in camera-type eye IMP
 cellular_componentGO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain IBA
 cellular_componentGO:0005773 vacuole IEA
 cellular_componentGO:0005774 vacuolar membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IBA
 cellular_componentGO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain IEA
 cellular_componentGO:0033179 proton-transporting V-type ATPase, V0 domain IEA
 molecular_functionGO:0015078 proton transmembrane transporter activity IEA
 molecular_functionGO:0046961 proton-transporting ATPase activity, rotational mechanism IBA


Pathways (from Reactome)
Pathway description
ROS, RNS production in phagocytes
Neutrophil degranulation
Insulin receptor recycling
Transferrin endocytosis and recycling
Ion channel transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain necrotic , abnormal
Show

 ZFA:0000012 central nervous system central nervous system necrotic , abnormal
Show

 ZFA:0000107 eye eye color , abnormal
eye decreased size , abnormal
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 ZFA:0000108 fin fin malformed , abnormal
Show

 ZFA:0000112 gut gut hypoplastic , abnormal
gut decreased size , abnormal
Show

 ZFA:0000123 liver liver hypoplastic , abnormal
liver decreased size , abnormal
Show

 ZFA:0000135 notochord notochord vacuole broken , abnormal
Show

 ZFA:0000144 retinal pigmented epithelium retinal pigmented epithelium quality , abnormal
retinal pigmented epithelium morphology , abnormal
retinal pigmented epithelium malformed , abnormal
retinal pigmented epithelium physical object quality , abnormal
retinal pigmented epithelium translucent , abnormal
Show

 ZFA:0000292 surface structure surface structure quality , abnormal
Show

 ZFA:0000396 nervous system nervous system quality , abnormal
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 ZFA:0001094 whole organism whole organism low saturation , abnormal
whole organism viability , abnormal
whole organism bent , abnormal
whole organism decreased pigmentation , abnormal
whole organism unpigmented , abnormal
whole organism lethal (sensu genetics) , abnormal
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 ZFA:0001114 head head decreased size , abnormal
head decreased pigmentation , abnormal
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 ZFA:0001161 pectoral fin pectoral fin quality , abnormal
pectoral fin ruffled , abnormal
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 ZFA:0005220 larval melanophore stripe larval melanophore stripe melanocyte translucent , abnormal
Show

 ZFA:0009090 pigment cell pigment cell quality , abnormal
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 ZFA:0009091 melanocyte melanocyte quality , abnormal
melanocyte decreased amount , abnormal
melanocyte punctate , abnormal
melanocyte increased size , abnormal
melanocyte malformed , abnormal
melanocyte translucent , abnormal
melanocyte absent , abnormal
Show

 ZFA:0009154 eye photoreceptor cell eye photoreceptor cell photoreceptor outer segment decreased size , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000057853 atp6v0ca / ATPase H+ transporting V0 subunit ca / P63082* / P27449* / ATP6V0C* / ATPase H+ transporting V0 subunit c* / ATPase, H+ transporting, lysosomal V0 subunit C*  / complex
 ENSDARG00000036577 atp6v0cb / ATPase H+ transporting V0 subunit cb / P63082* / P27449* / ATP6V0C* / ATPase H+ transporting V0 subunit c* / ATPase, H+ transporting, lysosomal V0 subunit C*  / complex






 

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