ENSDARG00000074471


Danio rerio

Features
Gene ID: ENSDARG00000074471
  
Biological name :vps39
  
Synonyms : vacuolar protein sorting 39 homolog (S. cerevisiae) / vps39
  
Possible biological names infered from orthology : Q8R5L3 / Q96JC1 / VPS39, HOPS complex subunit
  
Species: Danio rerio
  
Chr. number: 17
Strand: 1
Band:
Gene start: 50074372
Gene end: 50114272
  
Corresponding Affymetrix probe sets: Dr.18700.1.S1_at (Zebrafish Array)   Dr.23838.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000100792
Ensembl peptide - ENSDARP00000129254
swissprot - F1RCV6
swissprot - X1WG99
ZFIN ID - ZDB-GENE-080530-2
Ensembl - ENSDARG00000074471
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 VPS39ENSGALG00000008991Gallus gallus
 VPS39ENSG00000166887Homo sapiens
 Vps39ENSMUSG00000027291Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tgfbrap1 / transforming growth factor, beta receptor associated protein 1 / Q3UR70* / Q8WUH2* / Mus musculus transforming growth factor, beta receptor associated protein 1 (Tgfbrap1), trans...ENSDARG0000006150824
si:ch211-266g18.9ENSDARG0000007590521


Protein motifs (from Interpro)
Interpro ID Name
 IPR000547  Clathrin, heavy chain/VPS, 7-fold repeat
 IPR001180  Citron homology (CNH) domain
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR019452  Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated domain 1
 IPR019453  Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated domain 2
 IPR032914  Vam6/VPS39/TRAP1 family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001654 eye development IMP
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IMP
 biological_processGO:0048066 developmental pigmentation IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005765 lysosomal membrane IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000046 retinal neural layer retinal neural layer apoptotic , abnormal
Show

 ZFA:0000076 swim bladder swim bladder agenesis , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000123 liver liver increased size , abnormal
liver discolored , abnormal
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 ZFA:0000144 retinal pigmented epithelium retinal pigmented epithelium melanocyte colorless , abnormal
retinal pigmented epithelium swollen , abnormal
retinal pigmented epithelium microvillus decreased amount , abnormal
retinal pigmented epithelium melanosome shape , abnormal
retinal pigmented epithelium melanosome immature , abnormal
retinal pigmented epithelium melanosome decreased amount , abnormal
retinal pigmented epithelium morphology , abnormal
retinal pigmented epithelium vesicle present , abnormal
retinal pigmented epithelium melanocyte colored , abnormal
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 ZFA:0000368 integument integument melanocyte colorless , abnormal
integument colored , abnormal
integument melanosome shape , abnormal
integument melanosome decreased amount , abnormal
integument melanocyte colored , abnormal
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 ZFA:0001094 whole organism whole organism anterior-posterior axis decreased length , abnormal
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 ZFA:0001114 head head phagocyte present , abnormal
head decreased size , abnormal
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 ZFA:0001117 post-vent region post-vent region phagocyte present , abnormal
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 ZFA:0001338 intestine intestine discolored , abnormal
intestine vesicle increased amount , abnormal
intestine vesicle decreased size , abnormal
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 ZFA:0001466 photoreceptor outer segment layer photoreceptor outer segment layer decreased length , abnormal
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 ZFA:0009111 hepatocyte hepatocyte vesicle present , abnormal
hepatocyte increased size , abnormal
hepatocyte necrotic , abnormal
hepatocyte disorganized , abnormal
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 ZFA:0009141 macrophage macrophage vesicle increased size , abnormal
macrophage vesicle variant shape , abnormal
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 ZFA:0009199 iridophore iridophore reflectivity , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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