ENSDARG00000071694


Danio rerio

Features
Gene ID: ENSDARG00000071694
  
Biological name :ndc80
  
Synonyms : ndc80 / NDC80 kinetochore complex component / Q6DRJ7
  
Possible biological names infered from orthology : Kinetochore / O14777 / Q9D0F1
  
Species: Danio rerio
  
Chr. number: 12
Strand: -1
Band:
Gene start: 10353333
Gene end: 10365969
  
Corresponding Affymetrix probe sets: Dr.25652.1.S1_at (Zebrafish Array)   NM_001003863_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000123651
Ensembl peptide - ENSDARP00000012236
NCBI entrez gene - 445386     See in Manteia.
RefSeq - NM_001003863
RefSeq Peptide - NP_001003863
swissprot - E9QBF3
swissprot - Q6DRJ7
ZFIN ID - ZDB-GENE-030131-904
Ensembl - ENSDARG00000071694
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NDC80ENSGALG00000014801Gallus gallus
 NDC80ENSG00000080986Homo sapiens
 Ndc80ENSMUSG00000024056Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR005550  Kinetochore protein Ndc80


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007052 mitotic spindle organization ISS
 biological_processGO:0007059 chromosome segregation ISS
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051310 metaphase plate congression ISS
 biological_processGO:0051315 attachment of mitotic spindle microtubules to kinetochore ISS
 biological_processGO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint ISS
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore ISS
 cellular_componentGO:0000777 condensed chromosome kinetochore ISS
 cellular_componentGO:0000778 condensed nuclear chromosome kinetochore IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0031262 Ndc80 complex IBA
 molecular_functionGO:0005200 structural constituent of cytoskeleton IBA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain necrotic , abnormal
Show

 ZFA:0000012 central nervous system central nervous system necrotic , abnormal
Show

 ZFA:0001094 whole organism whole organism viability , abnormal
whole organism necrotic , abnormal
Show

 ZFA:0001114 head head flat , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000024471 nsl1 / NSL1, MIS12 kinetochore complex component / Q96IY1*  / complex
 ENSDARG00000077822 si:dkey-6i22.5 / PMF1* / Q6P1K2* / Q9CPV5* / PMF1-BGLAP* / PMF1-BGLAP readthrough* / polyamine modulated factor 1*  / complex
 ENSDARG00000089922 dsn1 / DSN1 homolog, MIS12 kinetochore complex component / Q9H410*  / complex
 ENSDARG00000034624 nuf2 / Q7ZW63 / NUF2, NDC80 kinetochore complex component, homolog / Q99P69* / Q9BZD4* / NUF2, NDC80 kinetochore complex component* / Mus musculus NUF2, NDC80 kinetochore complex component ...  / complex
 ENSDARG00000093622 spc24 / Q503N2 / SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae) / Q9D083* / Q8NBT2* / Kinetochore protein Spc24 * / SPC24, NDC80 kinetochore complex component*  / complex
 ENSDARG00000078433 spc25 / SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) / Q9HBM1* / Q3UA16* / Kinetochore protein Spc25 * / SPC25, NDC80 kinetochore complex component*  / complex






 

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