ENSDARG00000070570


Danio rerio

Features
Gene ID: ENSDARG00000070570
  
Biological name :ppp4ca
  
Synonyms : A8WGP3 / ppp4ca / protein phosphatase 4, catalytic subunit a
  
Possible biological names infered from orthology : P60510 / P97470 / PPP4C / protein phosphatase 4 catalytic subunit
  
Species: Danio rerio
  
Chr. number: 3
Strand: -1
Band:
Gene start: 26236279
Gene end: 26244256
  
Corresponding Affymetrix probe sets: Dr.3992.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000094516
NCBI entrez gene - 100003080     See in Manteia.
swissprot - A8WGP3
swissprot - B7ZVT0
ZFIN ID - ZDB-GENE-030131-4433
Ensembl - ENSDARG00000070570
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PPP4CENSG00000149923Homo sapiens
 Ppp4cENSMUSG00000030697Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ppp4cb / A9JRC7 / protein phosphatase 4, catalytic subunit b / PPP4C* / P97470* / P60510* / protein phosphatase 4 catalytic subunit*ENSDARG0000007643995
ppp2cb / protein phosphatase 2, catalytic subunit, beta isozyme / P62715* / P62714* / protein phosphatase 2 catalytic subunit beta* / Serine/threonine-protein phosphatase 2A catalytic subun...ENSDARG0000009924164
ppp2ca / protein phosphatase 2, catalytic subunit, alpha isozymeENSDARG0000003022463
PPP2CA / zgc:56064 / P67775* / P63330* / protein phosphatase 2 catalytic subunit alpha* / Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform *ENSDARG0000005340463


Protein motifs (from Interpro)
Interpro ID Name
 IPR004843  Calcineurin-like phosphoesterase domain, ApaH type
 IPR006186  Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
 IPR029052  Metallo-dependent phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007420 brain development IMP
 biological_processGO:0009953 dorsal/ventral pattern formation IMP
 biological_processGO:0021952 central nervous system projection neuron axonogenesis IMP
 biological_processGO:0048264 determination of ventral identity IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Processing of DNA double-strand break ends


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain morphology , abnormal
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 ZFA:0000029 hindbrain hindbrain axon decreased length , abnormal
hindbrain axon disorganized , abnormal
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 ZFA:0000084 yolk yolk edematous , abnormal
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 ZFA:0000109 forebrain forebrain axon decreased size , abnormal
forebrain axon disorganized , abnormal
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 ZFA:0000128 midbrain midbrain shape , abnormal
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 ZFA:0000155 somite somite U-shaped , abnormal
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 ZFA:0001094 whole organism whole organism necrotic , abnormal
whole organism wholly dorsalized , abnormal
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 ZFA:0001117 post-vent region post-vent region shape , abnormal
post-vent region decreased length , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel decreased functionality , abnormal
intersegmental vessel dilated , abnormal
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 ZFA:0009090 pigment cell pigment cell decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000026540 ppp4r2a / protein phosphatase 4, regulatory subunit 2a / PPP4R2* / Q9NY27* / protein phosphatase 4 regulatory subunit 2*  / complex
 ENSDARG00000053447 A1L1M4 / ppp4r2b / protein phosphatase 4, regulatory subunit 2b / PPP4R2* / Q9NY27* / protein phosphatase 4 regulatory subunit 2*  / complex
 ENSDARG00000003938 rpa1 / Q6NY74 / replication protein A1 / Q8VEE4* / P27694* / Replication protein A 70 kDa DNA-binding subunit *  / reaction
 ENSDARG00000037188 rpa2 / replication protein A2 / RPA4* / Q13156* / P15927* / replication protein A4*  / reaction






 

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