ENSDARG00000075923


Danio rerio

Features
Gene ID: ENSDARG00000075923
  
Biological name :txnrd2.2
  
Synonyms : thioredoxin reductase 2, tandem duplicate 2 / txnrd2.2
  
Possible biological names infered from orthology : Q9NNW7 / thioredoxin reductase 2 / TXNRD2
  
Species: Danio rerio
  
Chr. number: 5
Strand: -1
Band:
Gene start: 15311591
Gene end: 15350252
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000103469
Ensembl peptide - ENSDARP00000117652
swissprot - E9QEM7
swissprot - F1Q6Z6
ZFIN ID - ZDB-GENE-040914-66
Ensembl - ENSDARG00000075923
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TXNRD2ENSGALG00000001988Gallus gallus
 Q9NNW7ENSG00000184470Homo sapiens
 Txnrd2ENSMUSG00000075704Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
txnrd3 / thioredoxin reductase 3 / Q86VQ6*ENSDARG0000010037454
txnrd2.1 / thioredoxin reductase 2, tandem duplicate 1 / Q9NNW7* / TXNRD2* / thioredoxin reductase 2*ENSDARG0000009447040
gsr / glutathione reductase / P47791* / P00390* / glutathione-disulfide reductase* / Glutathione reductase, mitochondrial *ENSDARG0000001923629


Protein motifs (from Interpro)
Interpro ID Name
 IPR004099  Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
 IPR006338  Thioredoxin/glutathione reductase selenoprotein
 IPR012999  Pyridine nucleotide-disulphide oxidoreductase, class I, active site
 IPR016156  FAD/NAD-linked reductase, dimerisation domain superfamily
 IPR023753  FAD/NAD(P)-binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000305 response to oxygen radical IBA
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0045454 cell redox homeostasis IBA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 cellular_componentGO:0005739 mitochondrion IBA
 molecular_functionGO:0004791 thioredoxin-disulfide reductase activity IEA
 molecular_functionGO:0009055 electron transfer activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding IEA


Pathways (from Reactome)
Pathway description
Detoxification of Reactive Oxygen Species


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000034777 txn2 / thioredoxin 2 / P97493* / Q99757*  / reaction
 ENSDARG00000075923 txnrd2.2 / thioredoxin reductase 2, tandem duplicate 2 / Q9NNW7* / TXNRD2* / thioredoxin reductase 2*  / complex






 

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